Co-activation of synaptic and extrasynaptic NMDA receptors by neuronal insults determines cell death in acute brain slice

Neurochemistry International

Volumn 78, Issue , 2014, Pages 28-34

  Chen, Zhuoyou ^a   Zhou, Quan ^b   Zhang, Min ^a   Wang, Hongbing ^c   Yun, Weiwen ^a   Zhou, Xianju ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE FIRST PEOPLE S HOSPITAL OF FOSHAN   (China)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Brain slice; Excitotoxicity; Extrasynaptic NMDA receptors; Glutamate; Synaptic NMDA receptors

Indexed keywords

BICUCULLINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIZOCILPINE; GLUTAMIC ACID; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL ACTIVATION; CELL HYPOXIA; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; MALE; NERVE CELL NECROSIS; NONHUMAN; RAT; SYNAPTIC TRANSMISSION; UPREGULATION; AGONISTS; ANIMAL; CELL DEATH; CYTOLOGY; DRUG EFFECTS; FRONTAL LOBE; METABOLISM; NERVE CELL; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNAPSE;

ANIMALS; BICUCULLINE; CELL DEATH; FRONTAL LOBE; MALE; NEURONS; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 84907887230     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.08.003     Document Type: Article

References (32)

1. S.M. Adams, J.C. de Rivero Vaccari, and R.A. Corriveau Pronounced cell death in the absence of NMDA receptors in the developing somatosensory thalamus J. Neurosci. 24 2004 9441 9450
2. E.E. Benarroch NMDA receptors: recent insights and clinical correlations Neurology 76 2011 1750 1757
3. L.K. Friedman, and M. Segal Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity Int. J. Dev. Neurosci. 28 2010 195 205
4. M.P. Goldberg, and D.W. Choi Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury J. Neurosci. 13 1993 3510 3524
5. G.E. Hardingham, F.J. Arnold, and H. Bading Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity Nat. Neurosci. 4 2001 261 267
6. G.E. Hardingham, Y. Fukunaga, and H. Bading Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways Nat. Neurosci. 5 2002 405 414
7. G.E. Hardingham, and H. Bading Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders Nat. Rev. Neurosci. 11 2010 682 696
8. A.Z. Harris, and D.L. Pettit Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices J. Physiol. 584 2007 509 519
9. A.Z. Harris, and D.L. Pettit Recruiting extrasynaptic NMDA receptors augments synaptic signaling J. Neurophysiol. 99 2008 524 533
10. C. Ikonomidou, F. Bosch, M. Miksa, P. Bittigau, J. Vockler, K. Dikranian, T.I. Tenkova, V. Stefovska, L. Turski, and J.W. Olney Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain Science 283 1999 70 74
11. A. Ivanov, C. Pellegrino, S. Rama, I. Dumalska, Y. Salyha, Y. Ben-Ari, and I. Medina Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons J. Physiol. 572 2006 789 798
12. T.W. Lai, S. Zhang, and Y.T. Wang Excitotoxicity and stroke: identifying novel targets for neuroprotection Prog. Neurobiol. 115 2014 157 188
13. B. Lee, G.Q. Butcher, K.R. Hoyt, S. Impey, and K. Obrietan Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133 J. Neurosci. 25 2005 1137 1148
14. S. Lesne, C. Ali, C. Gabriel, N. Croci, E.T. MacKenzie, C.G. Glabe, M. Plotkine, C. Marchand-Verrecchia, D. Vivien, and A. Buisson NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production J. Neurosci. 25 2005 9367 9377
15. F. Leveille, F. El Gaamouch, E. Gouix, M. Lecocq, D. Lobner, O. Nicole, and A. Buisson Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors FASEB J. 22 2008 4258 4271
16. A.J. Milnerwood, C.M. Gladding, M.A. Pouladi, A.M. Kaufman, R.M. Hines, J.D. Boyd, R.W. Ko, O.C. Vasuta, R.K. Graham, M.R. Hayden, T.H. Murphy, and L.A. Raymond Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice Neuron 65 2010 178 190
17. E. Mozes, A. Hunya, A. Posa, B. Penke, and Z. Datki A novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays Brain Res. Bull. 87 2012 521 525
18. H. Nie, and H.R. Weng Glutamate transporters prevent excessive activation of NMDA receptors and extrasynaptic glutamate spillover in the spinal dorsal horn J. Neurophysiol. 101 2009 2041 2051
19. T. Papouin, L. Ladepeche, J. Ruel, S. Sacchi, M. Labasque, M. Hanini, L. Groc, L. Pollegioni, J.P. Mothet, and S.H. Oliet Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists Cell 150 2012 633 646
20. I. Perez-Otano, R. Lujan, S.J. Tavalin, M. Plomann, J. Modregger, X.B. Liu, E.G. Jones, S.F. Heinemann, D.C. Lo, and M.D. Ehlers Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1 Nat. Neurosci. 9 2006 611 621
21. R.S. Petralia, Y.X. Wang, F. Hua, Z. Yi, A. Zhou, L. Ge, F.A. Stephenson, and R.J. Wenthold Organization of NMDA receptors at extrasynaptic locations Neuroscience 167 2010 68 87
22. R. Sattler, Z. Xiong, W.Y. Lu, J.F. MacDonald, and M. Tymianski Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity J. Neurosci. 20 2000 22 33
23. R.I. Stanika, N.B. Pivovarova, C.A. Brantner, C.A. Watts, C.A. Winters, and S.B. Andrews Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity Proc. Natl. Acad. Sci. U.S.A. 106 2009 9854 9859
24. C. Taghibiglou, H.G. Martin, T.W. Lai, T. Cho, S. Prasad, L. Kojic, J. Lu, Y. Liu, E. Lo, S. Zhang, J.Z. Wu, Y.P. Li, Y.H. Wen, J.H. Imm, M.S. Cynader, and Y.T. Wang Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries Nat. Med. 15 2009 1399 1406
25. C.G. Thomas, A.J. Miller, and G.L. Westbrook Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons J. Neurophysiol. 95 2006 1727 1734
26. E.M. Ullian, W.B. Barkis, S. Chen, J.S. Diamond, and B.A. Barres Invulnerability of retinal ganglion cells to NMDA excitotoxicity Mol. Cell. Neurosci. 26 2004 544 557
27. J. von Engelhardt, I. Coserea, V. Pawlak, E.C. Fuchs, G. Kohr, P.H. Seeburg, and H. Monyer Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors Neuropharmacology 53 2007 10 17
28. A.R. Wild, E. Akyol, S.L. Brothwell, P. Kimkool, J.N. Skepper, A.J. Gibb, and S. Jones Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones Neuropharmacology 73 2013 138 146
29. C.M. Wroge, J. Hogins, L. Eisenman, and S. Mennerick Synaptic NMDA receptors mediate hypoxic excitotoxic death J. Neurosci. 32 2012 6732 6742
30. L. Yurkewicz, J. Weaver, M.R. Bullock, and L.F. Marshall The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury J. Neurotrauma 22 2005 1428 1443
31. X. Zhou, Q. Ding, Z. Chen, H. Yun, and H. Wang Involvement of the GluN2A and GluN2B subunits in synaptic and extrasynaptic N-methyl-d-aspartate receptor function and neuronal excitotoxicity J. Biol. Chem. 288 2013 24151 24159
32. X. Zhou, D. Hollern, J. Liao, E. Andrechek, and H. Wang NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors Cell Death Dis. 4 2013 e560