메뉴 건너뛰기




Volumn 288, Issue 33, 2013, Pages 24151-24159

Involvement of the GluN2A and GluN2B subunits in synaptic and extrasynaptic N-methyl-D-aspartate receptor function and neuronal excitotoxicity

Author keywords

[No Author keywords available]

Indexed keywords

EXCITOTOXICITY; N METHYL D ASPARTATE RECEPTOR; NEURONAL SIGNALING;

EID: 84882296707     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.482000     Document Type: Article
Times cited : (117)

References (58)
  • 4
    • 14644427746 scopus 로고    scopus 로고
    • NMDAreceptor-dependent regulation of axonal and dendritic branching
    • Lee, L. J., Lo, F. S., and Erzurumlu, R. S. (2005)NMDAreceptor-dependent regulation of axonal and dendritic branching. J. Neurosci. 25, 2304-2311
    • (2005) J. Neurosci. , vol.25 , pp. 2304-2311
    • Lee, L.J.1    Lo, F.S.2    Erzurumlu, R.S.3
  • 6
    • 30844439634 scopus 로고    scopus 로고
    • Glutamate-based therapeutic approaches. Clinical trials with NMDA antagonists
    • Muir, K. W. (2006) Glutamate-based therapeutic approaches. Clinical trials with NMDA antagonists. Curr. Opin. Pharmacol. 6, 53-60
    • (2006) Curr. Opin. Pharmacol. , vol.6 , pp. 53-60
    • Muir, K.W.1
  • 7
    • 55749108180 scopus 로고    scopus 로고
    • Differential roles ofNMDAreceptor subtypes in ischemic neuronal cell death and ischemic tolerance
    • Chen, M., Lu, T. J., Chen, X. J., Zhou, Y., Chen, Q., Feng, X. Y., Xu, L., Duan, W. H., and Xiong, Z. Q. (2008) Differential roles ofNMDAreceptor subtypes in ischemic neuronal cell death and ischemic tolerance. Stroke 39, 3042-3048
    • (2008) Stroke , vol.39 , pp. 3042-3048
    • Chen, M.1    Lu, T.J.2    Chen, X.J.3    Zhou, Y.4    Chen, Q.5    Feng, X.Y.6    Xu, L.7    Duan, W.H.8    Xiong, Z.Q.9
  • 9
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic versus extrasynaptic NMDAreceptor signaling. Implications for neurodegenerative disorders
    • Hardingham, G. E., and Bading, H. (2010) Synaptic versus extrasynaptic NMDAreceptor signalling. Implications for neurodegenerative disorders. Nat. Rev. Neurosci. 11, 682-696
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 11
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., and Seeburg, P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540
    • (1994) Neuron , vol.12 , pp. 529-540
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakmann, B.4    Seeburg, P.H.5
  • 12
    • 35348900781 scopus 로고    scopus 로고
    • Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices
    • Harris, A. Z., and Pettit, D. L. (2007) Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices. J. Physiol. 584, 509-519
    • (2007) J. Physiol. , vol.584 , pp. 509-519
    • Harris, A.Z.1    Pettit, D.L.2
  • 13
    • 33645822456 scopus 로고    scopus 로고
    • Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons
    • Thomas, C. G., Miller, A. J., and Westbrook, G. L. (2006) Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons. J. Neurophysiol. 95, 1727-1734
    • (2006) J. Neurophysiol. , vol.95 , pp. 1727-1734
    • Thomas, C.G.1    Miller, A.J.2    Westbrook, G.L.3
  • 14
    • 54049087697 scopus 로고    scopus 로고
    • Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
    • Yashiro, K., and Philpot, B. D. (2008) Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity. Neuropharmacology 55, 1081-1094
    • (2008) Neuropharmacology , vol.55 , pp. 1081-1094
    • Yashiro, K.1    Philpot, B.D.2
  • 17
    • 84875889310 scopus 로고    scopus 로고
    • NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors
    • Zhou, X., Hollern, D., Liao, J., Andrechek, E., and Wang, H. (2013)NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors. Cell Death Dis. 4, e560
    • (2013) Cell Death Dis. , vol.4
    • Zhou, X.1    Hollern, D.2    Liao, J.3    Andrechek, E.4    Wang, H.5
  • 18
    • 83055173316 scopus 로고    scopus 로고
    • Regulation of brain-derived neurotrophic factor exon IV transcription through calcium responsive elements in cortical neurons
    • Zheng, F., Zhou, X., Luo, Y., Xiao, H., Wayman, G., and Wang, H. (2011) Regulation of brain-derived neurotrophic factor exon IV transcription through calcium responsive elements in cortical neurons. PLoS ONE 6, e28441
    • (2011) PLoS ONE , vol.6
    • Zheng, F.1    Zhou, X.2    Luo, Y.3    Xiao, H.4    Wayman, G.5    Wang, H.6
  • 19
    • 33947524937 scopus 로고    scopus 로고
    • Simultaneous labeling of projecting neurons and apoptotic state
    • Nguyen, S. M., Lieven, C. J., and Levin, L. A. (2007) Simultaneous labeling of projecting neurons and apoptotic state. J. Neurosci. Methods 161, 281-284
    • (2007) J. Neurosci. Methods , vol.161 , pp. 281-284
    • Nguyen, S.M.1    Lieven, C.J.2    Levin, L.A.3
  • 20
    • 67649400331 scopus 로고    scopus 로고
    • Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction
    • Chen, K., Zhang, Q., Wang, J., Liu, F., Mi, M., Xu, H., Chen, F., and Zeng, K. (2009) Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction. Brain Res. 1279, 131-138
    • (2009) Brain Res. , vol.1279 , pp. 131-138
    • Chen, K.1    Zhang, Q.2    Wang, J.3    Liu, F.4    Mi, M.5    Xu, H.6    Chen, F.7    Zeng, K.8
  • 21
    • 0027328680 scopus 로고
    • Combined oxygen and glucose deprivation in cortical cell culture. Calcium-dependent and calcium-independent mechanisms of neuronal injury
    • Goldberg, M. P., and Choi, D. W. (1993) Combined oxygen and glucose deprivation in cortical cell culture. Calcium-dependent and calcium-independent mechanisms of neuronal injury. J. Neurosci. 13, 3510-3524
    • (1993) J. Neurosci. , vol.13 , pp. 3510-3524
    • Goldberg, M.P.1    Choi, D.W.2
  • 22
    • 0035313299 scopus 로고    scopus 로고
    • Dendritic spines lost during glutamate receptor activation reemerge at original sites of synaptic contact
    • Hasbani, M. J., Schlief, M. L., Fisher, D. A., and Goldberg, M. P. (2001) Dendritic spines lost during glutamate receptor activation reemerge at original sites of synaptic contact. J. Neurosci. 21, 2393-2403
    • (2001) J. Neurosci. , vol.21 , pp. 2393-2403
    • Hasbani, M.J.1    Schlief, M.L.2    Fisher, D.A.3    Goldberg, M.P.4
  • 23
    • 84863308987 scopus 로고    scopus 로고
    • Bi-directional regulation of CaMKIIα phosphorylation at Thr-286 by NMDA receptors in cultured cortical neurons
    • Zhou, X., Zheng, F., Moon, C., Schluter, O. M., and Wang, H. (2012) Bi-directional regulation of CaMKIIα phosphorylation at Thr-286 by NMDA receptors in cultured cortical neurons. J. Neurochem. 122, 295-307
    • (2012) J. Neurochem. , vol.122 , pp. 295-307
    • Zhou, X.1    Zheng, F.2    Moon, C.3    Schluter, O.M.4    Wang, H.5
  • 24
    • 77956998216 scopus 로고    scopus 로고
    • Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors
    • Sanz-Clemente, A., Matta, J. A., Isaac, J. T., and Roche, K. W. (2010) Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. Neuron 67, 984-996
    • (2010) Neuron , vol.67 , pp. 984-996
    • Sanz-Clemente, A.1    Matta, J.A.2    Isaac, J.T.3    Roche, K.W.4
  • 26
    • 84858847955 scopus 로고    scopus 로고
    • Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation
    • Navon, H., Bromberg, Y., Sperling, O., and Shani, E. (2012) Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation. J. Mol. Neurosci. 46, 100-108
    • (2012) J. Mol. Neurosci. , vol.46 , pp. 100-108
    • Navon, H.1    Bromberg, Y.2    Sperling, O.3    Shani, E.4
  • 27
    • 0035575852 scopus 로고    scopus 로고
    • Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo
    • Mabuchi, T., Kitagawa, K., Kuwabara, K., Takasawa, K., Ohtsuki, T., Xia, Z., Storm, D., Yanagihara, T., Hori, M., and Matsumoto, M. (2001) Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo. J. Neurosci. 21, 9204-9213
    • (2001) J. Neurosci. , vol.21 , pp. 9204-9213
    • Mabuchi, T.1    Kitagawa, K.2    Kuwabara, K.3    Takasawa, K.4    Ohtsuki, T.5    Xia, Z.6    Storm, D.7    Yanagihara, T.8    Hori, M.9    Matsumoto, M.10
  • 28
    • 24944557047 scopus 로고    scopus 로고
    • Activation of NR2A-containingNMDAreceptors is not obligatory for NMDA receptor-dependent long-term potentiation
    • Weitlauf, C., Honse, Y., Auberson, Y. P., Mishina, M., Lovinger, D. M., and Winder, D. G. (2005) Activation of NR2A-containingNMDAreceptors is not obligatory for NMDA receptor-dependent long-term potentiation. J. Neurosci. 25, 8386-8390
    • (2005) J. Neurosci. , vol.25 , pp. 8386-8390
    • Weitlauf, C.1    Honse, Y.2    Auberson, Y.P.3    Mishina, M.4    Lovinger, D.M.5    Winder, D.G.6
  • 30
    • 0028219211 scopus 로고
    • Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
    • Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., and Jan, L. Y. (1994) Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368, 144-147
    • (1994) Nature , vol.368 , pp. 144-147
    • Sheng, M.1    Cummings, J.2    Roldan, L.A.3    Jan, Y.N.4    Jan, L.Y.5
  • 31
    • 0031844719 scopus 로고    scopus 로고
    • Developmental changes in localization of NMDA receptor subunits in primary cultures of cortical neurons
    • Li, J. H., Wang, Y. H., Wolfe, B. B., Krueger, K. E., Corsi, L., Stocca, G., and Vicini, S. (1998) Developmental changes in localization of NMDA receptor subunits in primary cultures of cortical neurons. Eur. J. Neurosci. 10, 1704-1715
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 1704-1715
    • Li, J.H.1    Wang, Y.H.2    Wolfe, B.B.3    Krueger, K.E.4    Corsi, L.5    Stocca, G.6    Vicini, S.7
  • 32
    • 82955232374 scopus 로고    scopus 로고
    • Developmental changes of TrkB signaling in response to exogenous brain-derived neurotrophic factor in primary cortical neurons
    • Zhou, X., Xiao, H., and Wang, H. (2011) Developmental changes of TrkB signaling in response to exogenous brain-derived neurotrophic factor in primary cortical neurons. J. Neurochem. 119, 1205-1216
    • (2011) J. Neurochem. , vol.119 , pp. 1205-1216
    • Zhou, X.1    Xiao, H.2    Wang, H.3
  • 33
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi, D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 34
    • 35948947269 scopus 로고    scopus 로고
    • On the hypes and falls in neuroprotection. Targeting the NMDA receptor
    • Villmann, C., and Becker, C. M. (2007) On the hypes and falls in neuroprotection. Targeting the NMDA receptor. Neuroscientist 13, 594-615
    • (2007) Neuroscientist , vol.13 , pp. 594-615
    • Villmann, C.1    Becker, C.M.2
  • 36
    • 84860669170 scopus 로고    scopus 로고
    • Comparative impact of voltage-gated calcium channels and NMDAreceptors on mitochondria-mediated neuronal injury
    • Stanika, R. I., Villanueva, I., Kazanina, G., Andrews, S. B., and Pivovarova, N. B. (2012) Comparative impact of voltage-gated calcium channels and NMDAreceptors on mitochondria-mediated neuronal injury. J. Neurosci. 32, 6642-6650
    • (2012) J. Neurosci. , vol.32 , pp. 6642-6650
    • Stanika, R.I.1    Villanueva, I.2    Kazanina, G.3    Andrews, S.B.4    Pivovarova, N.B.5
  • 38
    • 0035693680 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death
    • Sattler, R., and Tymianski, M. (2001) Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol. Neurobiol. 24, 107-129
    • (2001) Mol. Neurobiol. , vol.24 , pp. 107-129
    • Sattler, R.1    Tymianski, M.2
  • 39
    • 0024344822 scopus 로고
    • Direct evidence that excitotoxicity in cultured neurons is mediated via N-methyl-D-aspartate (NMDA) as well as non-NMDA receptors
    • Frandsen, A., Drejer, J., and Schousboe, A. (1989) Direct evidence that excitotoxicity in cultured neurons is mediated via N-methyl-D-aspartate (NMDA) as well as non-NMDA receptors. J. Neurochem. 53, 297-299
    • (1989) J. Neurochem. , vol.53 , pp. 297-299
    • Frandsen, A.1    Drejer, J.2    Schousboe, A.3
  • 40
    • 0028178139 scopus 로고
    • 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells
    • 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells. J. Neurosci. 14, 187-197
    • (1994) J. Neurosci. , vol.14 , pp. 187-197
    • Brorson, J.R.1    Manzolillo, P.A.2    Miller, R.J.3
  • 41
    • 77549083577 scopus 로고    scopus 로고
    • Calcium, ischemia and excitotoxicity
    • Szydlowska, K., and Tymianski, M. (2010) Calcium, ischemia and excitotoxicity. Cell Calcium 47, 122-129
    • (2010) Cell Calcium , vol.47 , pp. 122-129
    • Szydlowska, K.1    Tymianski, M.2
  • 44
    • 33745511425 scopus 로고    scopus 로고
    • Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function
    • Schlüter, O. M., Xu, W., and Malenka, R. C. (2006) Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function. Neuron 51, 99-111
    • (2006) Neuron , vol.51 , pp. 99-111
    • Schlüter, O.M.1    Xu, W.2    Malenka, R.C.3
  • 45
    • 43749116868 scopus 로고    scopus 로고
    • Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS
    • Miwa, H., Fukaya, M., Watabe, A. M., Watanabe, M., and Manabe, T. (2008) Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS. J. Physiol. 586, 2539-2550
    • (2008) J. Physiol. , vol.586 , pp. 2539-2550
    • Miwa, H.1    Fukaya, M.2    Watabe, A.M.3    Watanabe, M.4    Manabe, T.5
  • 46
    • 0033562610 scopus 로고    scopus 로고
    • The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
    • Tovar, K. R., and Westbrook, G. L. (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J. Neurosci. 19, 4180-4188
    • (1999) J. Neurosci. , vol.19 , pp. 4180-4188
    • Tovar, K.R.1    Westbrook, G.L.2
  • 49
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • Hardingham, G. E., Fukunaga, Y., and Bading, H. (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5, 405-414
    • (2002) Nat. Neurosci. , vol.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 51
    • 84860689529 scopus 로고    scopus 로고
    • Synaptic NMDA receptors mediate hypoxic excitotoxic death
    • Wroge, C. M., Hogins, J., Eisenman, L., and Mennerick, S. (2012) Synaptic NMDA receptors mediate hypoxic excitotoxic death. J. Neurosci. 32, 6732-6742
    • (2012) J. Neurosci. , vol.32 , pp. 6732-6742
    • Wroge, C.M.1    Hogins, J.2    Eisenman, L.3    Mennerick, S.4
  • 53
    • 77649183486 scopus 로고    scopus 로고
    • Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity
    • Friedman, L. K., and Segal, M. (2010) Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity. Int. J. Dev. Neurosci. 28, 195-205
    • (2010) Int. J. Dev. Neurosci. , vol.28 , pp. 195-205
    • Friedman, L.K.1    Segal, M.2
  • 54
    • 0036728049 scopus 로고    scopus 로고
    • Differential regulation of synaptic and extra-synaptic NMDA receptors
    • Li, B., Chen, N., Luo, T., Otsu, Y., Murphy, T. H., and Raymond, L. A. (2002) Differential regulation of synaptic and extra-synaptic NMDA receptors. Nat. Neurosci. 5, 833-834
    • (2002) Nat. Neurosci. , vol.5 , pp. 833-834
    • Li, B.1    Chen, N.2    Luo, T.3    Otsu, Y.4    Murphy, T.H.5    Raymond, L.A.6
  • 55
    • 70449487175 scopus 로고    scopus 로고
    • N-methyl-D-aspartate-stimulated ERK1/2 signaling and the transcriptional up-regulation of plasticity-related genes are developmentally regulated following in vitro neuronal maturation
    • Zhou, X., Moon, C., Zheng, F., Luo, Y., Soellner, D., Nuñez, J. L., and Wang, H. (2009) N-methyl-D-aspartate-stimulated ERK1/2 signaling and the transcriptional up-regulation of plasticity-related genes are developmentally regulated following in vitro neuronal maturation. J. Neurosci. Res. 87, 2632-2644
    • (2009) J. Neurosci. Res. , vol.87 , pp. 2632-2644
    • Zhou, X.1    Moon, C.2    Zheng, F.3    Luo, Y.4    Soellner, D.5    Nuñez, J.L.6    Wang, H.7
  • 57
    • 0036830627 scopus 로고    scopus 로고
    • NMDA receptor pathways as drug targets
    • Kemp, J. A., and McKernan, R. M. (2002) NMDA receptor pathways as drug targets. Nat. Neurosci. 5, 1039-1042
    • (2002) Nat. Neurosci. , vol.5 , pp. 1039-1042
    • Kemp, J.A.1    McKernan, R.M.2
  • 58
    • 0032400783 scopus 로고    scopus 로고
    • Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor
    • Morikawa, E., Mori, H., Kiyama, Y., Mishina, M., Asano, T., and Kirino, T. (1998) Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor. J. Neurosci. 18, 9727-9732
    • (1998) J. Neurosci. , vol.18 , pp. 9727-9732
    • Morikawa, E.1    Mori, H.2    Kiyama, Y.3    Mishina, M.4    Asano, T.5    Kirino, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.