메뉴 건너뛰기




Volumn 73, Issue , 2013, Pages 138-146

Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones

Author keywords

Excitotoxicity; Use dependent antagonist

Indexed keywords

DIZOCILPINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TYROSINE 3 MONOOXYGENASE;

EID: 84885165170     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.05.013     Document Type: Article
Times cited : (24)

References (65)
  • 1
    • 0028793257 scopus 로고
    • Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
    • Ankarcrona, M., Dypbukt, J.M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S.A., Nicotera, P., 1995. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15 (4), 961-973.
    • (1995) Neuron , vol.15 , Issue.4 , pp. 961-973
    • Ankarcrona, M.1    Dypbukt, J.M.2    Bonfoco, E.3    Zhivotovsky, B.4    Orrenius, S.5    Lipton, S.A.6    Nicotera, P.7
  • 2
    • 0026564612 scopus 로고
    • Glutamate stimulation of tyrosine hydroxylase is mediated by NMDA receptors in the rat striatum
    • Arias-Montaño, J.A., Martínez-Fong, D., Aceves, J., 1992. Glutamate stimulation of tyrosine hydroxylase is mediated by NMDA receptors in the rat striatum. Brain Res. 569, 317-322.
    • (1992) Brain Res. , vol.569 , pp. 317-322
    • Arias-Montaño, J.A.1    Martínez-Fong, D.2    Aceves, J.3
  • 3
    • 0034287012 scopus 로고    scopus 로고
    • Functional changes of the basal ganglia circuitry in Parkinson's disease
    • DOI 10.1016/S0301-0082(99)00067-2, PII S0301008299000672
    • Blandini, F., Nappi, G., Tassorelli, C, Martignoni, E., 2000. Functional changes of the basal ganglia circuitry in Parkinson's disease. Prog. Neurobiol. 62 (1), 63-88. (Pubitemid 30252017)
    • (2000) Progress in Neurobiology , vol.62 , Issue.1 , pp. 63-88
    • Blandini, F.1    Nappi, G.2    Tassorelli, C.3    Martignoni, E.4
  • 4
    • 0031020529 scopus 로고    scopus 로고
    • Trapping channel block of NMDA-activated responses by amantadine and memantine
    • Blanpied, T.A., Boeckman, F.A., Aizenman, E., Johnson, J.W., 1997. Trapping channel block of NMDA-activated responses by amantadine and memantine. J. Neurophysiol. 77, 309-323. (Pubitemid 27053786)
    • (1997) Journal of Neurophysiology , vol.77 , Issue.1 , pp. 309-323
    • Blanpied, T.A.1    Boeckman, F.A.2    Aizenman, E.3    Johnson, J.W.4
  • 5
    • 4143079145 scopus 로고    scopus 로고
    • Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells
    • DOI 10.1111/j.1471-4159.2004.02550.x
    • Bobrovskaya, L, Dunkley, P.R., Dickson, P.W., 2004. Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells. J. Neurochem. 90, 857-864. (Pubitemid 39099967)
    • (2004) Journal of Neurochemistry , vol.90 , Issue.4 , pp. 857-864
    • Bobrovskaya, L.1    Dunkley, P.R.2    Dickson, P.W.3
  • 7
    • 38849204753 scopus 로고    scopus 로고
    • NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones
    • DOI 10.1113/jphysiol.2007.144618
    • Brothwell, S.LC, Barber, J.L., Monaghan, D.T., Jane, D.E., Gibb, A.J., Jones, S., 2008. NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J. Physiol. 586, 739-750. (Pubitemid 351194114)
    • (2008) Journal of Physiology , vol.586 , Issue.3 , pp. 739-750
    • Brothwell, S.L.C.1    Barber, J.L.2    Monaghan, D.T.3    Jane, D.E.4    Gibb, A.J.5    Jones, S.6
  • 8
    • 0034024373 scopus 로고    scopus 로고
    • Differential vulnerabilities of substantia nigra catecholamine neurons to excitatory amino acid-induced degeneration in rat midbrain slices
    • DOI 10.1006/exnr.2000.7310
    • Bywood, P.T., Johnson, S.M., 2000. Differential vulnerabilities of substantia nigra catecholamine neurons to excitatory amino acid-induced degeneration in rat midbrain slices. Exp. Neurol. 162, 180-188. (Pubitemid 30170110)
    • (2000) Experimental Neurology , vol.162 , Issue.1 , pp. 180-188
    • Bywood, P.T.1    Johnson, S.M.2
  • 9
    • 33745034018 scopus 로고    scopus 로고
    • The chemical biology of clinically tolerated NMDA receptor antagonists
    • DOI 10.1111/j.1471-4159.2006.03991.x
    • Chen, H.S., Lipton, S.A., 2006. The chemical biology of clinically tolerated NMDA receptor antagonists. J. Neurochem. 97, 1611-1626. (Pubitemid 43873656)
    • (2006) Journal of Neurochemistry , vol.97 , Issue.6 , pp. 1611-1626
    • Chen, H.-S.V.1    Lipton, S.A.2
  • 10
    • 0031034905 scopus 로고    scopus 로고
    • Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: Uncompetitive antagonism
    • Chen, H.S., Lipton, S.A., 1997. Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J. Physiol. 499 (Pt 1), 27-46. (Pubitemid 27098863)
    • (1997) Journal of Physiology , vol.499 , Issue.1 , pp. 27-46
    • Chen, H.-S.V.1    Lipton, S.A.2
  • 11
    • 0032543788 scopus 로고    scopus 로고
    • Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation
    • DOI 10.1016/S0306-4522(98)00163-8, PII S0306452298001638
    • Chen, H.S., Wang, Y.F., Rayudu, P.V., Edgecomb, P., Neill, J.C., Segal, M.M., Lipton, S.A., Jensen, F.E., 1998. Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86, 1121-1132. (Pubitemid 28318538)
    • (1998) Neuroscience , vol.86 , Issue.4 , pp. 1121-1132
    • Chen, H.-S.V.1    Wang, Y.F.2    Rayudu, P.V.3    Edgecomb, P.4    Neill, J.C.5    Segal, M.M.6    Lipton, S.A.7    Jensen, F.E.8
  • 12
    • 0025921915 scopus 로고
    • Presynaptic adenosine A2 and N-methyl-D-aspartate receptors regulate dopamine synthesis in rat striatal synaptosomes
    • Chowdhury, M., Fillenz, M., 1991. Presynaptic adenosine A2 and N-methyl-D-aspartate receptors regulate dopamine synthesis in rat striatal synaptosomes. J. Neurochem. 56, 1783-1788.
    • (1991) J. Neurochem. , vol.56 , pp. 1783-1788
    • Chowdhury, M.1    Fillenz, M.2
  • 13
    • 16544376850 scopus 로고    scopus 로고
    • Role of distinct NMDA receptor subtypes at Central synapses
    • Cull-Candy, S.G., Leszkiewicz, D.N., 2004. Role of distinct NMDA receptor subtypes at central synapses. Sci. STKE 255, re16.
    • (2004) Sci. STKE , vol.255
    • Cull-Candy, S.G.1    Leszkiewicz, D.N.2
  • 14
    • 0030990693 scopus 로고    scopus 로고
    • Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents - Preclinical studies
    • DOI 10.1016/S0149-7634(96)00037-1, PII S0149763496000371
    • Danysz, W., Parsons, C.G., Kornhuber, J., Schmidt, W.J., Quack, G., 1997. Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents-preclinical studies. Neurosci. Biobehav. Rev. 21, 455-468. (Pubitemid 27255850)
    • (1997) Neuroscience and Biobehavioral Reviews , vol.21 , Issue.4 , pp. 455-468
    • Danysz, W.1    Parsons, C.G.2    Kornhuber, J.3    Schmidt, W.J.4    Quack, G.5
  • 15
    • 0033806044 scopus 로고    scopus 로고
    • NMDA channel blockers: Memantine and amino-aklylcyclohexanes - In vivo characterization
    • Danysz, W., Parsons, C.G., Quack, G., 2000. NMDA channel blockers: memantine and amino-aklylcyclohexanes - in vivo characterization. Amino Acids 19, 167-172.
    • (2000) Amino Acids , vol.19 , pp. 167-172
    • Danysz, W.1    Parsons, C.G.2    Quack, G.3
  • 16
    • 0028351227 scopus 로고
    • Opposite presynaptic regulations by glutamate through NMDA receptors of dopamine synthesis and release in rat striatal synaptosomes
    • Desce, J.M., Godeheu, G., Galli, T., Glowinski, J., Cheramy, A., 1994. Opposite pre-synaptic regulations by glutamate through NMDA receptors of dopamine synthesis and release in rat striatal synaptosomes. Brain Res. 640, 205-214. (Pubitemid 24086548)
    • (1994) Brain Research , vol.640 , Issue.1-2 , pp. 205-214
    • Desce, J.-M.1    Godeheu, G.2    Galli, T.3    Glowinski, J.4    Cheramy, A.5
  • 17
    • 0032967382 scopus 로고    scopus 로고
    • The role of excitotoxicity in neurodegenerative disease: Implications for therapy
    • DOI 10.1016/S0163-7258(98)00042-4, PII S0163725898000424
    • Doble, A., 1999. The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol. Ther. 81, 163-221. (Pubitemid 29094735)
    • (1999) Pharmacology and Therapeutics , vol.81 , Issue.3 , pp. 163-221
    • Doble, A.1
  • 18
    • 0000735715 scopus 로고
    • Substantia nigra
    • In: Paxinos, G. (Ed.) second ed. Academic Press
    • Fallon, J.H., Loughlin, S.E., 1995. Substantia nigra. In: Paxinos, G. (Ed.), The Rat Nervous System, second ed. Academic Press.
    • (1995) The Rat Nervous System
    • Fallon, J.H.1    Loughlin, S.E.2
  • 19
    • 0030029425 scopus 로고    scopus 로고
    • Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices
    • Frankiewicz, T., Potier, B., Bashir, Z.I., Collingridge, G.L., Parsons, C.G., 1996. Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices. Br. J. Pharmacol. 117, 689-697. (Pubitemid 26070246)
    • (1996) British Journal of Pharmacology , vol.117 , Issue.4 , pp. 689-697
    • Frankiewicz, T.1    Potier, B.2    Bashir, Z.I.3    Collingridge, G.L.4    Parsons, C.G.5
  • 20
    • 34547672741 scopus 로고    scopus 로고
    • Agonist concentration dependency of blocking kinetics but not equilibrium block of N-methyl-d-aspartate receptors by memantine
    • DOI 10.1016/j.neuropharm.2007.05.022, PII S002839080700161X
    • Gilling, K.E., Jatzke, C., Parsons, C.G., 2007. Agonist concentration dependency of blocking kinetics but not equilibrium block of N-methyl-D-aspartate receptors by memantine. Neuropharmacology 53, 415-420. (Pubitemid 47212248)
    • (2007) Neuropharmacology , vol.53 , Issue.3 , pp. 415-420
    • Gilling, K.E.1    Jatzke, C.2    Parsons, C.G.3
  • 21
    • 0031041530 scopus 로고    scopus 로고
    • Slowly triggered excitotoxicity occurs by necrosis in cortical cultures
    • DOI 10.1016/S0306-4522(96)00473-3, PII S0306452296004733
    • Gwag, B.J., Koh, J.Y., DeMaro, J.A., Ying, H.S., Jacquin, M., Choi, D.W., 1997. Slowly triggered excitotoxicity occurs by necrosis in cortical cultures. Neuroscience 77, 393-401. (Pubitemid 27079611)
    • (1997) Neuroscience , vol.77 , Issue.2 , pp. 393-401
    • Gwag, B.J.1    Koh, J.Y.2    Demaro, J.A.3    Ying, H.S.4    Jacquin, M.5    Choi, D.W.6
  • 22
    • 2542431131 scopus 로고    scopus 로고
    • Rationale for and use of NMDA receptor antagonists in Parkinson's disease
    • DOI 10.1016/j.pharmthera.2004.04.001, PII S016372580400049X
    • Hallett, P.J., Standaert, D.G., 2004. Rationale for and use of NMDA receptor antagonists in Parkinson's disease. Pharmacol. Ther. 102, 155-174. (Pubitemid 38681014)
    • (2004) Pharmacology and Therapeutics , vol.102 , Issue.2 , pp. 155-174
    • Hallett, P.J.1    Standaert, D.G.2
  • 23
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders
    • Hardingham, G.E., Bading, H., 2010. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat. Rev. Neurosci. 11, 682-696.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 24
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • DOI 10.1038/nn835
    • Hardingham, G.E., Fukunaga, Y., Bading, H., 2002. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5, 405-414. (Pubitemid 34454245)
    • (2002) Nature Neuroscience , vol.5 , Issue.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 26
    • 0008996143 scopus 로고    scopus 로고
    • Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: A quantitative microdialysis study
    • DOI 10.1023/A:1018856020583
    • Hesselink, M.B., De Boer, B.G., Breimer, D.D., Danysz, W., 1999. Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study. Pharm. Res. 16, 637-642. (Pubitemid 29227091)
    • (1999) Pharmaceutical Research , vol.16 , Issue.5 , pp. 637-642
    • Hesselink, M.B.1    De Boer, B.G.2    Breimer, D.D.3    Danysz, W.4
  • 27
    • 69449090194 scopus 로고    scopus 로고
    • Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration
    • Higley, M.J., Soler-Llavina, G.J., Sabatini, B.L., 2009. Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration. Nat. Neurosci. 12, 1121-1128.
    • (2009) Nat. Neurosci. , vol.12 , pp. 1121-1128
    • Higley, M.J.1    Soler-Llavina, G.J.2    Sabatini, B.L.3
  • 28
    • 0031784165 scopus 로고    scopus 로고
    • Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease
    • DOI 10.1002/ana.410440407
    • Hutchison, W.D., Allan, R.J., Opitz, H., Levy, R., Dostrovsky, J.O., Lang, A.E., Lozano, A.M., 1998. Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease. Ann. Neurol. 44, 622-628. (Pubitemid 28477849)
    • (1998) Annals of Neurology , vol.44 , Issue.4 , pp. 622-628
    • Hutchison, W.D.1    Allan, R.J.2    Opitz, H.3    Levy, R.4    Dostrovsky, J.O.5    Lang, A.E.6    Lozano, A.M.7
  • 29
    • 0032102850 scopus 로고    scopus 로고
    • Excitatory amino acid-induced degeneration of dendrites of catecholamine neurons in rat substantia nigra
    • DOI 10.1006/exnr.1998.6783
    • Johnson, S.M., Bywood, P.T., 1998. Excitatory amino acid-induced degeneration of dendrites of catecholamine neurons in rat substantia nigra. Exp. Neurol. 151, 229-236. (Pubitemid 28285903)
    • (1998) Experimental Neurology , vol.151 , Issue.2 , pp. 229-236
    • Johnson, S.M.1    Bywood, P.T.2
  • 30
    • 30844460987 scopus 로고    scopus 로고
    • Mechanism of action of memantine
    • DOI 10.1016/j.coph.2005.09.007, PII S1471489205001876
    • Johnson, J.W., Kotermanski, S.E., 2006. Mechanism of action of memantine. Curr. Opin. Pharmacol. 6, 61-67. (Pubitemid 43103820)
    • (2006) Current Opinion in Pharmacology , vol.6 , Issue.1 SPEC. ISSUE. , pp. 61-67
    • Johnson, J.W.1    Kotermanski, S.E.2
  • 31
    • 28244493418 scopus 로고    scopus 로고
    • Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones
    • DOI 10.1113/jphysiol.2005.095554
    • Jones, S., Gibb, A.J., 2005. Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones. J. Physiol. 569, 209-221. (Pubitemid 41701386)
    • (2005) Journal of Physiology , vol.569 , Issue.1 , pp. 209-221
    • Jones, S.1    Gibb, A.J.2
  • 32
    • 0036181719 scopus 로고    scopus 로고
    • Channel blockers acting at N-methyl-D-aspartate receptors: Differential effects of mutations in the vestibule and ion channel pore
    • DOI 10.1124/mol.61.3.533
    • Kashiwagi, K., Masuko, T., Nguyen, C.D., Kuno, T., Tanaka, I., Igarashi, K., Williams, K., 2002. Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore. Mol. Pharmacol. 61 (3), 533-545. (Pubitemid 34171919)
    • (2002) Molecular Pharmacology , vol.61 , Issue.3 , pp. 533-545
    • Kashiwagi, K.1    Masuko, T.2    Nguyen, C.D.3    Kuno, T.4    Tanaka, I.5    Igarashi, K.6    Williams, K.7
  • 33
    • 0036830627 scopus 로고    scopus 로고
    • NMDA receptor pathways as drug targets
    • DOI 10.1038/nn936
    • Kemp, J.A., McKernan, R.M., 2002. NMDA receptor pathways as drug targets. Nat. Neurosci. 5, 1039-1042. (Pubitemid 35247194)
    • (2002) Nature Neuroscience , vol.5 , Issue.SUPPL. , pp. 1039-1042
    • Kemp, J.A.1    McKernan, R.M.2
  • 34
    • 63849213773 scopus 로고    scopus 로고
    • 2+ imparts NMDA receptor subtype selectivity to the alzheimer's drug memantine
    • 2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine. J. Neurosci. 29, 2774-2779.
    • (2009) J. Neurosci. , vol.29 , pp. 2774-2779
    • Kotermanski, S.E.1    Johnson, J.W.2
  • 36
    • 34249099711 scopus 로고    scopus 로고
    • NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
    • DOI 10.1038/nrn2153, PII NRN2153
    • Lau, C.G., Zukin, R.S., 2007. NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat. Rev. Neurosci. 8, 413-426. (Pubitemid 46789232)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.6 , pp. 413-426
    • Lau, C.G.1    Zukin, R.S.2
  • 37
    • 15044338779 scopus 로고    scopus 로고
    • Failures and Successes of NMDA Receptor Antagonists: Molecular Basis for the Use of Open-Channel Blockers like Memantine in the Treatment of Acute and Chronic Neurologic Insults
    • DOI 10.1602/neurorx.1.1.101, PII S1545534306700104
    • Lipton, S.A., 2004. Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. NeuroRx 1, 101-110. (Pubitemid 46589343)
    • (2004) NeuroRx , vol.1 , Issue.1 , pp. 101-110
    • Lipton, S.A.1
  • 38
    • 33645095476 scopus 로고    scopus 로고
    • Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
    • Lipton, S.A., 2006. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat. Rev. Drug Discov. 5, 160-170.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 160-170
    • Lipton, S.A.1
  • 39
    • 34648843243 scopus 로고    scopus 로고
    • Pathologically activated therapeutics for neuroprotection
    • DOI 10.1038/nrn2229, PII NRN2229
    • Lipton, S.A., 2007. Pathologically activated therapeutics for neuroprotection. Nat. Rev. Neurosci. 8, 803-808. (Pubitemid 47462118)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.10 , pp. 803-808
    • Lipton, S.A.1
  • 40
    • 34447625042 scopus 로고    scopus 로고
    • The sequence of events that underlie quantal transmission at central glutamatergic synapses
    • DOI 10.1038/nrn2191, PII NRN2191
    • Lisman, J.E., Raghavachari, S., Tsien, R.W., 2007. The sequence of events that underlie quantal transmission at central glutamatergic synapses. Nat. Rev. Neurosci. 8, 597-609. (Pubitemid 47093933)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.8 , pp. 597-609
    • Lisman, J.E.1    Raghavachari, S.2    Tsien, R.W.3
  • 41
    • 77949262274 scopus 로고    scopus 로고
    • Use of memantine (akatinol) for the correction of cognitive impairments in parkinson's disease complicated by dementia
    • Litvinenko, I.V., Odinak, M.M., Mogil'naya, V.I., Perstnev, S.V., 2010. Use of memantine (akatinol) for the correction of cognitive impairments in Parkinson's disease complicated by dementia. Neurosci. Behav. Physiol. 40, 149-155.
    • (2010) Neurosci. Behav. Physiol. , vol.40 , pp. 149-155
    • Litvinenko, I.V.1    Odinak, M.M.2    Mogil'naya, V.I.3    Perstnev, S.V.4
  • 45
    • 0034008610 scopus 로고    scopus 로고
    • Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients
    • DOI 10.1016/S0306-4522(99)00583-7, PII S0306452299005837
    • Magnin, M., Morel, A., Jeanmonod, D., 2000. Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients. Neuroscience 96, 549-564. (Pubitemid 30136320)
    • (2000) Neuroscience , vol.96 , Issue.3 , pp. 549-564
    • Magnin, M.1    Morel, A.2    Jeanmonod, D.3
  • 46
    • 33845305449 scopus 로고    scopus 로고
    • The ventral tegmental area revisited: Is there an electrophysiological marker for dopaminergic neurons?
    • DOI 10.1113/jphysiol.2006.117069
    • Margolis, E.B., Lock, H., Hjelmstad, G.O., Fields, H.L., 2006. The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? J. Physiol. 577, 907-924. (Pubitemid 44873655)
    • (2006) Journal of Physiology , vol.577 , Issue.3 , pp. 907-924
    • Margolis, E.B.1    Lock, H.2    Hjelmstad, G.O.3    Fields, H.L.4
  • 47
    • 84861185702 scopus 로고    scopus 로고
    • NMDA alters rotenone toxicity in rat substantia nigra zona compacta and ventral tegmental area dopamine neurons
    • Munhall, A.C., Wu, Y.N., Belknap, J.K., Meshul, C.K., Johnson, S.W., 2012. NMDA alters rotenone toxicity in rat substantia nigra zona compacta and ventral tegmental area dopamine neurons. Neurotoxicology 33, 429-435.
    • (2012) Neurotoxicology , vol.33 , pp. 429-435
    • Munhall, A.C.1    Wu, Y.N.2    Belknap, J.K.3    Meshul, C.K.4    Johnson, S.W.5
  • 48
    • 0037083312 scopus 로고    scopus 로고
    • h channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain
    • Neuhoff, H., Neu, A., Liss, B., Roeper, J., 2002. I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. J. Neurosci. 22, 1290-1302. (Pubitemid 34163731)
    • (2002) Journal of Neuroscience , vol.22 , Issue.4 , pp. 1290-1302
    • Neuhoff, H.1    Neu, A.2    Liss, B.3    Roeper, J.4
  • 51
    • 52449098734 scopus 로고    scopus 로고
    • Blocking kinetics of memantine on NR1a/2A receptors recorded in inside-out and outside-out patches from xenopus oocytes
    • Parsons, C.G., Gilling, K.E., Jatzke, C., 2008. Blocking kinetics of memantine on NR1a/2A receptors recorded in inside-out and outside-out patches from Xenopus oocytes. J. Neural Transm. 115, 1367-1373, 1996.
    • (1996) J. Neural Transm. , vol.115 , pp. 1367-1373
    • Parsons, C.G.1    Gilling, K.E.2    Jatzke, C.3
  • 52
    • 34948842904 scopus 로고    scopus 로고
    • Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse
    • DOI 10.1016/j.neuropharm.2007.07.013, PII S0028390807002298
    • Parsons, C.G., Stöffler, A., Danysz, W., 2007. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 53, 699-723. (Pubitemid 47532143)
    • (2007) Neuropharmacology , vol.53 , Issue.6 , pp. 699-723
    • Parsons, C.G.1    Stoffler, A.2    Danysz, W.3
  • 56
    • 0026701318 scopus 로고
    • Efficacy of memantine, an NMDA receptor antagonist, in the treatment of parkinson's disease
    • Rabey, J.M., Nissipeanu, P., Korczyn, A.D., 1992. Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease. J. Neural Transm. Park. Dis. Dement. Sect. 4, 277-282.
    • (1992) J. Neural Transm. Park. Dis. Dement. Sect. , vol.4 , pp. 277-282
    • Rabey, J.M.1    Nissipeanu, P.2    Korczyn, A.D.3
  • 57
    • 0345647098 scopus 로고    scopus 로고
    • Glutamate neurotoxicity in mouse cortical neurons: Atypical necrosis with DNA ladders and chromatin condensation
    • DOI 10.1016/S0304-3940(97)00936-1, PII S0304394097009361
    • Sohn, S., Kim, E.Y., Gwag, B.J., 1998. Glutamate neurotoxicity in mouse cortical neurons: atypical necrosis with DNA ladders and chromatin condensation. Neurosci. Lett. 240, 147-150. (Pubitemid 28079043)
    • (1998) Neuroscience Letters , vol.240 , Issue.3 , pp. 147-150
    • Sohn, S.1    Kim, E.Y.2    Gwag, B.J.3
  • 59
    • 77955129538 scopus 로고    scopus 로고
    • Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones
    • Suárez, F., Zhao, Q., Monaghan, D.T., Jane, D.E., Jones, S., Gibb, A.J., 2010. Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones. Eur. J. Neurosci. 32, 359-367.
    • (2010) Eur. J. Neurosci. , vol.32 , pp. 359-367
    • Suárez, F.1    Zhao, Q.2    Monaghan, D.T.3    Jane, D.E.4    Jones, S.5    Gibb, A.J.6
  • 60
    • 33744500234 scopus 로고    scopus 로고
    • Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity
    • DOI 10.1111/j.1460-9568.2006.04787.x
    • Volbracht, C., Van Beek, J., Zhu, C., Blomgren, K., Leist, M., 2006. Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity. Eur. J. Neurosci. 23, 2611-2622. (Pubitemid 43801453)
    • (2006) European Journal of Neuroscience , vol.23 , Issue.10 , pp. 2611-2622
    • Volbracht, C.1    Van Beek, J.2    Zhu, C.3    Blomgren, K.4    Leist, M.5
  • 61
    • 0037672691 scopus 로고    scopus 로고
    • Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine
    • De Vry, J., Jentzsch, K.R., 2003. Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine. Behav. Pharmacol. 14, 229-235. (Pubitemid 36735156)
    • (2003) Behavioural Pharmacology , vol.14 , Issue.3 , pp. 229-235
    • De Vry, J.1    Jentzsch, K.R.2
  • 62
    • 0032813188 scopus 로고    scopus 로고
    • Early postnatal development of substantia nigra neurons in rat midbrain slices: Hyperpolarization-activated inward current and dopamine-activated current
    • DOI 10.1016/S0168-0102(99)00039-5, PII S0168010299000395
    • Washio, H., Takigachi-Hayashi, K., Konishi, S., 1999. Early postnatal development of substantia nigra neurons in rat midbrain slices: hyperpolarization-activated inward current and dopamine-activated current. Neurosci. Res. 34, 91-101. (Pubitemid 29378297)
    • (1999) Neuroscience Research , vol.34 , Issue.2 , pp. 91-101
    • Washio, H.1    Takigachi-Hayashi, K.2    Konishi, S.3
  • 63
    • 21344459460 scopus 로고    scopus 로고
    • Blockade of NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats
    • Wedzony, K., Fija1, K., Chocyk, A., 2005. Blockade of NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats. J. Physiol. Pharmacol. 56, 205-221. (Pubitemid 40911088)
    • (2005) Journal of Physiology and Pharmacology , vol.56 , Issue.2 , pp. 205-221
    • Wedzony, K.1    Fijal, K.2    Chocyk, A.3
  • 64
    • 84860689529 scopus 로고    scopus 로고
    • Synaptic NMDA receptors mediate hypoxic excitotoxic death
    • Wroge, C.M., Hogins, J., Eisenman, L., Mennerick, S., 2012. Synaptic NMDA receptors mediate hypoxic excitotoxic death. J. Neurosci. 32, 6732-6742.
    • (2012) J. Neurosci. , vol.32 , pp. 6732-6742
    • Wroge, C.M.1    Hogins, J.2    Eisenman, L.3    Mennerick, S.4
  • 65
    • 77955855654 scopus 로고    scopus 로고
    • Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses
    • Xia, P., Chen, H.-S.V., Zhang, D., Lipton, S.A., 2010. Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J. Neurosci. 30, 11246-11250.
    • (2010) J. Neurosci. , vol.30 , pp. 11246-11250
    • Xia, P.1    Chen, H.-S.V.2    Zhang, D.3    Lipton, S.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.