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Volumn 6, Issue 6, 2014, Pages 548-558

Synthetic virology: Engineering viruses for gene delivery

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; GENE THERAPY; GENE TRANSFER; NANOPARTICLES; NATURAL POLYMERS; VECTORS;

EID: 84907876259     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.1287     Document Type: Review
Times cited : (42)

References (72)
  • 1
    • 84866899464 scopus 로고    scopus 로고
    • Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union
    • Yla-Herttuala S. Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union. Mol Ther 2012, 20:1831-1832.
    • (2012) Mol Ther , vol.20 , pp. 1831-1832
    • Yla-Herttuala, S.1
  • 2
    • 84859440283 scopus 로고    scopus 로고
    • The AAV vector toolkit: poised at the clinical crossroads
    • Asokan A, Schaffer DV, Samulski RJ. The AAV vector toolkit: poised at the clinical crossroads. Mol Ther 2012, 20:699-708.
    • (2012) Mol Ther , vol.20 , pp. 699-708
    • Asokan, A.1    Schaffer, D.V.2    Samulski, R.J.3
  • 4
    • 71849083415 scopus 로고    scopus 로고
    • Synthetic viruses: a new opportunity to understand and prevent viral disease
    • Wimmer E, Mueller S, Tumpey TM, Taubenberger JK. Synthetic viruses: a new opportunity to understand and prevent viral disease. Nat Biotechnol 2009, 27:1163-1172.
    • (2009) Nat Biotechnol , vol.27 , pp. 1163-1172
    • Wimmer, E.1    Mueller, S.2    Tumpey, T.M.3    Taubenberger, J.K.4
  • 5
    • 62649117859 scopus 로고    scopus 로고
    • Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis
    • Mueller S, Coleman JR, Wimmer E. Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis. Chem Biol 2009, 16:337-347.
    • (2009) Chem Biol , vol.16 , pp. 337-347
    • Mueller, S.1    Coleman, J.R.2    Wimmer, E.3
  • 6
    • 33746874152 scopus 로고    scopus 로고
    • Adeno-associated virus serotypes: vector toolkit for human gene therapy
    • Wu Z, Asokan A, Samulski RJ. Adeno-associated virus serotypes: vector toolkit for human gene therapy. Mol Ther 2006, 14:316-327.
    • (2006) Mol Ther , vol.14 , pp. 316-327
    • Wu, Z.1    Asokan, A.2    Samulski, R.J.3
  • 8
    • 84873246408 scopus 로고    scopus 로고
    • An adenovirus vector incorporating carbohydrate binding domains utilizes glycans for gene transfer
    • Kim JW, Glasgow JN, Nakayama M, Ak F, Ugai H, Curiel DT. An adenovirus vector incorporating carbohydrate binding domains utilizes glycans for gene transfer. PLoS One 2013, 8:e55533.
    • (2013) PLoS One , vol.8 , pp. e55533
    • Kim, J.W.1    Glasgow, J.N.2    Nakayama, M.3    Ak, F.4    Ugai, H.5    Curiel, D.T.6
  • 10
    • 84890953395 scopus 로고    scopus 로고
    • SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption
    • Ho ML, Adler BA, Torre ML, Silberg JJ, Suh J. SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption. ACS Synth Biol 2013, 2:724-733.
    • (2013) ACS Synth Biol , vol.2 , pp. 724-733
    • Ho, M.L.1    Adler, B.A.2    Torre, M.L.3    Silberg, J.J.4    Suh, J.5
  • 13
    • 84906774312 scopus 로고    scopus 로고
    • Efficiency of protease-activatable virus nanonodes tuned through incorporation of wild-type capsid subunits
    • (Special Issue on Young Innovators).
    • Ho ML, Judd J, Kuypers BE, Yamagami M, Wong FF, Suh J. Efficiency of protease-activatable virus nanonodes tuned through incorporation of wild-type capsid subunits. Cell Mol Bioeng 2014. doi:10.1007/s12195-014-0334-y (Special Issue on Young Innovators).
    • (2014) Cell Mol Bioeng
    • Ho, M.L.1    Judd, J.2    Kuypers, B.E.3    Yamagami, M.4    Wong, F.F.5    Suh, J.6
  • 14
    • 0033960160 scopus 로고    scopus 로고
    • Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes
    • Halbert CL, Rutledge EA, Allen JM, Russell DW, Miller AD. Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes. J Virol 2000, 74:1524-1532.
    • (2000) J Virol , vol.74 , pp. 1524-1532
    • Halbert, C.L.1    Rutledge, E.A.2    Allen, J.M.3    Russell, D.W.4    Miller, A.D.5
  • 15
    • 22944458202 scopus 로고    scopus 로고
    • Altering the tropism of lentiviral vectors through pseudotyping
    • Cronin J, Zhang XY, Reiser J. Altering the tropism of lentiviral vectors through pseudotyping. Curr Gene Ther 2005, 5:387-398.
    • (2005) Curr Gene Ther , vol.5 , pp. 387-398
    • Cronin, J.1    Zhang, X.Y.2    Reiser, J.3
  • 20
    • 44949131860 scopus 로고    scopus 로고
    • In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses
    • Grimm D, Lee JS, Wang L, Desai T, Akache B, Storm TA, Kay MA. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. J Virol 2008, 82:5887-5911.
    • (2008) J Virol , vol.82 , pp. 5887-5911
    • Grimm, D.1    Lee, J.S.2    Wang, L.3    Desai, T.4    Akache, B.5    Storm, T.A.6    Kay, M.A.7
  • 21
    • 77649273563 scopus 로고    scopus 로고
    • Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
    • Gray SJ, Blake BL, Criswell HE, Nicolson SC, Samulski RJ, McCown TJ. Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB). Mol Ther 2010, 18:570-578.
    • (2010) Mol Ther , vol.18 , pp. 570-578
    • Gray, S.J.1    Blake, B.L.2    Criswell, H.E.3    Nicolson, S.C.4    Samulski, R.J.5    McCown, T.J.6
  • 22
    • 54849391500 scopus 로고    scopus 로고
    • DNA shuffling of adeno-associated virus yields functionally diverse viral progeny
    • Koerber JT, Jang JH, Schaffer DV. DNA shuffling of adeno-associated virus yields functionally diverse viral progeny. Mol Ther 2008, 16:1703-1709.
    • (2008) Mol Ther , vol.16 , pp. 1703-1709
    • Koerber, J.T.1    Jang, J.H.2    Schaffer, D.V.3
  • 24
    • 0028050350 scopus 로고
    • Rapid evolution of a protein in-vitro by DNA shuffling
    • Stemmer WPC. Rapid evolution of a protein in-vitro by DNA shuffling. Nature 1994, 370:389-391.
    • (1994) Nature , vol.370 , pp. 389-391
    • Stemmer, W.P.C.1
  • 25
    • 0031909113 scopus 로고    scopus 로고
    • Molecular evolution by staggered extension process (StEP) in vitro recombination
    • Zhao HM, Giver L, Shao ZX, Affholter JA, Arnold FH. Molecular evolution by staggered extension process (StEP) in vitro recombination. Nat Biotechnol 1998, 16:258-261.
    • (1998) Nat Biotechnol , vol.16 , pp. 258-261
    • Zhao, H.M.1    Giver, L.2    Shao, Z.X.3    Affholter, J.A.4    Arnold, F.H.5
  • 29
    • 0033851104 scopus 로고    scopus 로고
    • Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism
    • Wu P, Xiao W, Conlon T, Hughes J, Agbandje-McKenna M, Ferkol T, Flotte T, Muzyczka N. Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism. J Virol 2000, 74:8635-8647.
    • (2000) J Virol , vol.74 , pp. 8635-8647
    • Wu, P.1    Xiao, W.2    Conlon, T.3    Hughes, J.4    Agbandje-McKenna, M.5    Ferkol, T.6    Flotte, T.7    Muzyczka, N.8
  • 30
    • 0033590138 scopus 로고    scopus 로고
    • Insertional mutagenesis of AAV2 capsid and the production of recombinant virus
    • Rabinowitz JE, Xiao W, Samulski RJ. Insertional mutagenesis of AAV2 capsid and the production of recombinant virus. Virology 1999, 265:274-285.
    • (1999) Virology , vol.265 , pp. 274-285
    • Rabinowitz, J.E.1    Xiao, W.2    Samulski, R.J.3
  • 31
    • 60949103263 scopus 로고    scopus 로고
    • Adeno-associated virus-2 and its primary cellular receptor-Cryo-EM structure of a heparin complex
    • O'Donnell J, Taylor KA, Chapman MS. Adeno-associated virus-2 and its primary cellular receptor-Cryo-EM structure of a heparin complex. Virology 2009, 385:434-443.
    • (2009) Virology , vol.385 , pp. 434-443
    • O'Donnell, J.1    Taylor, K.A.2    Chapman, M.S.3
  • 34
    • 67449093868 scopus 로고    scopus 로고
    • In vivo retargeting of adenovirus type 5 to alpha v beta 6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery
    • Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR, Thomas GJ. In vivo retargeting of adenovirus type 5 to alpha v beta 6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery. J Virol 2009, 83:6416-6428.
    • (2009) J Virol , vol.83 , pp. 6416-6428
    • Coughlan, L.1    Vallath, S.2    Saha, A.3    Flak, M.4    McNeish, I.A.5    Vassaux, G.6    Marshall, J.F.7    Hart, I.R.8    Thomas, G.J.9
  • 37
    • 60449093710 scopus 로고    scopus 로고
    • Re-targeted adenovirus vectors with dual specificity; binding specificities conferred by two different Affibody molecules in the fiber
    • Myhre S, Henning P, Friedman M, Stahl S, Lindholm L, Magnusson MK. Re-targeted adenovirus vectors with dual specificity; binding specificities conferred by two different Affibody molecules in the fiber. Gene Ther 2009, 16:252-261.
    • (2009) Gene Ther , vol.16 , pp. 252-261
    • Myhre, S.1    Henning, P.2    Friedman, M.3    Stahl, S.4    Lindholm, L.5    Magnusson, M.K.6
  • 39
    • 2642565909 scopus 로고    scopus 로고
    • Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus
    • Warrington KH Jr, Gorbatyuk OS, Harrison JK, Opie SR, Zolotukhin S, Muzyczka N. Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus. J Virol 2004, 78:6595-6609.
    • (2004) J Virol , vol.78 , pp. 6595-6609
    • Warrington Jr., K.H.1    Gorbatyuk, O.S.2    Harrison, J.K.3    Opie, S.R.4    Zolotukhin, S.5    Muzyczka, N.6
  • 40
    • 84871928310 scopus 로고    scopus 로고
    • Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer
    • Munch RC, Janicki H, Volker I, Rasbach A, Hallek M, Buning H, Buchholz CJ. Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer. Mol Ther 2013, 21:109-118.
    • (2013) Mol Ther , vol.21 , pp. 109-118
    • Munch, R.C.1    Janicki, H.2    Volker, I.3    Rasbach, A.4    Hallek, M.5    Buning, H.6    Buchholz, C.J.7
  • 41
    • 33746833330 scopus 로고    scopus 로고
    • Targeting lentiviral vectors to specific cell types in vivo
    • Yang L, Bailey L, Baltimore D, Wang P. Targeting lentiviral vectors to specific cell types in vivo. Proc Natl Acad Sci U S A 2006, 103:11479-11484.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11479-11484
    • Yang, L.1    Bailey, L.2    Baltimore, D.3    Wang, P.4
  • 42
    • 77949886815 scopus 로고    scopus 로고
    • Progress in phage display: evolution of the technique and its applications
    • Bratkovic T. Progress in phage display: evolution of the technique and its applications. Cell Mol Life Sci 2010, 67:749-767.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 749-767
    • Bratkovic, T.1
  • 43
    • 0036194485 scopus 로고    scopus 로고
    • Altering retroviral tropism using a random-display envelope library
    • Bupp K, Roth MJ. Altering retroviral tropism using a random-display envelope library. Mol Ther 2002, 5:329-335.
    • (2002) Mol Ther , vol.5 , pp. 329-335
    • Bupp, K.1    Roth, M.J.2
  • 44
    • 84907874015 scopus 로고    scopus 로고
    • Transductionally-retargeted infectivity selective oncolytic adenovirus with redesigned AB-loop targeting cell surface mesothelin
    • Miura Y, Davydova J, Yamamoto M. Transductionally-retargeted infectivity selective oncolytic adenovirus with redesigned AB-loop targeting cell surface mesothelin. Mol Ther 2012, 20:S210-S211.
    • (2012) Mol Ther , vol.20 , pp. S210-S211
    • Miura, Y.1    Davydova, J.2    Yamamoto, M.3
  • 45
    • 84866651410 scopus 로고    scopus 로고
    • Development of peritoneal tumor-targeting vector by in vivo screening with a random peptide-displaying adenovirus library
    • Nishimoto T, Yamamoto Y, Yoshida K, Goto N, Ohnami S, Aoki K. Development of peritoneal tumor-targeting vector by in vivo screening with a random peptide-displaying adenovirus library. PLoS One 2012, 7:e45550.
    • (2012) PLoS One , vol.7 , pp. e45550
    • Nishimoto, T.1    Yamamoto, Y.2    Yoshida, K.3    Goto, N.4    Ohnami, S.5    Aoki, K.6
  • 47
    • 77955654722 scopus 로고    scopus 로고
    • Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library
    • Ying Y, Muller OJ, Goehringer C, Leuchs B, Trepel M, Katus HA, Kleinschmidt JA. Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library. Gene Ther 2010, 17:980-990.
    • (2010) Gene Ther , vol.17 , pp. 980-990
    • Ying, Y.1    Muller, O.J.2    Goehringer, C.3    Leuchs, B.4    Trepel, M.5    Katus, H.A.6    Kleinschmidt, J.A.7
  • 50
    • 84934444639 scopus 로고    scopus 로고
    • Transposon-based mutagenesis generates diverse adeno-associated viral libraries with novel gene delivery properties
    • Koerber JT, Schaffer DV. Transposon-based mutagenesis generates diverse adeno-associated viral libraries with novel gene delivery properties. Methods Mol Biol 2008, 434:161-170.
    • (2008) Methods Mol Biol , vol.434 , pp. 161-170
    • Koerber, J.T.1    Schaffer, D.V.2
  • 51
    • 32344438754 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
    • Maheshri N, Koerber JT, Kaspar BK, Schaffer DV. Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nat Biotechnol 2006, 24:198-204.
    • (2006) Nat Biotechnol , vol.24 , pp. 198-204
    • Maheshri, N.1    Koerber, J.T.2    Kaspar, B.K.3    Schaffer, D.V.4
  • 52
    • 32844470411 scopus 로고    scopus 로고
    • Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus
    • Perabo L, Endell J, King S, Lux K, Goldnau D, Hallek M, Buning H. Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus. J Gene Med 2006, 8:155-162.
    • (2006) J Gene Med , vol.8 , pp. 155-162
    • Perabo, L.1    Endell, J.2    King, S.3    Lux, K.4    Goldnau, D.5    Hallek, M.6    Buning, H.7
  • 53
    • 84856546741 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells
    • Asuri P, Bartel MA, Vazin T, Jang JH, Wong TB, Schaffer DV. Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells. Mol Ther 2012, 20:329-338.
    • (2012) Mol Ther , vol.20 , pp. 329-338
    • Asuri, P.1    Bartel, M.A.2    Vazin, T.3    Jang, J.H.4    Wong, T.B.5    Schaffer, D.V.6
  • 57
    • 33646821738 scopus 로고    scopus 로고
    • Metabolic biotinylation provides a unique platform for the purification and targeting of multiple AAV vector serotypes
    • Arnold GS, Sasser AK, Stachler MD, Bartlett JS. Metabolic biotinylation provides a unique platform for the purification and targeting of multiple AAV vector serotypes. Mol Ther 2006, 14:97-106.
    • (2006) Mol Ther , vol.14 , pp. 97-106
    • Arnold, G.S.1    Sasser, A.K.2    Stachler, M.D.3    Bartlett, J.S.4
  • 59
    • 48349091919 scopus 로고    scopus 로고
    • Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase
    • Stachler MD, Chen I, Ting AY, Bartlett JS. Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase. Mol Ther 2008, 16:1467-1473.
    • (2008) Mol Ther , vol.16 , pp. 1467-1473
    • Stachler, M.D.1    Chen, I.2    Ting, A.Y.3    Bartlett, J.S.4
  • 60
    • 84873366065 scopus 로고    scopus 로고
    • Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag
    • Liu YR, Fang Y, Zhou Y, Zandi E, Lee CL, Joo KI, Wang P. Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag. Small 2013, 9:421-429.
    • (2013) Small , vol.9 , pp. 421-429
    • Liu, Y.R.1    Fang, Y.2    Zhou, Y.3    Zandi, E.4    Lee, C.L.5    Joo, K.I.6    Wang, P.7
  • 61
    • 84859422819 scopus 로고    scopus 로고
    • Conjugation of paclitaxel on adeno-associated virus (AAV) nanoparticles for co-delivery of genes and drugs
    • Wei F, McConnell KI, Yu TK, Suh J. Conjugation of paclitaxel on adeno-associated virus (AAV) nanoparticles for co-delivery of genes and drugs. Eur J Pharm Sci 2012, 46:167-172.
    • (2012) Eur J Pharm Sci , vol.46 , pp. 167-172
    • Wei, F.1    McConnell, K.I.2    Yu, T.K.3    Suh, J.4
  • 62
    • 73249114207 scopus 로고    scopus 로고
    • Genome-free viral capsids as multivalent carriers for taxol delivery
    • Wu W, Hsiao SC, Carrico ZM, Francis MB. Genome-free viral capsids as multivalent carriers for taxol delivery. Angew Chem Int Ed Engl 2009, 48:9493-9497.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 9493-9497
    • Wu, W.1    Hsiao, S.C.2    Carrico, Z.M.3    Francis, M.B.4
  • 63
    • 77956036859 scopus 로고    scopus 로고
    • Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives
    • Knop K, Hoogenboom R, Fischer D, Schubert US. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed Engl 2010, 49:6288-6308.
    • (2010) Angew Chem Int Ed Engl , vol.49 , pp. 6288-6308
    • Knop, K.1    Hoogenboom, R.2    Fischer, D.3    Schubert, U.S.4
  • 64
    • 65249114149 scopus 로고    scopus 로고
    • PEGylated viral nanoparticles for biomedicine: the impact of PEG chain length on VNP cell interactions in vitro and ex vivo
    • Steinmetz NF, Manchester M. PEGylated viral nanoparticles for biomedicine: the impact of PEG chain length on VNP cell interactions in vitro and ex vivo. Biomacromolecules 2009, 10:784-792.
    • (2009) Biomacromolecules , vol.10 , pp. 784-792
    • Steinmetz, N.F.1    Manchester, M.2
  • 65
    • 27844563357 scopus 로고    scopus 로고
    • PEG conjugation moderately protects adeno-associated viral vectors against antibody neutralization
    • Lee GK, Maheshri N, Kaspar B, Schaffer DV. PEG conjugation moderately protects adeno-associated viral vectors against antibody neutralization. Biotechnol Bioeng 2005, 92:24-34.
    • (2005) Biotechnol Bioeng , vol.92 , pp. 24-34
    • Lee, G.K.1    Maheshri, N.2    Kaspar, B.3    Schaffer, D.V.4
  • 66
    • 34848845849 scopus 로고    scopus 로고
    • Polyethylene glycol modification of adenovirus reduces platelet activation, endothelial cell activation, and thrombocytopenia
    • Hofherr SE, Mok H, Gushiken FC, Lopez JA, Barry MA. Polyethylene glycol modification of adenovirus reduces platelet activation, endothelial cell activation, and thrombocytopenia. Hum Gene Ther 2007, 18:837-848.
    • (2007) Hum Gene Ther , vol.18 , pp. 837-848
    • Hofherr, S.E.1    Mok, H.2    Gushiken, F.C.3    Lopez, J.A.4    Barry, M.A.5
  • 67
    • 76749157350 scopus 로고    scopus 로고
    • Physical adsorption of PEG grafted and blocked poly-L-lysine copolymers on adenovirus surface for enhanced gene transduction
    • Park JW, Mok H, Park TG. Physical adsorption of PEG grafted and blocked poly-L-lysine copolymers on adenovirus surface for enhanced gene transduction. J Control Release 2010, 142:238-244.
    • (2010) J Control Release , vol.142 , pp. 238-244
    • Park, J.W.1    Mok, H.2    Park, T.G.3
  • 68
    • 77149154950 scopus 로고    scopus 로고
    • Combination of adenovirus and cross-linked low molecular weight PEI improves efficiency of gene transduction
    • Han JF, Zhao D, Zhong ZR, Zhang ZR, Gong T, Sun X. Combination of adenovirus and cross-linked low molecular weight PEI improves efficiency of gene transduction. Nanotechnology 2010, 21:105106-105115.
    • (2010) Nanotechnology , vol.21 , pp. 105106-105115
    • Han, J.F.1    Zhao, D.2    Zhong, Z.R.3    Zhang, Z.R.4    Gong, T.5    Sun, X.6
  • 71
    • 80051531016 scopus 로고    scopus 로고
    • Enhanced real-time monitoring of adeno-associated virus trafficking by virus-quantum dot conjugates
    • Joo KI, Fang Y, Liu YR, Xiao L, Gu Z, Tai A, Lee CL, Tang Y, Wang P. Enhanced real-time monitoring of adeno-associated virus trafficking by virus-quantum dot conjugates. ACS Nano 2011, 5:3523-3535.
    • (2011) ACS Nano , vol.5 , pp. 3523-3535
    • Joo, K.I.1    Fang, Y.2    Liu, Y.R.3    Xiao, L.4    Gu, Z.5    Tai, A.6    Lee, C.L.7    Tang, Y.8    Wang, P.9


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