In vivo retargeting of adenovirus type 5 to αvβ6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery

Journal of Virology

Volumn 83, Issue 13, 2009, Pages 6416-6428

  Coughlan, Lynda ^a   Vallath, Sabari ^a   Saha, Antonio ^a   Flak, Magdalena ^a   McNeish, Iain A ^a   Vassaux, Georges ^b   Marshall, John F ^a   Hart, Ian R ^a   Thomas, Gareth J ^a,c  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b HÔTEL DIEU   (France)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS 5 VECTOR; ADENOVIRUS VECTOR; ALANINE AMINOTRANSFERASE; ALPHAVBETA5 INTEGRIN; ALPHAVBETA6 INTEGRIN; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BLOOD CLOTTING FACTOR; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; E1A PROTEIN; ENHANCED GREEN FLUORESCENT PROTEIN; ENHANCED GREEN FLUORESCENT PROTEIN A20; ENHANCED GREEN FLUORESCENT PROTEIN WT; PEPTIDE DERIVATIVE; PROTEIN A20FMDV2; PROTEIN VP1; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; WARFARIN; CAPSID PROTEIN; CAR RECEPTOR; HEXON CAPSID PROTEIN, ADENOVIRUS; INTEGRIN; RECOMBINANT PROTEIN; TUMOR ANTIGEN; VIRUS RECEPTOR;

ADENOVIRUS 5; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG SELECTIVITY; DRUG TARGETING; DRUG TUMOR LEVEL; EPITHELIUM CELL; FEMALE; FOOT AND MOUTH DISEASE VIRUS; GENE TARGETING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; TUMOR GROWTH; TUMOR XENOGRAFT; UPREGULATION; VALIDATION PROCESS; VIRAL GENE DELIVERY SYSTEM; VIRUS GENOME; VIRUS RECOMBINANT; ADENOVIRUS; ANIMAL; GENE THERAPY; GENE VECTOR; GENETICS; METABOLISM; METHODOLOGY; NUDE MOUSE; ONCOLYTIC VIROTHERAPY; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; TUMOR CELL LINE;

ADENOVIRIDAE; COXSACKIEVIRUS; FOOT-AND-MOUTH DISEASE VIRUS; HUMAN ADENOVIRUS TYPE 5;

ADENOVIRIDAE; ANIMALS; ANTIGENS, NEOPLASM; CAPSID PROTEINS; CELL LINE, TUMOR; FEMALE; GENE THERAPY; GENETIC VECTORS; GENOME, VIRAL; HUMANS; INTEGRINS; MICE; MICE, NUDE; ONCOLYTIC VIROTHERAPY; PROTEIN BINDING; RECEPTORS, VIRUS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 67449093868     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00445-09     Document Type: Article

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