-
1
-
-
40449086359
-
Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
-
Atamna, H., Nguyen, A., Schultz, C., Boyle, K., Newberry, J., Kato, H.,et al. (2008). Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB J. 22, 703-712. doi: 10.1096/fj.07-9610com
-
(2008)
FASEB J.
, vol.22
, pp. 703-712
-
-
Atamna, H.1
Nguyen, A.2
Schultz, C.3
Boyle, K.4
Newberry, J.5
Kato, H.6
-
2
-
-
80055106822
-
Adult neural stem cells: Response to stroke injury and potential for therapeutic applications
-
Barkho, B. Z., and Zhao, X. (2011). Adult neural stem cells: response to stroke injury and potential for therapeutic applications. Curr. Stem Cell Res. Ther. 6, 327-338. doi: 10.2174/157488811797904362
-
(2011)
Curr. Stem Cell Res. Ther.
, vol.6
, pp. 327-338
-
-
Barkho, B.Z.1
Zhao, X.2
-
3
-
-
33847784791
-
Multiple levels of cyclin specificity in cell-cycle control
-
Bloom, J., and Cross, F. R. (2007). Multiple levels of cyclin specificity in cell-cycle control. Nat. Rev. Mol. Cell Biol.8, 149-160. doi: 10.1038/nrm2105
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 149-160
-
-
Bloom, J.1
Cross, F.R.2
-
4
-
-
69249206717
-
MTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
-
Castilho, R., Squarize, C., Chodosh, L., Williams, B., and Gutkind, J. (2009). mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 5, 279-289. doi: 10.1016/j.stem.2009.06.017
-
(2009)
Cell Stem Cell
, vol.5
, pp. 279-289
-
-
Castilho, R.1
Squarize, C.2
Chodosh, L.3
Williams, B.4
Gutkind, J.5
-
5
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K. L., and Zheng, P. (2008). TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205, 2397-2408. doi: 10.1084/jem.20081297
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
Liu, Y.2
Liu, R.3
Ikenoue, T.4
Guan, K.L.5
Zheng, P.6
-
6
-
-
75549090275
-
MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
-
Chen, C., Liu, Y., and Zheng, P. (2009). mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2, ra75. doi: 10.1126/scisignal.2000559
-
(2009)
Sci. Signal.
, vol.2
-
-
Chen, C.1
Liu, Y.2
Zheng, P.3
-
7
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
-
Cheng, T., Rodrigues, N., Shen, H., Yang, Y., Dombkowski, D., Sykes, M.,et al. (2000). Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804-1808. doi: 10.1126/science.287.5459.1804
-
(2000)
Science
, vol.287
, pp. 1804-1808
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
Yang, Y.4
Dombkowski, D.5
Sykes, M.6
-
8
-
-
84878240136
-
Molecular regulation of stem cell quiescence
-
Cheung, T. H., and Rando, T. A. (2013). Molecular regulation of stem cell quiescence. Nat. Rev. Mol. Cell Biol. 14, 329-340. doi: 10.1038/nrm3591
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 329-340
-
-
Cheung, T.H.1
Rando, T.A.2
-
9
-
-
84862281225
-
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo
-
Congdon, E. E., Wu, J. W., Myeku, N., Figueroa, Y. H., Herman, M.,et al. (2012). Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy 8, 609-622. doi: 10.4161/auto.19048
-
(2012)
Autophagy
, vol.8
, pp. 609-622
-
-
Congdon, E.E.1
Wu, J.W.2
Myeku, N.3
Figueroa, Y.H.4
Herman, M.5
-
10
-
-
84879028216
-
Efficacy of proveblue (methylene blue) in an experimental cerebral malaria murine model
-
Dormoi, J., Briolant, S., Desgrouas, C., and Pradines, B. (2013). Efficacy of proveblue (methylene blue) in an experimental cerebral malaria murine model. Antimicrob. Agents. Chemother. 57, 3412-3414. doi: 10.1128/AAC.02381-12
-
(2013)
Antimicrob. Agents. Chemother.
, vol.57
, pp. 3412-3414
-
-
Dormoi, J.1
Briolant, S.2
Desgrouas, C.3
Pradines, B.4
-
11
-
-
70350539313
-
Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation
-
El-Naggar, S., Liu, Y., and Dean, D. C. (2009). Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation. Mol. Cell. Biol. 29, 5710-5717. doi: 10.1128/MCB.00197-09
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 5710-5717
-
-
El-Naggar, S.1
Liu, Y.2
Dean, D.C.3
-
12
-
-
0345732640
-
MTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar, D. C., Richardson, C. J., Tee, A. R., Cheatham, L., Tsou, C., and Blenis, J. (2004). mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 24, 200-216. doi: 10.1128/MCB.24.1.200-216.2004
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
13
-
-
0034712047
-
Mammalian neural stem cells
-
Gage, F. (2000). Mammalian neural stem cells. Science 287, 1433-1438. doi: 10.1126/science.287.5457.1433
-
(2000)
Science
, vol.287
, pp. 1433-1438
-
-
Gage, F.1
-
14
-
-
84871484070
-
Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway
-
Han, J., Xiao, Z., Chen, L., Chen, B., Li, X., Han, S.,et al. (2013). Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway. Biomaterials34, 1921-1928. doi: 10.1016/j.biomaterials.2012.11.063
-
(2013)
Biomaterials
, vol.34
, pp. 1921-1928
-
-
Han, J.1
Xiao, Z.2
Chen, L.3
Chen, B.4
Li, X.5
Han, S.6
-
15
-
-
70350220586
-
Mechanisms of stem cell self-renewal
-
He, S., Nakada, D., and Morrison, S. J. (2009). Mechanisms of stem cell self-renewal. Annu. Rev. Cell Dev. Biol. 25, 377-406. doi: 10.1146/annurev.cellbio.042308.113248
-
(2009)
Annu. Rev. Cell Dev. Biol.
, vol.25
, pp. 377-406
-
-
He, S.1
Nakada, D.2
Morrison, S.J.3
-
16
-
-
0344559101
-
The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP
-
Imura, T., Kornblum, H. I., and Sofroniew, M. V. (2003). The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. J. Neurosci. 23, 2824-2832.
-
(2003)
J. Neurosci.
, vol.23
, pp. 2824-2832
-
-
Imura, T.1
Kornblum, H.I.2
Sofroniew, M.V.3
-
17
-
-
15444377643
-
P21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
-
Kippin, T., Martens, D., and van der Kooy, D. (2005). p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev. 19, 756-767. doi: 10.1101/gad.1272305
-
(2005)
Genes Dev.
, vol.19
, pp. 756-767
-
-
Kippin, T.1
Martens, D.2
van der Kooy, D.3
-
18
-
-
77953625257
-
Cdks and cyclins link G1 length and differentiation of embryonic, neural and hematopoietic stem cells
-
Lange, C., and Calegari, F. (2010). Cdks and cyclins link G1 length and differentiation of embryonic, neural and hematopoietic stem cells. Cell Cycle 9, 1893-1900. doi: 10.4161/cc.9.10.11598
-
(2010)
Cell Cycle
, vol.9
, pp. 1893-1900
-
-
Lange, C.1
Calegari, F.2
-
19
-
-
79955513612
-
Manifestations and mechanisms of stem cell aging
-
Liu, L., and Rando, T. A. (2011). Manifestations and mechanisms of stem cell aging. J. Cell Biol. 193, 257-266. doi: 10.1083/jcb.201010131
-
(2011)
J. Cell Biol.
, vol.193
, pp. 257-266
-
-
Liu, L.1
Rando, T.A.2
-
20
-
-
84878864199
-
The hallmarks of aging
-
López-Otín, C., Blasco, M., Partridge, L., Serrano, M., and Kroemer, G. (2013). The hallmarks of aging. Cell 153, 1194-1217. doi: 10.1016/j.cell.2013.05.039
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
López-Otín, C.1
Blasco, M.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
21
-
-
80755141303
-
Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions
-
Magri, L., Cambiaghi, M., Cominelli, M., Alfaro-Cervello, C., Cursi, M., Pala, M.,et al. (2011). Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions. Cell Stem Cell 9, 447-462. doi: 10.1016/j.stem.2011.09.008
-
(2011)
Cell Stem Cell
, vol.9
, pp. 447-462
-
-
Magri, L.1
Cambiaghi, M.2
Cominelli, M.3
Alfaro-Cervello, C.4
Cursi, M.5
Pala, M.6
-
22
-
-
84889572662
-
MTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions
-
Matsubara, S., Ding, Q., Miyazaki, Y., Kuwahata, T., Tsukasa, K., and Takao, S. (2013). mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions. Sci. Rep. 3, 3230. doi: 10.1038/srep03230
-
(2013)
Sci. Rep.
, vol.3
, pp. 3230
-
-
Matsubara, S.1
Ding, Q.2
Miyazaki, Y.3
Kuwahata, T.4
Tsukasa, K.5
Takao, S.6
-
23
-
-
33144486282
-
Methylene blue for management of Ifosfamide-induced encephalopathy
-
Patel, P. N. (2006). Methylene blue for management of Ifosfamide-induced encephalopathy. Ann. Pharmacother.40, 299-303. doi: 10.1345/aph.1G114
-
(2006)
Ann. Pharmacother.
, vol.40
, pp. 299-303
-
-
Patel, P.N.1
-
24
-
-
84876004187
-
Reversing the Warburg effect as a treatment for glioblastoma
-
Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R.,et al. (2013). Reversing the Warburg effect as a treatment for glioblastoma. J. Biol. Chem. 288, 9153-9164. doi: 10.1074/jbc.M112.440354
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 9153-9164
-
-
Poteet, E.1
Choudhury, G.R.2
Winters, A.3
Li, W.4
Ryou, M.G.5
Liu, R.6
-
25
-
-
84868282410
-
Neuroprotective actions of methylene blue and its derivatives
-
Poteet, E., Winters, A., Yan, L. J., Shufelt, K., Green, K. N., Simpkins, J. W.,et al. (2012). Neuroprotective actions of methylene blue and its derivatives. PLoS ONE 7:e48279. doi: 10.1371/journal.pone.0048279
-
(2012)
PLoS ONE
, vol.7
-
-
Poteet, E.1
Winters, A.2
Yan, L.J.3
Shufelt, K.4
Green, K.N.5
Simpkins, J.W.6
-
26
-
-
70350506802
-
FoxO3 regulates neural stem cell homeostasis
-
Renault, V. M., Rafalski, V. A., Morgan, A. A., Salih, D. A., Brett, J. O., Webb, A. E.,et al. (2009). FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell 5, 527-539. doi: 10.1016/j.stem.2009.09.014
-
(2009)
Cell Stem Cell
, vol.5
, pp. 527-539
-
-
Renault, V.M.1
Rafalski, V.A.2
Morgan, A.A.3
Salih, D.A.4
Brett, J.O.5
Webb, A.E.6
-
27
-
-
80455143200
-
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
-
Rera, M., Bahadorani, S., Cho, J., Koehler, C., Ulgherait, M., Hur, J.,et al. (2011). Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab. 14, 623-634. doi: 10.1016/j.cmet.2011.09.013
-
(2011)
Cell Metab.
, vol.14
, pp. 623-634
-
-
Rera, M.1
Bahadorani, S.2
Cho, J.3
Koehler, C.4
Ulgherait, M.5
Hur, J.6
-
28
-
-
84875953755
-
Stem cell metabolism in tissue development and aging
-
Shyh-Chang, N., Daley, G. Q., and Cantley, L. C. (2013). Stem cell metabolism in tissue development and aging. Development 140, 2535-2547. doi: 10.1242/dev.091777
-
(2013)
Development
, vol.140
, pp. 2535-2547
-
-
Shyh-Chang, N.1
Daley, G.Q.2
Cantley, L.C.3
-
29
-
-
84886375160
-
Role of PI3K-AKT-mTOR and Wnt signaling pathways in transition of G1-S phase of cell cycle in cancer cells
-
Vadlakonda, L., Pasupuleti, M., and Pallu, R. (2013). Role of PI3K-AKT-mTOR and Wnt signaling pathways in transition of G1-S phase of cell cycle in cancer cells. Front. Oncol. 3:85. doi: 10.3389/fonc.2013.00085
-
(2013)
Front. Oncol.
, vol.3
, pp. 85
-
-
Vadlakonda, L.1
Pasupuleti, M.2
Pallu, R.3
-
30
-
-
79953298958
-
Next-generation mTOR inhibitors in clinical oncology: How pathway complexity informs therapeutic strategy
-
Wander, S. A., Hennessy, B. T., and Slingerland, J. M. (2011). Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J. Clin. Invest. 121, 1231-1241. doi: 10.1172/JCI44145
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 1231-1241
-
-
Wander, S.A.1
Hennessy, B.T.2
Slingerland, J.M.3
-
31
-
-
84901349234
-
Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency
-
Wang, S., Xia, P., Ye, B., Huang, G., Liu, J., and Fan, Z. (2013). Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell 13, 617-625. doi: 10.1016/j.stem.2013.10.005
-
(2013)
Cell Stem Cell
, vol.13
, pp. 617-625
-
-
Wang, S.1
Xia, P.2
Ye, B.3
Huang, G.4
Liu, J.5
Fan, Z.6
-
32
-
-
79955528923
-
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection
-
Wen, Y., Li, W., Poteet, E. C., Xie, L., Tan, C., Yan, L. J.,et al. (2011). Alternative mitochondrial electron transfer as a novel strategy for neuroprotection. J. Biol. Chem. 286, 16504-16515. doi: 10.1074/jbc.M110.208447
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16504-16515
-
-
Wen, Y.1
Li, W.2
Poteet, E.C.3
Xie, L.4
Tan, C.5
Yan, L.J.6
-
33
-
-
84876433114
-
Methylene blue induces macroautophagy through 5′ adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation
-
Xie, L., Li, W., Winters, A., Yuan, F., Jin, K., and Yang, S. (2013). Methylene blue induces macroautophagy through 5′ adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation. Front. Cell. Neurosci. 7:56. doi: 10.3389/fncel.2013.00056
-
(2013)
Front. Cell. Neurosci.
, vol.7
, pp. 56
-
-
Xie, L.1
Li, W.2
Winters, A.3
Yuan, F.4
Jin, K.5
Yang, S.6
-
34
-
-
84862994618
-
MTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
-
Yilmaz,Ö. H., Katajisto, P., Lamming, D., Gültekin, Y., Bauer-Rowe, K., Sengupta, S.,et al. (2012). mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 486, 490-495. doi: 10.1038/nature11163
-
(2012)
Nature
, vol.486
, pp. 490-495
-
-
Yilmaz, Ö.H.1
Katajisto, P.2
Lamming, D.3
Gültekin, Y.4
Bauer-Rowe, K.5
Sengupta, S.6
-
35
-
-
0035427979
-
Use of methylene blue to treat methemoglobinemia in infancy
-
Zenk, K. E. (2001). Use of methylene blue to treat methemoglobinemia in infancy. Neonatal Netw. 20, 62-68. doi: 10.1891/0730-0832.20.5.62
-
(2001)
Neonatal Netw.
, vol.20
, pp. 62-68
-
-
Zenk, K.E.1
-
36
-
-
66049149059
-
MTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells
-
Zhou, J., Su, P., Wang, L., Chen, J., Zimmermann, M., Genbacev, O.,et al. (2009). mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 106, 7840-7845. doi: 10.1073/pnas.0901854106
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 7840-7845
-
-
Zhou, J.1
Su, P.2
Wang, L.3
Chen, J.4
Zimmermann, M.5
Genbacev, O.6
|