-
1
-
-
67650966680
-
Microglia Physiology: Unique Stimuli, Specialized Responses
-
Ranshoff, R.M. P. V. H. Microglia Physiology: Unique Stimuli, Specialized Responses. Annu. Rev. Immunol. 27, 119-145 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 119-145
-
-
Ranshoff, R.M.P.V.H.1
-
2
-
-
0025220976
-
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
-
Lawson, L.J., Perry, V. H., Dri, P. & Gordon, S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience. 39, 151-170 (1990).
-
(1990)
Neuroscience.
, vol.39
, pp. 151-170
-
-
Lawson, L.J.1
Perry, V.H.2
Dri, P.3
Gordon, S.4
-
3
-
-
84869156976
-
Development and homeostasis of "resident" myeloid cells: The case of the microglia
-
doi:10.1002/glia.22393
-
Gomez Perdiguero, E., Schulz, C. & Geissmann, F. Development and homeostasis of "resident" myeloid cells: The case of the microglia. Glia. 61, 112-120, doi:10.1002/glia.22393 (2013).
-
(2013)
Glia.
, vol.61
, pp. 112-120
-
-
Gomez Perdiguero, E.1
Schulz, C.2
Geissmann, F.3
-
4
-
-
84875892857
-
Microglia emerge from erythromyeloid precursors via Pu.1-and Irf8-dependent pathways
-
doi:10.1038/nn.3318
-
Kierdorf, K. et al. Microglia emerge from erythromyeloid precursors via Pu.1-and Irf8-dependent pathways. Nat. Neurosci. 16, 273-280, doi:10.1038/nn.3318 (2013).
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 273-280
-
-
Kierdorf, K.1
-
5
-
-
80355143546
-
Microglial cell origin and phenotypes in health and disease
-
doi:10.1038/nri3086
-
Saijo, K. & Glass, C. K. Microglial cell origin and phenotypes in health and disease. Nature reviews. Immunology. 11,775-787, doi:10.1038/nri3086 (2011).
-
(2011)
Nature reviews. Immunology.
, vol.11
, pp. 775-787
-
-
Saijo, K.1
Glass, C.K.2
-
6
-
-
22244464662
-
ATP mediates rapid microglial response to local brain injury in vivo
-
doi:10.1038/nn1472
-
Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8, 752-758, doi:10.1038/nn1472 (2005).
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 752-758
-
-
Davalos, D.1
-
7
-
-
19744380563
-
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
-
doi:10.1126/science.1110647
-
Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 308, 1314-1318, doi:10.1126/science.1110647 (2005).
-
(2005)
Science.
, vol.308
, pp. 1314-1318
-
-
Nimmerjahn, A.1
Kirchhoff, F.2
Helmchen, F.3
-
8
-
-
0029981976
-
Cytokine and free radical production by porcine microglia
-
Hu, S. et al. Cytokine and free radical production by porcine microglia. Clin. Immunol. Immunopathol. 78, 93-96 (1996).
-
(1996)
Clin. Immunol. Immunopathol.
, vol.78
, pp. 93-96
-
-
Hu, S.1
-
9
-
-
0033844166
-
Toll-like receptors: A growing family of immune receptors that are differentially expressed and regulated by different leukocytes
-
Muzio, M., Polentarutti, N., Bosisio, D., Prahladan, M. K. & Mantovani, A. Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes. J. Leukocyte Biol. 67, 450-456 (2000).
-
(2000)
J. Leukocyte Biol.
, vol.67
, pp. 450-456
-
-
Muzio, M.1
Polentarutti, N.2
Bosisio, D.3
Prahladan, M.K.4
Mantovani, A.5
-
11
-
-
33845768784
-
Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
-
doi:10.1038/nrn2038
-
Block, M.L., Zecca, L. & Hong, J. S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69, doi:10.1038/nrn2038 (2007).
-
(2007)
Nat. Rev. Neurosci.
, vol.8
, pp. 57-69
-
-
Block, M.L.1
Zecca, L.2
Hong, J.S.3
-
12
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
-
doi:10.1038/ni.1636
-
Halle, A. et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat. Immunol. 9, 857-865, doi:10.1038/ni.1636 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 857-865
-
-
Halle, A.1
-
13
-
-
78649526394
-
Sterile inflammation: Sensing and reacting to damage
-
doi:10.1038/nri2873
-
Chen, G.Y. & Nunez, G. Sterile inflammation: sensing and reacting to damage. Nat. Rev. Immunol. 10, 826-837, doi:10.1038/nri2873 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 826-837
-
-
Chen, G.Y.1
Nunez, G.2
-
14
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
doi:10.1038/nature08938
-
Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 464, 1357-1361, doi:10.1038/nature08938 (2010).
-
(2010)
Nature.
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
-
15
-
-
75649087741
-
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6heterodimer
-
doi:10.1038/ni.1836
-
Stewart, C. R. et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6heterodimer. Nat. Immun. 11, 155-161, doi:10.1038/ni.1836 (2010).
-
(2010)
Nat. Immun.
, vol.11
, pp. 155-161
-
-
Stewart, C.R.1
-
16
-
-
84858677969
-
alpha-Synuclein Alters Toll-Like Receptor Expression
-
doi:10.3389/fnins.2011.00080
-
Beraud, D. et al. alpha-Synuclein Alters Toll-Like Receptor Expression. Front. Neurosci. 5, 80, doi:10.3389/fnins.2011.00080 (2011).
-
(2011)
Front. Neurosci.
, vol.5
, pp. 80
-
-
Beraud, D.1
-
17
-
-
0027351431
-
Cytotoxicity of microglia
-
doi:10.1002/glia.440070117
-
Banati, R.B., Gehrmann, J., Schubert, P. & Kreutzberg, G. W. Cytotoxicity of microglia. Glia. 7, 111-118, doi:10.1002/glia.440070117 (1993).
-
(1993)
Glia.
, vol.7
, pp. 111-118
-
-
Banati, R.B.1
Gehrmann, J.2
Schubert, P.3
Kreutzberg, G.W.4
-
18
-
-
0035866060
-
beta-Amyloid stimulation of microglia and monocytes results in TNF alpha-dependent expression of induciblenitric oxide synthase and neuronal apoptosis
-
Combs, C.K., Karlo, J. C., Kao, S. C. & Landreth, G. E. beta-Amyloid stimulation of microglia and monocytes results in TNF alpha-dependent expression of induciblenitric oxide synthase and neuronal apoptosis. J. Neurosci. 21, 1179-1188 (2001).
-
(2001)
J. Neurosci.
, vol.21
, pp. 1179-1188
-
-
Combs, C.K.1
Karlo, J.C.2
Kao, S.C.3
Landreth, G.E.4
-
19
-
-
33748447845
-
Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease
-
Kim, Y. S. & Joh, T. H. Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp. Mol. Med. 38, 333-347 (2006).
-
(2006)
Exp. Mol. Med.
, vol.38
, pp. 333-347
-
-
Kim, Y.S.1
Joh, T.H.2
-
21
-
-
0036321329
-
Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro
-
Nakajima, K., Tohyama, Y., Kohsaka, S. & Kurihara, T. Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro. J. Neurochem. 80, 697-705 (2002).
-
(2002)
J. Neurochem.
, vol.80
, pp. 697-705
-
-
Nakajima, K.1
Tohyama, Y.2
Kohsaka, S.3
Kurihara, T.4
-
22
-
-
33644938437
-
Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-JunN-terminal kinase (JNK)-and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia
-
doi:10.1016/j.brainres.2005.12.043
-
Uesugi, M., Nakajima, K., Tohyama, Y., Kohsaka, S. & Kurihara, T. Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-JunN-terminal kinase (JNK)-and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia. Brain Res. 1073-1074, 48-59, doi:10.1016/j.brainres.2005.12.043 (2006).
-
(2006)
Brain Res.
, vol.1073-1074
, pp. 48-59
-
-
Uesugi, M.1
Nakajima, K.2
Tohyama, Y.3
Kohsaka, S.4
Kurihara, T.5
-
23
-
-
84874654334
-
Microglial Activation and Antioxidant Responses Induced by the Parkinson's Disease Protein alpha-Synuclein
-
doi:10.1007/s11481-012-9401-0
-
Beraud, D. et al. Microglial Activation and Antioxidant Responses Induced by the Parkinson's Disease Protein alpha-Synuclein. J. Neuroimmun. Pharmacol. 8, 94-117, doi:10.1007/s11481-012-9401-0 (2013).
-
(2013)
J. Neuroimmun. Pharmacol.
, vol.8
, pp. 94-117
-
-
Beraud, D.1
-
24
-
-
51449099473
-
Synuclein activates microglia in a model of Parkinson's disease
-
doi:10.1016/j.neurobiolaging.2007.04.006
-
Su, X. et al. Synuclein activates microglia in a model of Parkinson's disease. Neurobiol. Aging. 29, 1690-1701, doi:10.1016/j.neurobiolaging.2007.04.006 (2008).
-
(2008)
Neurobiol. Aging.
, vol.29
, pp. 1690-1701
-
-
Su, X.1
-
25
-
-
0031985513
-
Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
-
Minghetti, L. & Levi, G. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog. Neurobiol. 54, 99-125 (1998).
-
(1998)
Prog. Neurobiol.
, vol.54
, pp. 99-125
-
-
Minghetti, L.1
Levi, G.2
-
26
-
-
0034052904
-
Glial cells and Parkinson's disease
-
Hirsch, E.C. Glial cells and Parkinson's disease. J. Neurol. 247 Suppl 2, II58-62 (2000).
-
(2000)
J. Neurol.
, vol.247
, Issue.SUPPL. 2
-
-
Hirsch, E.C.1
-
27
-
-
0036272473
-
Role of nitric oxide in inflammation-mediated neurodegeneration
-
Liu, B. et al. Role of nitric oxide in inflammation-mediated neurodegeneration. Ann. NY Acad. Sci. 962, 318-331 (2002).
-
(2002)
Ann. NY Acad. Sci.
, vol.962
, pp. 318-331
-
-
Liu, B.1
-
28
-
-
65649099379
-
Modulation of microglialinnate immunity in Alzheimer's disease by activation of peroxisome proliferator-activated receptor gamma
-
Shie, F.S., Nivison, M., Hsu, P. C. & Montine, T. J. Modulation of microglialinnate immunity in Alzheimer's disease by activation of peroxisome proliferator-activated receptor gamma. Curr. Med. Chem. 16, 643-651 (2009).
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 643-651
-
-
Shie, F.S.1
Nivison, M.2
Hsu, P.C.3
Montine, T.J.4
-
29
-
-
34547380204
-
Neuroinflammation in Alzheimer's disease and Parkinson's disease: Are microglia pathogenic in either disorder?
-
doi:10.1016/S0074-7742(07)82012-5
-
Rogers, J., Mastroeni, D., Leonard, B., Joyce, J. & Grover, A. Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? Int. Rev. Neurobiol. 82, 235-246, doi:10.1016/S0074-7742(07)82012-5 (2007).
-
(2007)
Int. Rev. Neurobiol.
, vol.82
, pp. 235-246
-
-
Rogers, J.1
Mastroeni, D.2
Leonard, B.3
Joyce, J.4
Grover, A.5
-
30
-
-
34248673126
-
Isolation of murinemicroglial cells for RNA analysis or flow cytometry
-
doi:10.1038/nprot.2006.327
-
Cardona, A. E., Huang, D., Sasse, M. E. & Ransohoff, R. M. Isolation of murinemicroglial cells for RNA analysis or flow cytometry. Nat. Protoc. 1, 1947-1951, doi:10.1038/nprot.2006.327 (2006).
-
(2006)
Nat. Protoc.
, vol.1
, pp. 1947-1951
-
-
Cardona, A.E.1
Huang, D.2
Sasse, M.E.3
Ransohoff, R.M.4
-
31
-
-
0029002659
-
Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigenpresentation to myelin basic protein-reactive CD4+ T cells compared
-
Ford, A.L., Goodsall, A. L., Hickey, W. F. & Sedgwick, J. D. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigenpresentation to myelin basic protein-reactive CD4+ T cells compared. J. Immunol. 154, 4309-4321 (1995).
-
(1995)
J. Immunol.
, vol.154
, pp. 4309-4321
-
-
Ford, A.L.1
Goodsall, A.L.2
Hickey, W.F.3
Sedgwick, J.D.4
-
32
-
-
0030591586
-
Tissue digestion with dispase substantially reduces lymphocyte and macrophage cell-surface antigen expression
-
Ford, A.L., Foulcher, E., Goodsall, A. L. & Sedgwick, J. D. Tissue digestion with dispase substantially reduces lymphocyte and macrophage cell-surface antigen expression. J. Immunol. Methods. 194, 71-75 (1996).
-
(1996)
J. Immunol. Methods.
, vol.194
, pp. 71-75
-
-
Ford, A.L.1
Foulcher, E.2
Goodsall, A.L.3
Sedgwick, J.D.4
-
33
-
-
80355125448
-
Isolation of brain and spinal cord mononuclear cells using percoll gradients
-
doi:10.3791/2348
-
Pino, P.A. & Cardona, A. E. Isolation of brain and spinal cord mononuclear cells using percoll gradients. J. Vis. Exp. doi:10.3791/2348 (2011).
-
(2011)
J. Vis. Exp.
-
-
Pino, P.A.1
Cardona, A.E.2
-
34
-
-
84868256937
-
Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation
-
doi:10.3791/4097
-
Veremeyko, T., Starossom, S. C., Weiner, H. L. & Ponomarev, E. D. Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. J. Vis. Exp. doi:10.3791/4097 (2012).
-
(2012)
J. Vis. Exp.
-
-
Veremeyko, T.1
Starossom, S.C.2
Weiner, H.L.3
Ponomarev, E.D.4
-
35
-
-
70349917814
-
Mutant alpha-synuclein overexpression mediates early proinflammatory activity
-
doi:10.1007/s12640-009-9053-x
-
Su, X., Federoff, H. J. & Maguire-Zeiss, K. A. Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox. Res. 16, 238-254, doi:10.1007/s12640-009-9053-x (2009).
-
(2009)
Neurotox. Res.
, vol.16
, pp. 238-254
-
-
Su, X.1
Federoff, H.J.2
Maguire-Zeiss, K.A.3
-
36
-
-
0034028817
-
Analysis of fractalkine receptorCX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
-
Jung, S. et al. Analysis of fractalkine receptorCX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol.20, 4106-4114 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 4106-4114
-
-
Jung, S.1
-
37
-
-
0030723388
-
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
-
Imai, T. et al. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell.91,521-530 (1997).
-
(1997)
Cell.
, vol.91
, pp. 521-530
-
-
Imai, T.1
-
38
-
-
33745573660
-
Control of microglial neurotoxicity by the fractalkine receptor
-
doi:10.1038/nn1715
-
Cardona, A. E. et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat. Neurosci. 9, 917-924, doi:10.1038/nn1715 (2006).
-
(2006)
Nat. Neurosci.
, vol.9
, pp. 917-924
-
-
Cardona, A.E.1
-
39
-
-
0033044951
-
Reactive microgliosis
-
Streit, W.J., Walter, S. A. & Pennell, N. A. Reactive microgliosis. Prog. Neurobiol. 57, 563-581 (1999).
-
(1999)
Prog. Neurobiol.
, vol.57
, pp. 563-581
-
-
Streit, W.J.1
Walter, S.A.2
Pennell, N.A.3
-
40
-
-
33644511746
-
Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus:Immunophenotypic and functional characteristics
-
doi:10.1016/j.jneumeth.2005.06.026
-
Frank, M.G., Wieseler-Frank, J. L., Watkins, L. R. & Maier, S. F. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus:immunophenotypic and functional characteristics. J. Neurosci. Methods. 151, 121-130, doi:10.1016/j.jneumeth.2005.06.026 (2006).
-
(2006)
J. Neurosci. Methods.
, vol.151
, pp. 121-130
-
-
Frank, M.G.1
Wieseler-Frank, J.L.2
Watkins, L.R.3
Maier, S.F.4
|