Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation

Journal of Molecular Biology

Volumn 426, Issue 20, 2014, Pages 3413-3425

  Jiang, Yuanyuan ^a   Trescott, Laura ^a   Holcomb, Joshua ^a   Zhang, Xi ^b   Brunzelle, Joseph ^c   Sirinupong, Nualpun ^d   Shi, Xiaobing ^b   Yang, Zhe ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

broad substrate specificity; estrogen receptor; histone methyltransferase; SMYD protein family; X ray crystallography

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; HISTONE LYSINE METHYLTRANSFERASE; ESTROGEN RECEPTOR ALPHA, HUMAN; ETHYLENE GLYCOL; LYSINE; PROTEIN BINDING; SMYD2 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; HISTONE METHYLATION; HORMONAL REGULATION; HUMAN; HYDROGEN BOND; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; METHYLATION; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; ETHYLENE GLYCOL; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; LYSINE; METHYLATION; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84907576553     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.02.019     Document Type: Article

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