Epigenetics meets estrogen receptor: Regulation of estrogen receptor by direct lysine methylation

Endocrine-Related Cancer

Volumn 16, Issue 2, 2009, Pages 319-323

  Zhou, Qun ^a   Shaw, Patrick G ^b,c   Davidson, Nancy E ^b,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; HISTONE METHYLTRANSFERASE; LYSINE; PROTEIN P53; HISTONE LYSINE METHYLTRANSFERASE;

ACETYLATION; ARTICLE; BREAST CANCER; CELL GROWTH; CELLULAR DISTRIBUTION; ENZYME PHOSPHORYLATION; EPIGENETICS; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE SILENCING; GENE TARGETING; HORMONE RESPONSE; HUMAN; MISSENSE MUTATION; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; UBIQUITINATION; GENETIC EPIGENESIS; METABOLISM; METHYLATION; PHYSIOLOGY; REVIEW;

EPIGENESIS, GENETIC; ESTROGEN RECEPTOR ALPHA; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; LYSINE; METHYLATION;

EID: 67650489217     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-08-0305     Document Type: Article

References (29)

1. Ali S, Metzger D, Bornert JM & Chambon P 1993 Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region. The EMBO Journal 12 1153-1160.
2. Berry NB, Fan M & Nephew KP 2008 Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. Molecular Endocrinology 22 1535-1551.
3. Chuikov S, Kurash JK, Wilson JR, Xiao B, Justin N, Ivanov GS, McKinney K, Tempst P, Prives C, Gamblin SJ, Barlev NA & Reinberg D 2004 Regulation of p53 activity through lysine methylation. Nature 432 353-360.
4. Conway K, Parrish E, Edmiston SN, Tolbert D, Tse CK, Geradts J, Livasy CA, Singh H, Newman B & Millikan RC 2005 The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study. Breast Cancer Research 7 871-880.
5. Couture JF, Collazo E, Hauk G & Trievel RC 2006 Structural basis for the methylation site specificity of SET7/9. Nature Structural and Molecular Biology 13 140-146.
6. Cui Y, Zhang M, Pestell R, Curran EM, Welshons WV & Fuqua SA 2004 Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity. Cancer Research 64 9199-9208.
7. Davies MP, O'Neill PA, Innes H & Sibson DR 2005 Hypersensitive K303R oestrogen receptor-alpha variant not found in invasive carcinomas. Breast Cancer Research 7 113-118.
8. Fuqua SA, Wiltschke C, Zhang QX, Borg A, Castles CG, Friedrichs WE, Hopp T, Hilsenbeck S, Mohsin S, O'Connell P & Allred DC 2000 A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesions. Cancer Research 60 4026-4029.
9. Huq MD, Tsai NP, Khan SA & Wei LN 2007 Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function. Molecular & Cellular Proteomics 6 677-688.
10. Jenuwein T, Laible G, Dorn R & Reuter G 1998 SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cellular and Molecular Life Sciences 54 80-93.
11. Kim MY, Woo EM, Chong YT, Homenko DR & Kraus WL 2006 Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. Molecular Endocrinology 20 1479-1493.
12. Kouskouti A, Scheer E, Staub A, Tora L & Talianidis I 2004 Gene-specific modulation of TAF10 function by SET9-mediated methylation. Molecular Cell 14 175-182.
13. Leader JE, Wang C, Popov VM, Fu M & Pestell RG 2006 Epigenetics and the estrogen receptor. Annals of the New York Academy of Sciences 1089 73-87.
14. Macaluso M, Montanari M, Noto PB, Gregorio V, Bronner C & Giordano A 2007 Epigenetic modulation of estrogen receptor-alpha by pRb family proteins: a novel mechanism in breast cancer. Cancer Research 67 7731-7737.
15. Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P & Reinberg D 2002 Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes & Development 16 479-489.
16. Noma K, Allis CD & Grewal SI 2001 Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science 293 1150-1155.
17. Ottaviano YL, Issa JP, Parl FF, Smith HS, Baylin SB & Davidson NE 1994 Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Research 54 2552-2555.
18. Pedram A, Razandi M,Wallace DC & Levin ER 2006 Functional estrogen receptors in the mitochondria of breast cancer cells. Molecular Biology of the Cell 7 2125-2137.
19. Rastelli F & Crispino S 2008 Factors predictive of response to hormone therapy in breast cancer. Tumori 94 370-383.
20. Sentis S, Le Romancer M, Bianchin C, Rostan MC & Corbo L 2005 Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity. Molecular Endocrinology 19 2671-2684.
21. Sharma D, Saxena NK, Davidson NE & Vertino PM 2006 Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Research 66 6370-6378.
22. Sims RJ, Nishioka K & Reinberg D 2003 Histone lysine methylation: a signature for chromatin function. Trends in Genetics 19 629-639.
23. Strahl BD & Allis CD 2000 The language of covalent histone modifications. Nature 403 41-45.
24. Subramanian K, Jia D, Kapoor-Vazirani P, Powell DR, Collins RE, Sharma D, Peng J, Cheng X & Vertino PM 2008 Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Molecular Cell 30 336-347.
25. Tokunaga E, Kimura Y & Maehara Y 2004 No hypersensitive estrogen receptor-alpha mutation (K303R) in Japanese breast carcinomas. Breast Cancer Research and Treatment 84 289-292.
26. Wang C, Fu M, Angeletti RH, Siconolfi-Baez L, Reutens AT, Albanese C, Lisanti MP, Katzenellenbogen BS, Kato S & Hopp T 2001a Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity. The Journal of Biological Chemistry 276 18375-18383.
27. Wang H, Cao R, Xia L, Erdjument-Bromage H, Borchers C, Tempst P & Zhang Y 2001b Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Molecular Cell 8 1207-1217.
28. Yager JD & Davidson NE 2006 Estrogen carcinogenesis in breast cancer. The New England Journal of Medicine 354 270-282.
29. Zhang Z, Maier B, Santen RJ & Song RX 2002 Membrane association of estrogen receptor alpha mediates estrogen effect on MAPK activation. Biochemical and Biophysical Research Communications 294 926-933.