SCOPUS 정보 검색 플랫폼

Volumn 22, Issue 19, 2014, Pages 5290-5297

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors

(9) Li, Xiao a Lu, Xueyi a Chen, Wenmin a Liu, Huiqing a Zhan, Peng a Pannecouque, Christophe b Balzarini, Jan b De Clercq, Erik b Liu, Xinyong a

a SHANDONG UNIVERSITY (China)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

Antiviral activity; Drug design; HIV; Molecular modeling; NNRTIs; Pyrimidine; SAR; SCR

Indexed keywords

1 N (2 BROMO 4 SULFONAMIDEPHENYL) 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZOATE; 2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO] N (2 NITROPHENYL)ACETAMIDE; 3 CHLORO 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZOIC ACID; 3 CHLORO N HYDROXY 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZAMIDE; 3 CHLORO N METHOXY 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZAMIDE; 4 [4 [[5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]BENZOIC ACID; 4 [[1 (2 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLTHIO] 5 (NAPHTHALEN 1 YL)PYRIMIDINE; 4 [[1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLTHIO] 5 (NAPHTHALEN 1 YL)PYRIMIDINE; 6 CHLORO 5 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]PICOLINIC ACID; ACETANILIDE DERIVATIVE; ARYLAZINYLTHIOACETANILIDE DERIVATIVE; DELAVIRDINE; EFAVIRENZ; ETHYL 2 [3 CHLORO 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZAMIDO]ACETATE; ETHYL 2 [3 CHLORO 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZAMIDO]PROPANOATE; ETHYL 3 BROMO 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZOATE; ETHYL 3 CHLORO 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZOATE; METHYL 3 BROMO 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZOATE; METHYL 3 CHLORO 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO]BENZOATE; METHYL 4 [2 [5 (NAPHTHALEN 1 YL)PYRIMIDIN 4 YLTHIO]ACETAMIDO] 3 NITROBENZOATE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIMIDINYLTHIOACETANILIDE DERIVATIVE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PYRIMIDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; EC50; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; SYNTHESIS; VIRUS REPLICATION;

ACETANILIDES; ANTI-HIV AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HIV-1; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84907543301 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.08.001 Document Type: Article

Times cited : (13)

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