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Bioorganic and Medicinal Chemistry

Volumn 20, Issue 8, 2012, Pages 2739-2746

Aglycone-focused randomization of 2-difluoromethylphenyl-type sialoside suicide substrates for neuraminidases

(3) Kai, Hirokazu a Hinou, Hiroshi a Nishimura, Shin Ichiro a

a HOKKAIDO UNIVERSITY (Japan)

Author keywords

Aglycone; Focused library; Mechanism based inhibitor; Neuraminidase; Suicide substrate

Indexed keywords

2 (1,3 DITHIAN 2 YL) 4 NITROPHENOL; 2 DIFLUOROMETHYL 4 AZIDOPHENYL 5 ACETOAMIDE 3,5 DIDEOXY DEXTRO GLYCERO ALPHA GALACTO NON 2 ULOPYRANOSIDONIC ACID; 2 DIFLUOROMETHYLPHENYL; 4 [3 (2,2 DICHLOROACETAMIDO)PHENYL] 1H 1,2,3 TRIAZOL 1 YL 2 (DIFLUOROMETHYL)PHENYL 5 ACETOAMIDO 3,5 DIDEOXY DEXTRO GLYCERO ALPHA GALACTO NON 2 ULOPYRANOSIDONIC ACID; 4 [[2 METHOXY 5 (TRIFLUOROMETHYL)PYRIDIN 3 YLCARBAMOYLOXY]METHYL] 1H 1,2,3 TRIAZOL 1 YL 2 (DIFLUOROMETHYL)PHENYL 5 ACETOAMIDO 3,5 DIDEOXY DEXTRO GLYCERO ALPHA GALACTO NON 2 ULOPYRANOSIDONIC ACID; 5 AZIDOSALICYLALDEHYDE; AGLYCONE; METHYL [2 DIFLUOROMETHYL 4 AZIDOPHENYL 4,7,8,9 TETRA O ACETYL 5 ACETAMIDO 3,5 DIDEOXY DEXTRO GLYCERO ALPHA GALACTO NON 2 ULOPYRANOSIDE]ONATE; METHYL [4 AZIDO 2 FORMYLPHENYL 5 ACETAMIDO 4,7,8,9 TETRA O ACETYL 3,5 DIDEOXY DEXTRO GLYCERO ALPHA GALACTO NON 2 ULOPYRANOSIDE]ONATE; OSELTAMIVIR; SIALIDASE INHIBITOR; SIALOSIDE; UNCLASSIFIED DRUG; VIRUS SIALIDASE; ZANAMIVIR;

AQUEOUS SOLUTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLICK CHEMISTRY; CONTROLLED STUDY; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; VIBRIO CHOLERAE;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLYCOSIDES; HUMANS; MOLECULAR STRUCTURE; NEURAMINIDASE; SIALIC ACIDS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VIBRIO CHOLERAE;

VIBRIO CHOLERAE;

EID: 84859429130 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.02.001 Document Type: Article

Times cited : (20)

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