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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7302-7305

The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold

(9) Bonn, Peter a Brink, D Mikael a Fägerhag, Jonas a Jurva, Ulrik a Robb, Graeme R b Schnecke, Volker a Svensson Henriksson, Anette a Waring, Michael J b Westerlund, Christer a

a ASTRAZENECA R AND D (Sweden)

b ASTRAZENECA (United Kingdom)

Author keywords

Enzyme activators; Glucokinase; Pyrazolopyrimidine

Indexed keywords

DRUG METABOLITE; ENZYME ACTIVATOR; GLUCOKINASE; GLUCOKINASE ACTIVATOR; PYRAZOLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STABILITY; ENANTIOMER; HIGH THROUGHPUT SCREENING; HUMAN; HYDROLYSIS; IC 50; LIGAND BINDING; LIPOPHILICITY; MOLECULAR DOCKING; MOLECULAR INTERACTION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME ACTIVATION; GLUCOKINASE; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870247310 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.10.090 Document Type: Article

Times cited : (19)

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