Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway

Neuroscience

Volumn 278, Issue , 2014, Pages 31-39

  Lee, J H ^a   Jeong, J K ^a   Park, S Y ^a  

^a Chonbuk National University   (South Korea)

Author keywords

AMPK; Autophagy; Neurotoxicity; Prion; Sulforaphane

Indexed keywords

AUTOPHAGY PROTEIN 5; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 II PROTEIN; PRION PROTEIN; PRION PROTEIN[106-126]; PROTEIN P62; SULFORAPHANE; UNCLASSIFIED DRUG; ATG5 PROTEIN, HUMAN; ISOTHIOCYANIC ACID DERIVATIVE; MICROTUBULE ASSOCIATED PROTEIN; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; PRION; PRION PROTEIN (106-126); SULFORAFAN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; NERVE CELL; NEUROBLASTOMA; PRION; TOXICITY; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; HUMANS; ISOTHIOCYANATES; MICROTUBULE-ASSOCIATED PROTEINS; NEUROBLASTOMA; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PRIONS; SIGNAL TRANSDUCTION;

EID: 84907500316     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.07.072     Document Type: Article

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