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Volumn 9, Issue 9, 2014, Pages

CD4+ T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; GRANZYME B; KI 67 ANTIGEN; LATENCY ASSOCIATED PEPTIDE; PERFORIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR 2; CCR5 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; GRANZYME; GZMB PROTEIN, HUMAN; LATENCY-ASSOCIATED PROPEPTIDE, TGF-BETA; PEPTIDE; PROTEIN PRECURSOR; TUMOR MARKER;

EID: 84907499311     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108554     Document Type: Article
Times cited : (31)

References (34)
  • 1
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi S (2004) Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22: 531-562.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 2
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    • Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, et al. (2005) Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341.
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3    Dooley, J.L.4    Farr, A.G.5
  • 3
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 4
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • Bluestone JA, Abbas AK (2003) Natural versus adaptive regulatory T cells. Nat Rev Immunol 3: 253-257.
    • (2003) Nat Rev Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 5
    • 33846913897 scopus 로고    scopus 로고
    • Natural regulatory T cells and de novo-induced regulatory T cells contribute independendy to tumor-specific tolerance
    • Zhou G, Levitsky HI (2007) Natural regulatory T cells and de novo-induced regulatory T cells contribute independendy to tumor-specific tolerance. J Immunol 178: 2155-2162.
    • (2007) J Immunol , vol.178 , pp. 2155-2162
    • Zhou, G.1    Levitsky, H.I.2
  • 6
    • 0038044861 scopus 로고    scopus 로고
    • IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell function
    • Chen ZM, O'Shaughnessy MJ, Gramaglia I, Panoskaltsis-Mortari A, Murphy WJ, et al. (2003) IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell function. Blood 101: 5076-5083.
    • (2003) Blood , vol.101 , pp. 5076-5083
    • Chen, Z.M.1    O'Shaughnessy, M.J.2    Gramaglia, I.3    Panoskaltsis-Mortari, A.4    Murphy, W.J.5
  • 7
    • 10744221289 scopus 로고    scopus 로고
    • Developmental stage, phenotype, and migration distinguish naive- and effector/ memory-like CD4+ regulatory T cells
    • Huehn J, Siegmund K, Lehmann JC, Siewert C, Haubold U, et al. (2004) Developmental stage, phenotype, and migration distinguish naive- and effector/ memory-like CD4+ regulatory T cells. J Exp Med 199: 303-313.
    • (2004) J Exp Med , vol.199 , pp. 303-313
    • Huehn, J.1    Siegmund, K.2    Lehmann, J.C.3    Siewert, C.4    Haubold, U.5
  • 8
    • 14944346738 scopus 로고    scopus 로고
    • Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    • Ermann J, Hoffmann P, Edinger M, Dutt S, Blankenberg FG, et al. (2005) Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 105: 2220-2226.
    • (2005) Blood , vol.105 , pp. 2220-2226
    • Ermann, J.1    Hoffmann, P.2    Edinger, M.3    Dutt, S.4    Blankenberg, F.G.5
  • 9
    • 52649147984 scopus 로고    scopus 로고
    • In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease
    • Zhao D, Zhang C, Yi T, Lin CL, Todorov I, et al. (2008) In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease. Blood 112: 2129-2138.
    • (2008) Blood , vol.112 , pp. 2129-2138
    • Zhao, D.1    Zhang, C.2    Yi, T.3    Lin, C.L.4    Todorov, I.5
  • 10
    • 77951881004 scopus 로고    scopus 로고
    • Enrichment of CCR6+Foxp3+ regulatory T cells in the tumor mass correlates with impaired CD8+ T cell function and poor prognosis of breast cancer
    • Xu L, Xu W, Qiu S, Xiong S (2010) Enrichment of CCR6+Foxp3+ regulatory T cells in the tumor mass correlates with impaired CD8+ T cell function and poor prognosis of breast cancer. Clin Immunol 135: 466-475.
    • (2010) Clin Immunol , vol.135 , pp. 466-475
    • Xu, L.1    Xu, W.2    Qiu, S.3    Xiong, S.4
  • 11
    • 27644497249 scopus 로고    scopus 로고
    • Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease
    • Wysocki CA, Jiang Q, Panoskaltsis-Mortari A, Taylor PA, McKinnon KP, et al. (2005) Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood 106: 3300-3307.
    • (2005) Blood , vol.106 , pp. 3300-3307
    • Wysocki, C.A.1    Jiang, Q.2    Panoskaltsis-Mortari, A.3    Taylor, P.A.4    McKinnon, K.P.5
  • 12
    • 77952376596 scopus 로고    scopus 로고
    • Effector/ memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity
    • Lin YC, Chang LY, Huang CT, Peng HM, Dutta A, et al. (2009) Effector/ memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity. J Immunol 182: 6095-6104.
    • (2009) J Immunol , vol.182 , pp. 6095-6104
    • Lin, Y.C.1    Chang, L.Y.2    Huang, C.T.3    Peng, H.M.4    Dutta, A.5
  • 13
    • 0036791004 scopus 로고    scopus 로고
    • Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    • Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, et al. (2002) Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Nad Acad Sci USA 99: 13031-13036.
    • (2002) Proc Nad Acad Sci USA , vol.99 , pp. 13031-13036
    • Lehmann, J.1    Huehn, J.2    De La Rosa, M.3    Maszyna, F.4    Kretschmer, U.5
  • 14
    • 84926109500 scopus 로고    scopus 로고
    • TNF-alpha: An activator of CD4+FoxP3+ TNFR2+ regulatory T cells
    • Chen X, Oppenheim JJ (2010) TNF-alpha: an activator of CD4+FoxP3+ TNFR2+ regulatory T cells. Gurr Dir Autoimmun 11: 119-134.
    • (2010) Gurr Dir Autoimmun , vol.11 , pp. 119-134
    • Chen, X.1    Oppenheim, J.J.2
  • 15
    • 84863626453 scopus 로고    scopus 로고
    • The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells
    • Chang LY, Lin YG, Kang CW, Hsu CY, Chu YY, et al. (2012) The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells. J Immunol 189: 567-574.
    • (2012) J Immunol , vol.189 , pp. 567-574
    • Chang, L.Y.1    Lin, Y.G.2    Kang, C.W.3    Hsu, C.Y.4    Chu, Y.Y.5
  • 16
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, et al. (2009) Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30: 899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3    Shima, T.4    Wing, K.5
  • 17
    • 84872932778 scopus 로고    scopus 로고
    • Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer
    • Lin YG, Mahalingam J, Chiang JM, Su PJ, Chu YY, et al. (2013) Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer. Int J Cancer 132: 1341-1350.
    • (2013) Int J Cancer , vol.132 , pp. 1341-1350
    • Lin, Y.G.1    Mahalingam, J.2    Chiang, J.M.3    Su, P.J.4    Chu, Y.Y.5
  • 18
    • 58149187111 scopus 로고    scopus 로고
    • CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice
    • Wei HX, Chuang YH, Li B, Wei H, Sun R, et al. (2008) CD4+ CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. J Immunol 181: 7221-7229.
    • (2008) J Immunol , vol.181 , pp. 7221-7229
    • Wei, H.X.1    Chuang, Y.H.2    Li, B.3    Wei, H.4    Sun, R.5
  • 19
    • 77955012740 scopus 로고    scopus 로고
    • IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which joindy restrain CD4+CD25- cell activation
    • Wang G, Khattar M, Guo Z, Miyahara Y, Linkes SP, et al. (2010) IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which joindy restrain CD4+CD25- cell activation. Immunol Lett 132: 61-68.
    • (2010) Immunol Lett , vol.132 , pp. 61-68
    • Wang, G.1    Khattar, M.2    Guo, Z.3    Miyahara, Y.4    Linkes, S.P.5
  • 20
    • 9244261022 scopus 로고    scopus 로고
    • Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function
    • Tang Q. Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, et al. (2004) Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol 34: 2996-3005.
    • (2004) Eur J Immunol , vol.34 , pp. 2996-3005
    • Tang, Q.1    Boden, E.K.2    Henriksen, K.J.3    Bour-Jordan, H.4    Bi, M.5
  • 21
    • 44849133287 scopus 로고    scopus 로고
    • The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function
    • Shevach EM, Tran DQ, Davidson TS, Andersson J (2008) The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function. Eur J Immunol 38: 915-917.
    • (2008) Eur J Immunol , vol.38 , pp. 915-917
    • Shevach, E.M.1    Tran, D.Q.2    Davidson, T.S.3    Andersson, J.4
  • 22
    • 0038363534 scopus 로고    scopus 로고
    • IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    • Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, et al. (2003) IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 33: 1205-1214.
    • (2003) Eur J Immunol , vol.33 , pp. 1205-1214
    • Jutel, M.1    Akdis, M.2    Budak, F.3    Aebischer-Casaulta, C.4    Wrzyszcz, M.5
  • 23
    • 0027466618 scopus 로고
    • Transforming growth factor-beta: Latent forms, binding proteins and receptors
    • Miyazono K, Ichijo H, Heldin CH (1993) Transforming growth factor-beta: latent forms, binding proteins and receptors. Growth Factors 8: 11 -22.
    • (1993) Growth Factors , vol.8 , pp. 11-22
    • Miyazono, K.1    Ichijo, H.2    Heldin, C.H.3
  • 24
    • 1642577126 scopus 로고    scopus 로고
    • TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    • Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, et al. (2004) TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 172: 834-842.
    • (2004) J Immunol , vol.172 , pp. 834-842
    • Nakamura, K.1    Kitani, A.2    Fuss, I.3    Pedersen, A.4    Harada, N.5
  • 25
    • 78649650472 scopus 로고    scopus 로고
    • TGF-beta induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction
    • Oida T, Weiner HL (2010) TGF-beta induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction. PLoS One 5: e15523.
    • (2010) PLoS One , vol.5 , pp. e15523
    • Oida, T.1    Weiner, H.L.2
  • 26
    • 33645225611 scopus 로고    scopus 로고
    • Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells
    • Zhang X, Reddy J, Ochi H, Frenkel D, Kuchroo VK, et al. (2006) Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells. Int Immunol 18: 495-503.
    • (2006) Int Immunol , vol.18 , pp. 495-503
    • Zhang, X.1    Reddy, J.2    Ochi, H.3    Frenkel, D.4    Kuchroo, V.K.5
  • 27
    • 83755173097 scopus 로고    scopus 로고
    • Inducible CD4+LAP+ Foxp3- regulatory T cells suppress allergic inflammation
    • Duan W, So T, Mehta AK, Choi H, Croft M (2011) Inducible CD4+LAP+ Foxp3- regulatory T cells suppress allergic inflammation. J Immunol 187: 6499 -6507.
    • (2011) J Immunol , vol.187 , pp. 6499-6507
    • Duan, W.1    So, T.2    Mehta, A.K.3    Choi, H.4    Croft, M.5
  • 28
    • 77953116038 scopus 로고    scopus 로고
    • Cutting edge: Human latency-associated peptide+ T cells: A novel regulatory T cell subset
    • Gandhi R, Farez MF, Wang Y, Kozoriz D, Quintana FJ, et al. (2010) Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset. J Immunol 184: 4620-4624.
    • (2010) J Immunol , vol.184 , pp. 4620-4624
    • Gandhi, R.1    Farez, M.F.2    Wang, Y.3    Kozoriz, D.4    Quintana, F.J.5
  • 29
    • 84866916324 scopus 로고    scopus 로고
    • LAP+CD4+ T cells are suppressors accumulated in the tumor sites and associated with the progression of colorectal cancer
    • Mahalingam J, Lin YC, Chiang JM, Su PJ, Fang JH, et al. (2012) LAP+CD4+ T Cells Are Suppressors Accumulated in the Tumor Sites and Associated with the Progression of Colorectal Cancer. Clin Cancer Res 18: 5224-5233.
    • (2012) Clin Cancer Res , vol.18 , pp. 5224-5233
    • Mahalingam, J.1    Lin, Y.C.2    Chiang, J.M.3    Su, P.J.4    Fang, J.H.5
  • 30
    • 47249119632 scopus 로고    scopus 로고
    • Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis
    • Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL (2008) Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol 180: 7327-7337.
    • (2008) J Immunol , vol.180 , pp. 7327-7337
    • Chen, M.L.1    Yan, B.S.2    Bando, Y.3    Kuchroo, V.K.4    Weiner, H.L.5
  • 31
  • 32
    • 51049101255 scopus 로고    scopus 로고
    • CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner
    • Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, et al. (2008) CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med 205: 1975-1981.
    • (2008) J Exp Med , vol.205 , pp. 1975-1981
    • Andersson, J.1    Tran, D.Q.2    Pesu, M.3    Davidson, T.S.4    Ramsey, H.5
  • 33
    • 65549168545 scopus 로고    scopus 로고
    • Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD 121a/CD 121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures
    • Tran DQ, Andersson J, Hardwick D, Bebris L, Illei GG, et al. (2009) Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD 121a/CD 121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures. Blood 113: 5125-5133.
    • (2009) Blood , vol.113 , pp. 5125-5133
    • Tran, D.Q.1    Andersson, J.2    Hardwick, D.3    Bebris, L.4    Illei, G.G.5
  • 34
    • 84865712860 scopus 로고    scopus 로고
    • Identification of human regulatory T cells in the setting of T-cell activation and anti-CTLA-4 immunotherapy on the basis of expression of latency-associated peptide
    • Sun J, Tang DN, Fu T, Sharma P (2012) Identification of human regulatory T cells in the setting of T-cell activation and anti-CTLA-4 immunotherapy on the basis of expression of latency-associated peptide. Cancer Discov 2: 122-130.
    • (2012) Cancer Discov , vol.2 , pp. 122-130
    • Sun, J.1    Tang, D.N.2    Fu, T.3    Sharma, P.4


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