메뉴 건너뛰기




Volumn 132, Issue 6, 2013, Pages 1341-1350

Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer

Author keywords

colorectal cancer; effector memory T cells; regulatory T cell; tumor infiltrating lymphocyte

Indexed keywords

CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; L SELECTIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

EID: 84872932778     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27784     Document Type: Article
Times cited : (91)

References (50)
  • 1
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • DOI 10.1038/ni1178
    • Sakaguchi S,. Naturally arising Foxp3-expressing CD25 CD4 regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6: 345-52. (Pubitemid 41716771)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 345-352
    • Sakaguchi, S.1
  • 2
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
    • DOI 10.1016/j.immuni.2005.01.016
    • Fontenot J, Rasmussen J, Williams L, et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005; 22: 329-41. (Pubitemid 40387475)
    • (2005) Immunity , vol.22 , Issue.3 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3    Dooley, J.L.4    Farr, A.G.5    Rudensky, A.Y.6
  • 3
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W,. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006; 6: 295-307.
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 5
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β
    • Nadkarni S, Mauri C, Ehrenstein M,. Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. J Exp Med 2007; 204: 33.
    • (2007) J Exp Med , vol.204 , pp. 33
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.3
  • 6
    • 34248194231 scopus 로고    scopus 로고
    • Tregs and rethinking cancer immunotherapy
    • DOI 10.1172/JCI31202
    • Curiel T,. Tregs and rethinking cancer immunotherapy. J Clin Invest 2007; 117: 1167-74. (Pubitemid 46718401)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.5 , pp. 1167-1174
    • Curiel, T.J.1
  • 7
    • 31644440642 scopus 로고    scopus 로고
    • + T cell cytotoxicity and cancer
    • DOI 10.1016/j.semcancer.2005.11.006, PII S1044579X05000763, Regulating the Regulators or How ti Elicit an Immune Response
    • reg on tumor specific CD8+ T cell cytotoxicity and cancer. Semin Cancer Biol 2006; 16: 124-36. (Pubitemid 43172061)
    • (2006) Seminars in Cancer Biology , vol.16 , Issue.2 , pp. 124-136
    • Khazaie, K.1    Von Boehmer, H.2
  • 8
    • 65549112641 scopus 로고    scopus 로고
    • Dynamic behavior and function of Foxp3+ regulatory T cells in tumor bearing host
    • Qin F,. Dynamic behavior and function of Foxp3+ regulatory T cells in tumor bearing host. Cell Mol Immunol 2009; 6: 3-13.
    • (2009) Cell Mol Immunol , vol.6 , pp. 3-13
    • Qin, F.1
  • 10
    • 27744477593 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in the peripheral blood of patients with breast cancer and non-small cell lung cancer
    • Okita R, Saeki T, Takashima S, et al. CD4+CD25+ regulatory T cells in the peripheral blood of patients with breast cancer and non-small cell lung cancer. Oncol Rep 2005; 14: 1269-73.
    • (2005) Oncol Rep , vol.14 , pp. 1269-1273
    • Okita, R.1    Saeki, T.2    Takashima, S.3
  • 11
    • 34047141055 scopus 로고    scopus 로고
    • Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients
    • Ling KL, Pratap SE, Bates GJ, et al. Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients. Cancer Immun 2007; 7: 7.
    • (2007) Cancer Immun , vol.7 , pp. 7
    • Ling, K.L.1    Pratap, S.E.2    Bates, G.J.3
  • 12
    • 38349075755 scopus 로고    scopus 로고
    • The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with thalidomide
    • Giannopoulos K, Schmitt M, Własiuk P, et al. The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with thalidomide. Leukemia 2008; 22: 222.
    • (2008) Leukemia , vol.22 , pp. 222
    • Giannopoulos, K.1    Schmitt, M.2    Własiuk, P.3
  • 13
    • 67349193581 scopus 로고    scopus 로고
    • Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism
    • Cambien B, Karimdjee B, Richard-Fiardo P, et al. Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. Br J Cancer 2009; 100: 1755-64.
    • (2009) Br J Cancer , vol.100 , pp. 1755-1764
    • Cambien, B.1    Karimdjee, B.2    Richard-Fiardo, P.3
  • 14
    • 53349153303 scopus 로고    scopus 로고
    • Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    • Clark R, Huang S, Murphy G, et al. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med 2008; 205: 2221.
    • (2008) J Exp Med , vol.205 , pp. 2221
    • Clark, R.1    Huang, S.2    Murphy, G.3
  • 16
    • 25844517914 scopus 로고    scopus 로고
    • Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+ CD25+ CD4+ regulatory T cells
    • Ko K, Yamazaki S, Nakamura K, et al. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+ CD25+ CD4+ regulatory T cells. J Exp Med 2005; 202: 885.
    • (2005) J Exp Med , vol.202 , pp. 885
    • Ko, K.1    Yamazaki, S.2    Nakamura, K.3
  • 17
    • 70749146017 scopus 로고    scopus 로고
    • Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model
    • Hong H, Gu Y, Zhang H, et al. Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model. Clin Exp Immunol 2010; 159: 93-9.
    • (2010) Clin Exp Immunol , vol.159 , pp. 93-99
    • Hong, H.1    Gu, Y.2    Zhang, H.3
  • 18
    • 54949139152 scopus 로고    scopus 로고
    • CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer
    • Clarke SL, Betts GJ, Plant A, et al. CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. PLoS ONE 2006; 1: e129.
    • (2006) PLoS ONE , vol.1
    • Clarke, S.L.1    Betts, G.J.2    Plant, A.3
  • 19
    • 84863717093 scopus 로고    scopus 로고
    • Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer
    • Betts G, Jones E, Junaid S, et al. Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut 2011.
    • (2011) Gut
    • Betts, G.1    Jones, E.2    Junaid, S.3
  • 21
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X, Bailey-Bucktrout SL, Jeker LT, et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009; 10: 1000-7.
    • (2009) Nat Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3
  • 22
    • 0036791004 scopus 로고    scopus 로고
    • Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    • Lehmann J, Huehn J, de la Rosa M, et al. Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Natl Acad Sci USA 2002; 99: 13031-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13031-13036
    • Lehmann, J.1    Huehn, J.2    De La Rosa, M.3
  • 24
    • 34249806715 scopus 로고    scopus 로고
    • + regulatory T cells participate in the control of immune responses
    • Stephens GL, Andersson J, Shevach EM,. Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses. J Immunol 2007; 178: 6901-11. (Pubitemid 46847416)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 6901-6911
    • Stephens, G.L.1    Andersson, J.2    Shevach, E.M.3
  • 26
    • 26844468978 scopus 로고    scopus 로고
    • Essential role for CD103 in the T cell-mediated regulation of experimental colitis
    • Annacker O, Coombes J, Malmstrom V, et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med 2005; 202: 1051.
    • (2005) J Exp Med , vol.202 , pp. 1051
    • Annacker, O.1    Coombes, J.2    Malmstrom, V.3
  • 27
    • 52649147984 scopus 로고    scopus 로고
    • In vivo-Activated CD103+ CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease
    • Zhao D, Zhang C, Yi T, et al. In vivo-Activated CD103+ CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease. Blood 2008; 112: 2129.
    • (2008) Blood , vol.112 , pp. 2129
    • Zhao, D.1    Zhang, C.2    Yi, T.3
  • 28
    • 77952376596 scopus 로고    scopus 로고
    • Effector/memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity
    • Lin YC, Chang LY, Huang CT, et al. Effector/memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity. J Immunol 2009; 182: 6095-104.
    • (2009) J Immunol , vol.182 , pp. 6095-6104
    • Lin, Y.C.1    Chang, L.Y.2    Huang, C.T.3
  • 29
    • 79959712939 scopus 로고    scopus 로고
    • CD103 is a hallmark of tumor-infiltrating regulatory T cells
    • Anz D, Mueller W, Golic M, et al. CD103 is a hallmark of tumor-infiltrating regulatory T cells. Int J Cancer 2011; 129: 2417-26.
    • (2011) Int J Cancer , vol.129 , pp. 2417-2426
    • Anz, D.1    Mueller, W.2    Golic, M.3
  • 30
    • 27644497249 scopus 로고    scopus 로고
    • Critical role for CCR5 in the function of donor CD4+ CD25+ regulatory T cells during acute graft-versus-host disease
    • Wysocki C, Jiang Q, Panoskaltsis-Mortari A, et al. Critical role for CCR5 in the function of donor CD4+ CD25+ regulatory T cells during acute graft-versus-host disease. Blood 2005; 106: 3300.
    • (2005) Blood , vol.106 , pp. 3300
    • Wysocki, C.1    Jiang, Q.2    Panoskaltsis-Mortari, A.3
  • 32
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009; 30: 899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 33
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R,. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer 2009; 9: 798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 34
    • 79959902280 scopus 로고    scopus 로고
    • The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells
    • Chen X, Oppenheim JJ,. The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells. Immunology 2011; 133: 426-33.
    • (2011) Immunology , vol.133 , pp. 426-433
    • Chen, X.1    Oppenheim, J.J.2
  • 35
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • Rudd CE, Taylor A, Schneider H,. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 2009; 229: 12-26.
    • (2009) Immunol Rev , vol.229 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 36
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-Associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-Associated antigen 4. J Exp Med 2000; 192: 303-10.
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 37
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I, Coukos G, Dranoff G,. Cancer immunotherapy comes of age. Nature 2011; 480: 480-9.
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 39
    • 63249123219 scopus 로고    scopus 로고
    • CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression
    • Shen LS, Wang J, Shen DF, et al. CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression. Clin Immunol 2009; 131: 109-18.
    • (2009) Clin Immunol , vol.131 , pp. 109-118
    • Shen, L.S.1    Wang, J.2    Shen, D.F.3
  • 40
    • 70349100093 scopus 로고    scopus 로고
    • Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer
    • Lemoine FM, Cherai M, Giverne C, et al. Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer. Int J Oncol 2009; 35: 569-81.
    • (2009) Int J Oncol , vol.35 , pp. 569-581
    • Lemoine, F.M.1    Cherai, M.2    Giverne, C.3
  • 41
    • 58249089749 scopus 로고    scopus 로고
    • Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    • Salama P, Phillips M, Grieu F, et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009; 27: 186-92.
    • (2009) J Clin Oncol , vol.27 , pp. 186-192
    • Salama, P.1    Phillips, M.2    Grieu, F.3
  • 42
    • 77954959667 scopus 로고    scopus 로고
    • Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy
    • Correale P, Rotundo MS, Del Vecchio MT, et al. Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy. J Immunother 2010; 33: 435-41.
    • (2010) J Immunother , vol.33 , pp. 435-441
    • Correale, P.1    Rotundo, M.S.2    Del Vecchio, M.T.3
  • 43
    • 83555174415 scopus 로고    scopus 로고
    • Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells
    • Tao H, Mimura Y, Aoe K, et al. Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells. Lung Cancer 2012; 75: 95-101.
    • (2012) Lung Cancer , vol.75 , pp. 95-101
    • Tao, H.1    Mimura, Y.2    Aoe, K.3
  • 44
    • 77952778924 scopus 로고    scopus 로고
    • Tumor-Associated lymphocytes and increased FoxP3+ regulatory T cell frequency correlate with more aggressive papillary thyroid cancer
    • French JD, Weber ZJ, Fretwell DL, et al. Tumor-Associated lymphocytes and increased FoxP3+ regulatory T cell frequency correlate with more aggressive papillary thyroid cancer. J Clin Endocrinol Metab 2010; 95: 2325-33.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2325-2333
    • French, J.D.1    Weber, Z.J.2    Fretwell, D.L.3
  • 45
    • 70349423483 scopus 로고    scopus 로고
    • Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    • Sinicrope FA, Rego RL, Ansell SM, et al. Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology 2009; 137: 1270-9.
    • (2009) Gastroenterology , vol.137 , pp. 1270-1279
    • Sinicrope, F.A.1    Rego, R.L.2    Ansell, S.M.3
  • 46
    • 45949099261 scopus 로고    scopus 로고
    • Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: A caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells
    • Chen GY, Chen C, Wang L, et al. Cutting edge: broad expression of the FoxP3 locus in epithelial cells: A caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells. J Immunol 2008; 180: 5163-6.
    • (2008) J Immunol , vol.180 , pp. 5163-5166
    • Chen, G.Y.1    Chen, C.2    Wang, L.3
  • 47
    • 70350537020 scopus 로고    scopus 로고
    • Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas
    • Attig S, Hennenlotter J, Pawelec G, et al. Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas. Cancer Res 2009; 69: 8412-9.
    • (2009) Cancer Res , vol.69 , pp. 8412-8419
    • Attig, S.1    Hennenlotter, J.2    Pawelec, G.3
  • 48
    • 80053252362 scopus 로고    scopus 로고
    • Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells
    • Chen X, Oppenheim JJ,. Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells. Int Immunopharmacol 2011; 11: 1489-96.
    • (2011) Int Immunopharmacol , vol.11 , pp. 1489-1496
    • Chen, X.1    Oppenheim, J.J.2
  • 49
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008; 322: 271.
    • (2008) Science , vol.322 , pp. 271
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 50
    • 79955040909 scopus 로고    scopus 로고
    • IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer
    • Kryczek I, Wu K, Zhao E, et al. IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer. J Immunol 2011; 186: 4388-95.
    • (2011) J Immunol , vol.186 , pp. 4388-4395
    • Kryczek, I.1    Wu, K.2    Zhao, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.