메뉴 건너뛰기




Volumn 9, Issue 10, 2014, Pages

Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxPSites

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR PAX6; CRE RECOMBINASE; INTEGRASE;

EID: 84907494908     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109193     Document Type: Article
Times cited : (28)

References (69)
  • 1
    • 0034312313 scopus 로고    scopus 로고
    • Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    • Ashery-Padan R, Marquardt T, Zhou XL, Gruss P (2000). Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev 14: 2701-2711.
    • (2000) Genes Dev , vol.14 , pp. 2701-2711
    • Ashery-Padan, R.1    Marquardt, T.2    Zhou, X.L.3    Gruss, P.4
  • 2
    • 32944454587 scopus 로고    scopus 로고
    • Targeted deletion of AP-2 alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma
    • Dwivedi DJ, Pontoriero GF, Ashery-Padan R, Sullivan S, Williams T, et al. (2005). Targeted deletion of AP-2 alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma. Invest Ophthalmol Vis Sci 46: 3623-3630.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 3623-3630
    • Dwivedi, D.J.1    Pontoriero, G.F.2    Ashery-Padan, R.3    Sullivan, S.4    Williams, T.5
  • 3
    • 19544377184 scopus 로고    scopus 로고
    • Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation
    • Garcia CM, Yu K, Zhao HT, Ashery-Padan R, Ornitz DM, et al. (2005). Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation. Dev Dyn 233: 516-527.
    • (2005) Dev Dyn , vol.233 , pp. 516-527
    • Garcia, C.M.1    Yu, K.2    Zhao, H.T.3    Ashery-Padan, R.4    Ornitz, D.M.5
  • 4
    • 25844490866 scopus 로고    scopus 로고
    • The duality of β-catenin function: A requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm
    • Smith AN, Miller LAD, Song N, Taketo MM, Lang RA (2005). The duality of β-catenin function: A requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol 285: 477-489.
    • (2005) Dev Biol , vol.285 , pp. 477-489
    • Smith, A.N.1    Miller, L.A.D.2    Song, N.3    Taketo, M.M.4    Lang, R.A.5
  • 5
    • 33751109710 scopus 로고    scopus 로고
    • Six3 activation of pax6 expression is essential for mammalian lens induction and specification
    • Liu W, Lagutin OV, Mende M, Streit A, Oliver G (2006). Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J 25: 5383-5395.
    • (2006) EMBO J , vol.25 , pp. 5383-5395
    • Liu, W.1    Lagutin, O.V.2    Mende, M.3    Streit, A.4    Oliver, G.5
  • 6
    • 33845790551 scopus 로고    scopus 로고
    • Conditional deletion of the mouse klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells
    • Swamynathan SK, Katz JP, Kaestner KH, Ashery-Padan R, Crawford MA, et al. (2007). Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol 27: 182-194.
    • (2007) Mol Cell Biol , vol.27 , pp. 182-194
    • Swamynathan, S.K.1    Katz, J.P.2    Kaestner, K.H.3    Ashery-Padan, R.4    Crawford, M.A.5
  • 8
    • 80955181154 scopus 로고    scopus 로고
    • Conditional disruption of mouse klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells
    • Kenchegowda D, Swamynathan S, Gupta D, Wan H, Whitsett J, et al. (2011). Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells. Dev Biol 356: 5-18.
    • (2011) Dev Biol , vol.356 , pp. 5-18
    • Kenchegowda, D.1    Swamynathan, S.2    Gupta, D.3    Wan, H.4    Whitsett, J.5
  • 9
    • 84866427428 scopus 로고    scopus 로고
    • Critical role of klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneas
    • Kenchegowda D, Harvey SAK, Swamynathan S, Lathrop KL, Swamynathan SK (2012). Critical role of Klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneas. PLoS One 7: e0044771.
    • (2012) PLoS One , vol.7 , pp. e0044771
    • Kenchegowda, D.1    Harvey, S.A.K.2    Swamynathan, S.3    Lathrop, K.L.4    Swamynathan, S.K.5
  • 10
    • 77951250927 scopus 로고    scopus 로고
    • Disruption of mouse corneal epithelial differentiation by conditional inactivation of pnn
    • Joo JH, Kim YH, Dunn NW, Sugrue SP (2010). Disruption of mouse corneal epithelial differentiation by conditional inactivation of Pnn. Invest Ophthalmol Vis Sci 51: 1927-1934.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 1927-1934
    • Joo, J.H.1    Kim, Y.H.2    Dunn, N.W.3    Sugrue, S.P.4
  • 11
  • 12
    • 80755153156 scopus 로고    scopus 로고
    • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival
    • Maddala R, Chauhan BK, Walker C, Zheng Y, Robinson ML, et al. (2011). Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol 360: 30-43.
    • (2011) Dev Biol , vol.360 , pp. 30-43
    • Maddala, R.1    Chauhan, B.K.2    Walker, C.3    Zheng, Y.4    Robinson, M.L.5
  • 13
    • 79957627442 scopus 로고    scopus 로고
    • Genetic epistasis between heparan sulfate and FGF-ras signaling controls lens development
    • Qu X, Hertzler K, Pan Y, Grobe K, Robinson ML, et al. (2011). Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development. Dev Biol 355: 12-20.
    • (2011) Dev Biol , vol.355 , pp. 12-20
    • Qu, X.1    Hertzler, K.2    Pan, Y.3    Grobe, K.4    Robinson, M.L.5
  • 14
    • 84871856385 scopus 로고    scopus 로고
    • Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death
    • Cammas L, Wolfe J, Choi S-Y, Dedhar S, Beggs H (2012). Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death. Invest Ophthalmol Vis Sci 53: 3067-3081.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 3067-3081
    • Cammas, L.1    Wolfe, J.2    Choi, S.-Y.3    Dedhar, S.4    Beggs, H.5
  • 15
    • 61849146995 scopus 로고    scopus 로고
    • The function of VEGF-A in lens development: Formation of the hyaloid capillary network and protection against transient nuclear cataracts
    • Garcia CM, Shui Y-B, Kamath M, DeVillar J, Johnson RS, et al. (2009). The function of VEGF-A in lens development: Formation of the hyaloid capillary network and protection against transient nuclear cataracts. Exp Eye Res 88: 270-276.
    • (2009) Exp Eye Res , vol.88 , pp. 270-276
    • Garcia, C.M.1    Shui, Y.-B.2    Kamath, M.3    DeVillar, J.4    Johnson, R.S.5
  • 16
    • 53349120212 scopus 로고    scopus 로고
    • Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis
    • Chen Y, Doughman Y-q, Gu S, Jarrell A, Aota S-i, et al. (2008). Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 135: 2939-2948.
    • (2008) Development , vol.135 , pp. 2939-2948
    • Chen, Y.1    Doughman, Y.-Q.2    Gu, S.3    Jarrell, A.4    Aota, S.-I.5
  • 17
    • 70249135216 scopus 로고    scopus 로고
    • Conditional deletion of cited2 results in defective corneal epithelial morphogenesis and maintenance
    • Chen Y, Carlson EC, Chen ZY, Hamik A, Jain MK, et al. (2009). Conditional deletion of Cited2 results in defective corneal epithelial morphogenesis and maintenance. Dev Biol 334: 243-252.
    • (2009) Dev Biol , vol.334 , pp. 243-252
    • Chen, Y.1    Carlson, E.C.2    Chen, Z.Y.3    Hamik, A.4    Jain, M.K.5
  • 18
    • 84863314020 scopus 로고    scopus 로고
    • Deletion of HIF-1α partially rescues the abnormal hyaloid vascular system in cited2 conditional knockout mouse eyes
    • Huang T-Q, Wang Y, Ebrahem Q, Chen Y, Cheng C, et al. (2012). Deletion of HIF-1α partially rescues the abnormal hyaloid vascular system in Cited2 conditional knockout mouse eyes. Mol Vis 18: 1260-1270.
    • (2012) Mol Vis , vol.18 , pp. 1260-1270
    • Huang, T.-Q.1    Wang, Y.2    Ebrahem, Q.3    Chen, Y.4    Cheng, C.5
  • 20
    • 0038010517 scopus 로고    scopus 로고
    • Requirement for pax6 in corneal morphogenesis: A role in adhesion
    • Davis J, Duncan MK, Robison WG, Piatigorsky J (2003). Requirement for Pax6 in corneal morphogenesis: a role in adhesion. J Cell Sci 116: 2157-2167.
    • (2003) J Cell Sci , vol.116 , pp. 2157-2167
    • Davis, J.1    Duncan, M.K.2    Robison, W.G.3    Piatigorsky, J.4
  • 25
    • 0034656096 scopus 로고    scopus 로고
    • The lens organizes the anterior segment: Specification of neural crest cell differentiation in the avian eye
    • Beebe DC, Coats JM (2000). The lens organizes the anterior segment: Specification of neural crest cell differentiation in the avian eye. Dev Biol 220: 424-431.
    • (2000) Dev Biol , vol.220 , pp. 424-431
    • Beebe, D.C.1    Coats, J.M.2
  • 26
    • 0035859899 scopus 로고    scopus 로고
    • Primary defects in the lens underlie complex anterior segment abnormalities of the pax6 heterozygous eye
    • Collinson JM, Quinn JC, Buchanan MA, Kaufman MH, Wedden SE, et al. (2001). Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye. Proc Natl Acad Sci USA 98: 9688-9693.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9688-9693
    • Collinson, J.M.1    Quinn, J.C.2    Buchanan, M.A.3    Kaufman, M.H.4    Wedden, S.E.5
  • 27
    • 80054892346 scopus 로고    scopus 로고
    • Paracrine pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube
    • Di Lullo E, Haton C, Le Poupon C, Volovitch M, Joliot A, et al. (2011). Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development 138: 4991-5001.
    • (2011) Development , vol.138 , pp. 4991-5001
    • Di Lullo, E.1    Haton, C.2    Le Poupon, C.3    Volovitch, M.4    Joliot, A.5
  • 29
    • 77955387940 scopus 로고    scopus 로고
    • Reduced expression of pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma
    • Kroeber M, Davis N, Holzmann S, Kritzenberger M, Shelah-Goraly M, et al. (2010). Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma. Hum Mol Genet 19: 3332-3342.
    • (2010) Hum Mol Genet , vol.19 , pp. 3332-3342
    • Kroeber, M.1    Davis, N.2    Holzmann, S.3    Kritzenberger, M.4    Shelah-Goraly, M.5
  • 30
    • 84907503283 scopus 로고    scopus 로고
    • Homozygosity for the le-cre transgene is associated with microphthalmia and cataracts in the absence of other engineered genetic changes
    • Robinson ML, Walton NA, Wallace LM, Yang Y (2005). Homozygosity for the Le-Cre transgene is associated with microphthalmia and cataracts in the absence of other engineered genetic changes. Invest Ophthalmol Vis Sci 46 Supplement S: Meeting Abstract 1885.
    • (2005) Invest Ophthalmol Vis Sci , vol.46
    • Robinson, M.L.1    Walton, N.A.2    Wallace, L.M.3    Yang, Y.4
  • 31
    • 67650976711 scopus 로고    scopus 로고
    • Normal ventral telencephalic expression of pax6 is required for normal development of thalamocortical axons in embryonic mice
    • Simpson TI, Pratt T, Mason JO, Price DJ (2009) Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice. Neural Dev 4, 19.
    • (2009) Neural Dev , vol.4 , pp. 19
    • Simpson, T.I.1    Pratt, T.2    Mason, J.O.3    Price, D.J.4
  • 32
    • 0029979219 scopus 로고    scopus 로고
    • Multiple functions for pax6 in mouse eye and nasal development
    • Quinn JC, West JD, Hill RE (1996). Multiple functions for Pax6 in mouse eye and nasal development. Genes Dev 10: 435-446.
    • (1996) Genes Dev , vol.10 , pp. 435-446
    • Quinn, J.C.1    West, J.D.2    Hill, R.E.3
  • 33
    • 0030581164 scopus 로고    scopus 로고
    • Influence of pax6 gene dosage on development - Overexpression causes severe eye abnormalities
    • Schedl A, Ross A, Lee M, Engelkamp D, Rashbass P, et al. (1996). Influence of Pax6 gene dosage on development - overexpression causes severe eye abnormalities. Cell 86: 71-82.
    • (1996) Cell , vol.86 , pp. 71-82
    • Schedl, A.1    Ross, A.2    Lee, M.3    Engelkamp, D.4    Rashbass, P.5
  • 35
    • 84855267423 scopus 로고    scopus 로고
    • Effects of aberrant pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis
    • Mort RL, Bentley AJ, Martin FL, Collinson JM, Douvaras P, et al. (2011) Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis PLoS One 6: e28895.
    • (2011) PLoS One , vol.6 , pp. e28895
    • Mort, R.L.1    Bentley, A.J.2    Martin, F.L.3    Collinson, J.M.4    Douvaras, P.5
  • 37
    • 0029999012 scopus 로고    scopus 로고
    • Ultrastructural, immunohistological and biochemical characterization of cultured mouse corneal epithelial cells
    • Hazlett L, Masinick S, Mezger B, Barrett R, Kurpakus M, et al. (1996). Ultrastructural, immunohistological and biochemical characterization of cultured mouse corneal epithelial cells. Ophthalmic Res 28: 50-56.
    • (1996) Ophthalmic Res , vol.28 , pp. 50-56
    • Hazlett, L.1    Masinick, S.2    Mezger, B.3    Barrett, R.4    Kurpakus, M.5
  • 38
    • 0034526271 scopus 로고    scopus 로고
    • Dosage requirement and allelic expression of PAX6 during lens placode formation
    • van Raamsdonk CD, Tilghman SM (2000). Dosage requirement and allelic expression of PAX6 during lens placode formation. Development 127: 5439-5448.
    • (2000) Development , vol.127 , pp. 5439-5448
    • Van Raamsdonk, C.D.1    Tilghman, S.M.2
  • 40
    • 34247174789 scopus 로고    scopus 로고
    • Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces
    • Yoshida S, Shimmura S, Kawakita T, Miyashita H, Den S, et al. (2006). Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Invest Ophthalmol Vis Sci 47: 4780-4786.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 4780-4786
    • Yoshida, S.1    Shimmura, S.2    Kawakita, T.3    Miyashita, H.4    Den, S.5
  • 42
    • 43449103925 scopus 로고    scopus 로고
    • PAX6 dosage effects on corneal development, growth and wound healing
    • Dorà N, Ou J, Kucerova R, Parisi I, West JD, et al. (2008). PAX6 dosage effects on corneal development, growth and wound healing. Dev Dyn 237: 1295-1306.
    • (2008) Dev Dyn , vol.237 , pp. 1295-1306
    • Dorà, N.1    Ou, J.2    Kucerova, R.3    Parisi, I.4    West, J.D.5
  • 43
    • 0029965062 scopus 로고    scopus 로고
    • Conjunctival epithelial cells can resurface denuded cornea, but do not transdifferentiate to express cornea-specific keratin 12 following removal of limbal epithelium in mouse
    • Moyer PD, Kaufman AH, Zhang Z, Kao CWC, Spaulding AG, et al. (1996). Conjunctival epithelial cells can resurface denuded cornea, but do not transdifferentiate to express cornea-specific keratin 12 following removal of limbal epithelium in mouse. Differentiation 60: 31-38.
    • (1996) Differentiation , vol.60 , pp. 31-38
    • Moyer, P.D.1    Kaufman, A.H.2    Zhang, Z.3    Kao, C.W.C.4    Spaulding, A.G.5
  • 45
    • 0033104951 scopus 로고    scopus 로고
    • Corneal epithelium-specific mouse keratin K12 promoter
    • Liu JJ, Kao WWY, Wilson SE (1999). Corneal epithelium-specific mouse keratin K12 promoter. Exp Eye Res 68: 295-301.
    • (1999) Exp Eye Res , vol.68 , pp. 295-301
    • Liu, J.J.1    Kao, W.W.Y.2    Wilson, S.E.3
  • 46
    • 0031736865 scopus 로고    scopus 로고
    • Identification of the cornea-specific keratin 12 promoter by in vivo particle-mediated gene transfer
    • Shiraishi A, Converse RL, Liu CY, Zhou F, Kao CWC, et al. (1998). Identification of the cornea-specific keratin 12 promoter by in vivo particle-mediated gene transfer. Invest Ophthalmol Vis Sci 39: 2554-2561.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 2554-2561
    • Shiraishi, A.1    Converse, R.L.2    Liu, C.Y.3    Zhou, F.4    Kao, C.W.C.5
  • 47
    • 33746158128 scopus 로고    scopus 로고
    • Abnormal migration and distribution of neural crest cells in pax6 heterozygous mutant eye, a model for human eye diseases
    • Kanakubo S, Nomura T, Yamamura KI, Miyazaki JI, Tamai M, et al. (2006). Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases. Genes Cells 11: 919-933.
    • (2006) Genes Cells , vol.11 , pp. 919-933
    • Kanakubo, S.1    Nomura, T.2    Yamamura, K.I.3    Miyazaki, J.I.4    Tamai, M.5
  • 48
  • 49
    • 78951475584 scopus 로고    scopus 로고
    • Good planning and serendipity: Exploiting the cre/lox system in the testis
    • Smith L (2011). Good planning and serendipity: exploiting the Cre/Lox system in the testis. Reproduction 141: 151-161.
    • (2011) Reproduction , vol.141 , pp. 151-161
    • Smith, L.1
  • 50
    • 84879868603 scopus 로고    scopus 로고
    • Metabolic pitfalls of CNS cre-based technology
    • Harno E, Cottrell EC, White A (2013). Metabolic pitfalls of CNS Cre-based technology. Cell Metab 18: 21-28.
    • (2013) Cell Metab , vol.18 , pp. 21-28
    • Harno, E.1    Cottrell, E.C.2    White, A.3
  • 51
    • 32344441180 scopus 로고    scopus 로고
    • Synapsin I cre transgene expression produces germline recombination in male mice progeny
    • Rempe D, Vangeison G, Hamilton J, Li Y, Jepson M, et al. (2006). Synapsin I cre transgene expression produces germline recombination in male mice progeny. Genesis 44: 44-49.
    • (2006) Genesis , vol.44 , pp. 44-49
    • Rempe, D.1    Vangeison, G.2    Hamilton, J.3    Li, Y.4    Jepson, M.5
  • 52
    • 41549155539 scopus 로고    scopus 로고
    • Promiscuous recombination of LoxP alleles during gametogenesis in cornea cre driver mice
    • Weng DY, Zhang Y, Hayashi Y, Kuan C-Y, Liu C-Y, et al. (2008). Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice. Mol Vis 14: 562-571.
    • (2008) Mol Vis , vol.14 , pp. 562-571
    • Weng, D.Y.1    Zhang, Y.2    Hayashi, Y.3    Kuan, C.-Y.4    Liu, C.-Y.5
  • 53
    • 0342732880 scopus 로고    scopus 로고
    • Targeting of cre to the foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures
    • Hebert JM, McConnell SK (2000). Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol 222: 296-306.
    • (2000) Dev Biol , vol.222 , pp. 296-306
    • Hebert, J.M.1    McConnell, S.K.2
  • 54
    • 0343415768 scopus 로고    scopus 로고
    • Mammalian genomes contain active recombinase recognition sites
    • Thyagarajan B, Guimaraes MJ, Groth AC, Calos MP (2000). Mammalian genomes contain active recombinase recognition sites. Gene 244: 47-54.
    • (2000) Gene , vol.244 , pp. 47-54
    • Thyagarajan, B.1    Guimaraes, M.J.2    Groth, A.C.3    Calos, M.P.4
  • 55
    • 34247130822 scopus 로고    scopus 로고
    • Cryptic loxP sites in mammalian genomes: Genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques
    • Semprini S, Troup TJ, Kotelevtseva N, King K, Davis JRE, et al. (2007). Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques. Nucleic Acids Res 35: 1402-1410.
    • (2007) Nucleic Acids Res , vol.35 , pp. 1402-1410
    • Semprini, S.1    Troup, T.J.2    Kotelevtseva, N.3    King, K.4    Davis, J.R.E.5
  • 56
    • 0034888424 scopus 로고    scopus 로고
    • Self-excising retroviral vectors encoding the cre recombinase overcome cre-mediated cellular toxicity
    • Silver DP, Livingston DM (2001). Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell 8: 233-243.
    • (2001) Mol Cell , vol.8 , pp. 233-243
    • Silver, D.P.1    Livingston, D.M.2
  • 58
    • 21744436924 scopus 로고    scopus 로고
    • Practical range of effective dose for cre recombinase-expressing recombinant adenovirus without cell toxicity in mammalian cells
    • Baba Y, Nakano M, Yamada Y, Saito I, Kanegae Y (2005). Practical range of effective dose for Cre recombinase-expressing recombinant adenovirus without cell toxicity in mammalian cells. Microbiol Immunol 49: 559-570.
    • (2005) Microbiol Immunol , vol.49 , pp. 559-570
    • Baba, Y.1    Nakano, M.2    Yamada, Y.3    Saito, I.4    Kanegae, Y.5
  • 59
    • 84896884418 scopus 로고    scopus 로고
    • Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites
    • Janbandhu V, Moik D, Fässler R (2014). Cre recombinase induces DNA damage and tetraploidy in the absence of LoxP sites. Cell Cycle 13: 462-470.
    • (2014) Cell Cycle , vol.13 , pp. 462-470
    • Janbandhu, V.1    Moik, D.2    Fässler, R.3
  • 61
    • 0035949704 scopus 로고    scopus 로고
    • Delivery of the cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo
    • Pfeifer A, Brandon EP, Kootstra N, Gage FH, Verma IM (2001). Delivery of the Cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo. Proc Natl Acad Sci USA 98: 11450-11455.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11450-11455
    • Pfeifer, A.1    Brandon, E.P.2    Kootstra, N.3    Gage, F.H.4    Verma, I.M.5
  • 62
    • 33748705967 scopus 로고    scopus 로고
    • High levels of cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly
    • Forni PE, Scuoppo C, Imayoshi I, Taulli R, Dastru W, et al. (2006). High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci 26: 9593-9602.
    • (2006) J Neurosci , vol.26 , pp. 9593-9602
    • Forni, P.E.1    Scuoppo, C.2    Imayoshi, I.3    Taulli, R.4    Dastru, W.5
  • 63
    • 38549123928 scopus 로고    scopus 로고
    • Cre activity causes widespread apoptosis and lethal anemia during embryonic development
    • Naiche LA, Papaioannou VE (2007). Cre activity causes widespread apoptosis and lethal anemia during embryonic development. Genesis 45: 768-775.
    • (2007) Genesis , vol.45 , pp. 768-775
    • Naiche, L.A.1    Papaioannou, V.E.2
  • 64
    • 84860239954 scopus 로고    scopus 로고
    • Evidence for baseline retinal pigment epithelium pathology in the trp1-cre mouse
    • Thanos A, Morizane Y, Murakami Y, Giani A, Mantopoulos D, et al. (2012). Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol 180: 1917-1927.
    • (2012) Am J Pathol , vol.180 , pp. 1917-1927
    • Thanos, A.1    Morizane, Y.2    Murakami, Y.3    Giani, A.4    Mantopoulos, D.5
  • 65
    • 33646384957 scopus 로고    scopus 로고
    • RIP-cre revisited, evidence for impairments of pancreatic beta-cell function
    • Lee JY, Ristow M, Lin XY, White MF, Magnuson MA, et al. (2006). RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem 281: 2649-2653.
    • (2006) J Biol Chem , vol.281 , pp. 2649-2653
    • Lee, J.Y.1    Ristow, M.2    Lin, X.Y.3    White, M.F.4    Magnuson, M.A.5
  • 66
    • 33744548947 scopus 로고    scopus 로고
    • Dilated cardiomyopathy resulting from high-level myocardial expression of crerecombinase
    • Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, et al. (2006). Dilated cardiomyopathy resulting from high-level myocardial expression of Crerecombinase. J Card Fail 12: 392-398.
    • (2006) J Card Fail , vol.12 , pp. 392-398
    • Buerger, A.1    Rozhitskaya, O.2    Sherwood, M.C.3    Dorfman, A.L.4    Bisping, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.