메뉴 건너뛰기




Volumn 63, Issue 10, 2014, Pages 3483-3496

Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; ANGIOTENSINOGEN; CATALASE; GLUCOSE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 14; OLTIPRAZ; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; TRIGONELLINE; NFE2L2 PROTEIN, MOUSE; PYRAZINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

EID: 84907486499     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1830     Document Type: Article
Times cited : (42)

References (48)
  • 1
    • 0024943180 scopus 로고
    • Molecular biology and pathophysiology of the intrarenal renin-angiotensin system
    • Dzau VJ, Ingelfinger JR. Molecular biology and pathophysiology of the intrarenal renin-angiotensin system. J Hypertens Suppl 1989;7:S3-S8
    • (1989) J Hypertens Suppl , vol.7 , pp. S3-S8
    • Dzau, V.J.1    Ingelfinger, J.R.2
  • 2
    • 0032913340 scopus 로고    scopus 로고
    • Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells
    • Zhang SL, Filep JG, Hohman TC, Tang SS, Ingelfinger JR, Chan JS. Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells. Kidney Int 1999;55:454-464
    • (1999) Kidney Int , vol.55 , pp. 454-464
    • Zhang, S.L.1    Filep, J.G.2    Hohman, T.C.3    Tang, S.S.4    Ingelfinger, J.R.5    Chan, J.S.6
  • 3
    • 0034522676 scopus 로고    scopus 로고
    • High levels of glucose stimulate angiotensinogen gene expression via the P38 mitogenactivated protein kinase pathway in rat kidney proximal tubular cells
    • Zhang SL, Tang SS, Chen X, Filep JG, Ingelfinger JR, Chan JS. High levels of glucose stimulate angiotensinogen gene expression via the P38 mitogenactivated protein kinase pathway in rat kidney proximal tubular cells. Endocrinology 2000;141:4637-4646
    • (2000) Endocrinology , vol.141 , pp. 4637-4646
    • Zhang, S.L.1    Tang, S.S.2    Chen, X.3    Filep, J.G.4    Ingelfinger, J.R.5    Chan, J.S.6
  • 4
    • 0036324130 scopus 로고    scopus 로고
    • High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells
    • Hsieh TJ, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Chan JS. High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. Endocrinology 2002;143:2975-2985
    • (2002) Endocrinology , vol.143 , pp. 2975-2985
    • Hsieh, T.J.1    Zhang, S.L.2    Filep, J.G.3    Tang, S.S.4    Ingelfinger, J.R.5    Chan, J.S.6
  • 5
    • 0141785482 scopus 로고    scopus 로고
    • High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells
    • Hsieh TJ, Fustier P, Zhang SL, et al. High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells. Endocrinology 2003; 144:4338-4349
    • (2003) Endocrinology , vol.144 , pp. 4338-4349
    • Hsieh, T.J.1    Fustier, P.2    Zhang, S.L.3
  • 6
    • 33644853998 scopus 로고    scopus 로고
    • RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney
    • Sachetelli S, Liu Q, Zhang SL, et al. RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int 2006;69:1016-1023
    • (2006) Kidney Int , vol.69 , pp. 1016-1023
    • Sachetelli, S.1    Liu, Q.2    Zhang, S.L.3
  • 7
    • 39049115715 scopus 로고    scopus 로고
    • Overexpression of angiotensinogen increases tubular apoptosis in diabetes
    • Liu F, Brezniceanu ML, Wei CC, et al. Overexpression of angiotensinogen increases tubular apoptosis in diabetes. J Am Soc Nephrol 2008;19:269-280
    • (2008) J Am Soc Nephrol , vol.19 , pp. 269-280
    • Liu, F.1    Brezniceanu, M.L.2    Wei, C.C.3
  • 8
    • 84859476274 scopus 로고    scopus 로고
    • Dual RAS blockade normalizes angiotensinconverting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice
    • Lo CS, Liu F, Shi Y, et al. Dual RAS blockade normalizes angiotensinconverting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice. Am J Physiol Renal Physiol 2012;302:F840-F852
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F840-F852
    • Lo, C.S.1    Liu, F.2    Shi, Y.3
  • 9
    • 58149149793 scopus 로고    scopus 로고
    • Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension
    • Liu F, Wei CC, Wu SJ, et al. Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension. Kidney Int 2009;75:156-166
    • (2009) Kidney Int , vol.75 , pp. 156-166
    • Liu, F.1    Wei, C.C.2    Wu, S.J.3
  • 10
    • 77956927516 scopus 로고    scopus 로고
    • Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice
    • Godin N, Liu F, Lau GJ, et al. Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice. Kidney Int 2010;77: 1086-1097
    • (2010) Kidney Int , vol.77 , pp. 1086-1097
    • Godin, N.1    Liu, F.2    Lau, G.J.3
  • 11
    • 34247501789 scopus 로고    scopus 로고
    • Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice
    • Brezniceanu ML, Liu F, Wei CC, et al. Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice. Kidney Int 2007;71 : 912-923
    • (2007) Kidney Int , vol.71 , pp. 912-923
    • Brezniceanu, M.L.1    Liu, F.2    Wei, C.C.3
  • 12
    • 40749161602 scopus 로고    scopus 로고
    • Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells
    • Brezniceanu ML, Liu F, Wei CC, et al. Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells. Diabetes 2008;57:451-459
    • (2008) Diabetes , vol.57 , pp. 451-459
    • Brezniceanu, M.L.1    Liu, F.2    Wei, C.C.3
  • 13
    • 84878662766 scopus 로고    scopus 로고
    • Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensinconverting enzyme-2 expression in Akita mice
    • Shi Y, Lo C-S, Chenier I, et al. Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensinconverting enzyme-2 expression in Akita mice. Am J Physiol Renal Physiol 2013; 304:F1335-F1346
    • (2013) Am J Physiol Renal Physiol , vol.304 , pp. F1335-F1346
    • Shi, Y.1    Lo, C.-S.2    Chenier, I.3
  • 14
    • 56249106571 scopus 로고    scopus 로고
    • Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    • Surh YJ, Kundu JK, Na HK. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 2008;74:1526-1539
    • (2008) Planta Med , vol.74 , pp. 1526-1539
    • Surh, Y.J.1    Kundu, J.K.2    Na, H.K.3
  • 15
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • Motohashi H, Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 2004;10:549-557
    • (2004) Trends Mol Med , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 16
    • 0029906134 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:Quinone oxidoreductase1 gene
    • Venugopal R, Jaiswal AK. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc Natl Acad Sci U S A 1996; 93:14960-14965
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14960-14965
    • Venugopal, R.1    Jaiswal, A.K.2
  • 17
    • 0031907377 scopus 로고    scopus 로고
    • Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells
    • Wang L, Lei C, Zhang SL, et al. Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells. Kidney Int 1998;53:287-295
    • (1998) Kidney Int , vol.53 , pp. 287-295
    • Wang, L.1    Lei, C.2    Zhang, S.L.3
  • 18
    • 0034997199 scopus 로고    scopus 로고
    • Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice
    • Ding Y, Sigmund CD. Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. Am J Physiol Renal Physiol 2001;280:F54-F60
    • (2001) Am J Physiol Renal Physiol , vol.280 , pp. F54-F60
    • Ding, Y.1    Sigmund, C.D.2
  • 19
    • 84878877698 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice
    • Abdo S, Lo CS, Chenier I, et al. Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice. Diabetologia 2013; 56:1649-1660
    • (2013) Diabetologia , vol.56 , pp. 1649-1660
    • Abdo, S.1    Lo, C.S.2    Chenier, I.3
  • 20
    • 0030451213 scopus 로고    scopus 로고
    • NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • Chan K, Lu R, Chang JC, Kan YW. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A 1996;93:13943-13948
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 21
    • 0035001166 scopus 로고    scopus 로고
    • Characterization of a putative insulinresponsive element and its binding protein(s) in rat angiotensinogen gene promoter: Regulation by glucose and insulin
    • Chen X, Zhang SL, Pang L, et al. Characterization of a putative insulinresponsive element and its binding protein(s) in rat angiotensinogen gene promoter: Regulation by glucose and insulin. Endocrinology 2001;142:2577-2585
    • (2001) Endocrinology , vol.142 , pp. 2577-2585
    • Chen, X.1    Zhang, S.L.2    Pang, L.3
  • 22
    • 24144496134 scopus 로고    scopus 로고
    • Characterization of susceptibility of inbred mouse strains to diabetic nephropathy
    • Qi Z, Fujita H, Jin J, et al. Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes 2005;54:2628-2637
    • (2005) Diabetes , vol.54 , pp. 2628-2637
    • Qi, Z.1    Fujita, H.2    Jin, J.3
  • 23
    • 77949770480 scopus 로고    scopus 로고
    • Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice
    • Aleksunes LM, Reisman SA, Yeager RL, Goedken MJ, Klaassen CD. Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. J Pharmacol Exp Ther 2010; 333:140-151
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 140-151
    • Aleksunes, L.M.1    Reisman, S.A.2    Yeager, R.L.3    Goedken, M.J.4    Klaassen, C.D.5
  • 24
    • 84885177241 scopus 로고    scopus 로고
    • Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
    • Arlt A, Sebens S, Krebs S, et al. Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene 2013;32:4825-4835
    • (2013) Oncogene , vol.32 , pp. 4825-4835
    • Arlt, A.1    Sebens, S.2    Krebs, S.3
  • 25
    • 77953518507 scopus 로고    scopus 로고
    • The NADPH oxidase subunit N0X4 is a new target gene of the hypoxia-inducible factor-1
    • Diebold I, Petry A, Hess J, Görlach A. The NADPH oxidase subunit N0X4 is a new target gene of the hypoxia-inducible factor-1. Mol Biol Cell 2010;21:2087-2096
    • (2010) Mol Biol Cell , vol.21 , pp. 2087-2096
    • Diebold, I.1    Petry, A.2    Hess, J.3    Görlach, A.4
  • 26
    • 0033035228 scopus 로고    scopus 로고
    • Rat proximal tubule cell line transformed with origin-defective SV40 DNA: Autocrine ANG II feedback
    • Ingelfinger JR, Jung F, Diamant D, et al. Rat proximal tubule cell line transformed with origin-defective SV40 DNA: Autocrine ANG II feedback. Am J Physiol 1999;276:F218-F227
    • (1999) Am J Physiol , vol.276 , pp. F218-F227
    • Ingelfinger, J.R.1    Jung, F.2    Diamant, D.3
  • 27
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7MH89 on chromosome 7 determines early-on set NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka M, Kayo T, Ikeda T, Koizumi A. A novel locus, Mody4, distal to D7MH89 on chromosome 7 determines early-on set NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 1997;46:887-894
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 28
    • 0036924179 scopus 로고    scopus 로고
    • Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse
    • Haseyama T, Fujita T, Hirasawa F, et al. Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse. Tohoku J Exp Med 2002;198:233-244
    • (2002) Tohoku J Exp Med , vol.198 , pp. 233-244
    • Haseyama, T.1    Fujita, T.2    Hirasawa, F.3
  • 31
    • 73949108178 scopus 로고    scopus 로고
    • Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes
    • Saito T, Urushihara M, Kotan i Y, Kagami S, Kobori H. Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes. Am J Med Sci 2009;338:478-480
    • (2009) Am J Med Sci , vol.338 , pp. 478-480
    • Saito, T.1    Urushihara, M.2    Kotani, Y.3    Kagami, S.4    Kobori, H.5
  • 32
    • 77954386389 scopus 로고    scopus 로고
    • Urinary angiotensinogen is correlated with blood pressure in men (Bogalusa Heart Study)
    • Kobori H, Urushihara M, Xu JH, Berenson GS, Navar LG. Urinary angiotensinogen is correlated with blood pressure in men (Bogalusa Heart Study). J Hypertens 2010;28:1422-1428
    • (2010) J Hypertens , vol.28 , pp. 1422-1428
    • Kobori, H.1    Urushihara, M.2    Xu, J.H.3    Berenson, G.S.4    Navar, L.G.5
  • 33
    • 79954426057 scopus 로고    scopus 로고
    • Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension
    • Navar LG, Prieto MC, Satou R, Kobori H. Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension. Curr Opin Pharmacol 2011; 11:180-186
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 180-186
    • Navar, L.G.1    Prieto, M.C.2    Satou, R.3    Kobori, H.4
  • 34
    • 70350787401 scopus 로고    scopus 로고
    • Total antioxidant capacity, catalase and superoxide dismutase on rats before and after diabetes
    • Celik S, Akkaya H. Total antioxidant capacity, catalase and superoxide dismutase on rats before and after diabetes. J Anim Vet Adv 2009;8:1503-1508
    • (2009) J Anim Vet Adv , vol.8 , pp. 1503-1508
    • Celik, S.1    Akkaya, H.2
  • 35
    • 67651124692 scopus 로고    scopus 로고
    • Low catalase activity in blood is associated with the diabetes caused by alloxan
    • Takemoto K, Tanaka M, Iwata H, et al. Low catalase activity in blood is associated with the diabetes caused by alloxan. Clin Chim Acta 2009;407:43-46
    • (2009) Clin Chim Acta , vol.407 , pp. 43-46
    • Takemoto, K.1    Tanaka, M.2    Iwata, H.3
  • 36
    • 79955068967 scopus 로고    scopus 로고
    • Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia
    • Ungvari Z, Bailey-Downs L, Gautam T, et al. Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol 2011;300:H1133-H1140
    • (2011) Am J Physiol Heart Circ Physiol , vol.300 , pp. H1133-H1140
    • Ungvari, Z.1    Bailey-Downs, L.2    Gautam, T.3
  • 37
    • 0036240610 scopus 로고    scopus 로고
    • Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter
    • Kwak MK, Itoh K, Yamamoto M, Kensler TW. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol 2002;22: 2883-2892
    • (2002) Mol Cell Biol , vol.22 , pp. 2883-2892
    • Kwak, M.K.1    Itoh, K.2    Yamamoto, M.3    Kensler, T.W.4
  • 39
    • 7944220437 scopus 로고    scopus 로고
    • Diallyl sulfide induces heme oxygenase-1 through MAPK pathway
    • Gong P, Hu B, Cederbaum AI. Diallyl sulfide induces heme oxygenase-1 through MAPK pathway. Arch Biochem Biophys 2004;432:252-260
    • (2004) Arch Biochem Biophys , vol.432 , pp. 252-260
    • Gong, P.1    Hu, B.2    Cederbaum, A.I.3
  • 40
    • 77949430099 scopus 로고    scopus 로고
    • P38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and downregulation of COX-2 in human bladder cancer cells
    • Shan Y, Wang X, Wang W, He C, Bao Y. p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and downregulation of COX-2 in human bladder cancer cells. Oncol Rep 2010;23:1133-1138
    • (2010) Oncol Rep , vol.23 , pp. 1133-1138
    • Shan, Y.1    Wang, X.2    Wang, W.3    He, C.4    Bao, Y.5
  • 41
    • 84879475972 scopus 로고    scopus 로고
    • Lipoxin A4-induced heme oxygenase-1 protects cardiomyocytes against hypoxia/reoxygenation injury via p38 MAPK activation and Nrf2/ARE complex
    • Chen XQ, Wu SH, Zhou Y, Tang YR. Lipoxin A4-induced heme oxygenase-1 protects cardiomyocytes against hypoxia/reoxygenation injury via p38 MAPK activation and Nrf2/ARE complex. PLoS One 2013;8:e67120
    • (2013) PLoS One , vol.8 , pp. e67120
    • Chen, X.Q.1    Wu, S.H.2    Zhou, Y.3    Tang, Y.R.4
  • 42
    • 79951853800 scopus 로고    scopus 로고
    • Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
    • Yu M, Li H, Liu Q, et al. Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell Signal 2011;23:883-892
    • (2011) Cell Signal , vol.23 , pp. 883-892
    • Yu, M.1    Li, H.2    Liu, Q.3
  • 43
    • 41949141296 scopus 로고    scopus 로고
    • NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
    • Liu GH, Qu J, Shen X. NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim Biophys Acta 2008;1783:713-727
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 713-727
    • Liu, G.H.1    Qu, J.2    Shen, X.3
  • 44
    • 78650355319 scopus 로고    scopus 로고
    • The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice
    • Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice. J Biol Chem 2010;285: 40581-40592
    • (2010) J Biol Chem , vol.285 , pp. 40581-40592
    • Saha, P.K.1    Reddy, V.T.2    Konopleva, M.3    Andreeff, M.4    Chan, L.5
  • 45
    • 84879175433 scopus 로고    scopus 로고
    • Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of type 2 diabetes and obesity
    • Chin M, Lee CY, Chuang JC, et al. Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of type 2 diabetes and obesity. Am J Physiol Renal Physiol 2013;304:F1438-F1446
    • (2013) Am J Physiol Renal Physiol , vol.304 , pp. F1438-F1446
    • Chin, M.1    Lee, C.Y.2    Chuang, J.C.3
  • 46
    • 84877930774 scopus 로고    scopus 로고
    • Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects
    • Zoja C, Corna D, Nava V, et al. Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects. Am J Physiol Renal Physiol 2013;304:F808-F819
    • (2013) Am J Physiol Renal Physiol , vol.304 , pp. F808-F819
    • Zoja, C.1    Corna, D.2    Nava, V.3
  • 47
    • 79960855656 scopus 로고    scopus 로고
    • Bardoxolone methyl and kidney function in CKD with type 2 diabetes
    • BEAM Study Investigators.
    • Pergola PE, Raskin P, Toto RD, et al.; BEAM Study Investigators. Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med 2011;365:327-336
    • (2011) N Engl J Med , vol.365 , pp. 327-336
    • Pergola, P.E.1    Raskin, P.2    Toto, R.D.3
  • 48
    • 84890946148 scopus 로고    scopus 로고
    • Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease
    • BEACON Trial Investigators.
    • de Zeeuw D, Akizawa T, Audhya P, et al.; BEACON Trial Investigators. Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. N Engl J Med 2013;369:2492-2503
    • (2013) N Engl J Med , vol.369 , pp. 2492-2503
    • De Zeeuw, D.1    Akizawa, T.2    Audhya, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.