RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney

Kidney International

Volumn 69, Issue 6, 2006, Pages 1016-1023

  Sachetelli, S ^a   Liu, Q ^a   Zhang, S L ^a   Liu, F ^a   Hsieh, T J ^a   Brezniceanu, M L ^a   Guo, D F ^a   Filep, J G ^b   Ingelfinger, J R ^c   Sigmund, C D ^d   Hamet, P ^a   Chan, J S D ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

Angiotensinogen; Hypertension; Proteinuria; Transgenic mice

Indexed keywords

ANDROGEN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSINOGEN; COMPLEMENTARY DNA; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LOSARTAN; PERINDOPRIL; TESTOSTERONE;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; HORMONE SYNTHESIS; HYPERTENSION; KIDNEY; KIDNEY DISEASE; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEINURIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK FACTOR; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANGIOTENSINOGEN; ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION REGULATION; HYPERTENSION; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY DISEASES; LOSARTAN; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PERINDOPRIL; PROTEINS; PROTEINURIA; RATS; RENIN-ANGIOTENSIN SYSTEM;

EID: 33644853998     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000210     Document Type: Article

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