Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice

Diabetologia

Volumn 56, Issue 7, 2013, Pages 1649-1660

  Abdo, S ^a   Lo, C S ^a   Chenier, I ^a   Shamsuyarova, A ^a   Filep, J G ^a   Ingelfinger, J R ^b   Zhang, S L ^a   Chan, J S D ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Akita mice; Angiotensin converting enzyme 2; Angiotensinogen; Diabetes; Heterogeneous nuclear ribonucleoprotein F; Heterogeneous nuclear ribonucleoprotein K; Hypertension; Insulin; Kidney injury

Indexed keywords

ALBUMIN; ANGIOTENSIN; ANGIOTENSIN CONVERTING ENZYME 2; BOVINE INSULIN PLUS PIG INSULIN PLUS HUMAN INSULIN; CREATININE; GLUCOSE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN F; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K; INSULIN DERIVATIVE; LINBIT; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACE2 GENE; AGT GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG IMPLANT; GENE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HNRNP F GENE; HNRNP K GENE; HYPERTENSION; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN LIKE ACTIVITY; KIDNEY HYPERTROPHY; KIDNEY INJURY; KIDNEY TUBULE CELL; MALE; MICROALBUMINURIA; MOUSE; NONHUMAN; PHARMACOGENETICS; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME;

ANGIOTENSINOGEN; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; HYPERTENSION; INSULIN; KIDNEY; MALE; MICE;

EID: 84878877698     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2910-4     Document Type: Article

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