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M.C. Prieto-Carrasquero, H. Kobori, Y. Ozawa, A. Gutierrez, D. Seth, and L.G. Navar AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats Am J Physiol Renal Physiol 289 2005 F632 F637
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Prieto-Carrasquero, M.C.1
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Ozawa, Y.3
Gutierrez, A.4
Seth, D.5
Navar, L.G.6
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38
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0033848946
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Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats
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C.-T. Wang, S.Y. Chin, and L.G. Navar Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats Am J Physiol Renal Physiol 279 2000 F319 F325
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(2000)
Am J Physiol Renal Physiol
, vol.279
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Wang, C.-T.1
Chin, S.Y.2
Navar, L.G.3
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39
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Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice
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D. Zhao, D.M. Seth, and L.G. Navar Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice Hypertension 54 2009 120 126
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(2009)
Hypertension
, vol.54
, pp. 120-126
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Zhao, D.1
Seth, D.M.2
Navar, L.G.3
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40
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Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats
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M.C. Prieto-Carrasquero, F.T. Botros, J. Pagan, H. Kobori, D.M. Seth, D.E. Casarini, and L.G. Navar Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats Hypertension 51 2008 1590 1596
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(2008)
Hypertension
, vol.51
, pp. 1590-1596
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Prieto-Carrasquero, M.C.1
Botros, F.T.2
Pagan, J.3
Kobori, H.4
Seth, D.M.5
Casarini, D.E.6
Navar, L.G.7
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41
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79954459188
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Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats
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2011 in press, [Epub ahead of print]
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Prieto MC, Gonzalez-Villalobos RA, Botros FT, Martin VL, Pagan J, Sato R, Lara LS, Feng Y, Fernandez F, Kobori H, et al.: Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. Am J Physiol Renal Physiol, 2011 in press, [Epub ahead of print].
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Am J Physiol Renal Physiol
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Prieto, M.C.1
Gonzalez-Villalobos, R.A.2
Botros, F.T.3
Martin, V.L.4
Pagan, J.5
Sato, R.6
Lara, L.S.7
Feng, Y.8
Fernandez, F.9
Kobori, H.10
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42
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79952340670
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Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin i infusion
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in press, [ahead of print]
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Gonzalez-Villalobos RA, Billet S, Kim C, Satou R, Fuchs S, Bernstein KE, Navar LG: Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion. J Am Soc Nephrol, 2011, 22, in press, [ahead of print]. In this study, the authors used a special mouse model which expresses angiotensin-converting enzyme only in renal tubules. They demonstrated that chronic Ang I infusion increases blood pressure and only renal Ang II content, indicating that intrarenal Ang II formation plays an important role in development of hypertension.
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(2011)
J Am Soc Nephrol
, vol.22
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Gonzalez-Villalobos, R.A.1
Billet, S.2
Kim, C.3
Satou, R.4
Fuchs, S.5
Bernstein, K.E.6
Navar, L.G.7
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43
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0036266596
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Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
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DOI 10.1172/JCI200214276
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G. Nguyen, F. Delarue, C. Burckle, L. Bouzhir, T. Giller, and J.D. Sraer Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin J Clin Invest 109 2002 1417 1427 The authors report the expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single transmembrane domain. In transfected cells stably expressing the receptor, specific binding for renin and prorenin is demonstrated. The binding of renin induced a fourfold increase of the catalytic efficiency of angiotensinogen conversion to angiotensin I and induced an intracellular signal with phosphorylation of serine and tyrosine residues associated to an activation of MAP kinases ERK1 and ERK2. High levels of the receptor mRNA were detected in the heart, brain, placenta, and lower levels in the kidney and liver. This discovery opened new perspectives on the tissue renin-angiotensin system and on renin effects independent of angiotensin II. (Pubitemid 34596167)
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(2002)
Journal of Clinical Investigation
, vol.109
, Issue.11
, pp. 1417-1427
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Nguyen, G.1
Delarue, F.2
Burckle, C.3
Bouzhir, L.4
Giller, T.5
Sraer, J.-D.6
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44
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68549111147
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The (Pro)renin receptor: Site-specific and functional linkage to the vacuolar H+-ATPase in the kidney
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A. Advani, D.J. Kelly, A.J. Cox, K.E. White, S.L. Advani, K. Thai, K.A. Connelly, D. Yuen, J. Trogadis, and A.M. Herzenberg The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney Hypertension 54 2009 261 269 The expression of the (P)RR is shown predominantly at the apical side of the acid-secreting cells in the collecting duct. The co-localization and homology of the (P)RR with an accessory protein of the vacuolar H(+)-ATPase, suggests that the (P)RR may function primarily in distal nephron H(+) transport, recently noted to be, at least in part, an angiotensin II-dependent phenomenon.
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(2009)
Hypertension
, vol.54
, pp. 261-269
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Advani, A.1
Kelly, D.J.2
Cox, A.J.3
White, K.E.4
Advani, S.L.5
Thai, K.6
Connelly, K.A.7
Yuen, D.8
Trogadis, J.9
Herzenberg, A.M.10
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45
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79952751093
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Collecting duct renin: A critical link in angiotensin II-dependent hypertension
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M.C. Prieto, and L.G. Navar Collecting duct renin: a critical link in angiotensin II-dependent hypertension E.D. Frohlich, R.N. Re, The local cardiac renin-angiotensin aldosterone system 2009 Springer Science + Business Media, LLC New York 133 141
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(2009)
The Local Cardiac Renin-angiotensin Aldosterone System
, pp. 133-141
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Prieto, M.C.1
Navar, L.G.2
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47
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79551532780
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Enhancement of renin and prorenin receptor in the collecting ducts of Cyp1a1-Ren2 rats contribute to development and progression of malignant hypertension
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M.C. Prieto, D.E. Williams, L. Liu, K.L. Kavanagh, J.J. Mullins, and K.D. Mitchell Enhancement of renin and prorenin receptor in the collecting ducts of Cyp1a1-Ren2 rats contribute to development and progression of malignant hypertension Am J Physiol Renal Physiol 300 2011 F581 F588
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(2011)
Am J Physiol Renal Physiol
, vol.300
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Prieto, M.C.1
Williams, D.E.2
Liu, L.3
Kavanagh, K.L.4
Mullins, J.J.5
Mitchell, K.D.6
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48
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79953227634
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The soluble form of the prorenin receptor [S(PRR)] is augmented in the collecting ducts and in the urine of angiotensin II (Ang II)-dependent hypertensive rats
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in press, [ahead of print]
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Gonzalez AA, Lara LS, Seth DM, Prieto MC: The soluble form of the prorenin receptor [S(PRR)] is augmented in the collecting ducts and in the urine of angiotensin II (Ang II)-dependent hypertensive rats. Hypertension, 2011, 57, in press, [ahead of print].
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(2011)
Hypertension
, vol.57
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Gonzalez, A.L.1
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49
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Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension
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R.A. Gonzalez-Villalobos, R. Satou, D.M. Seth, L.C. Semprun-Prieto, A. Katsurada, H. Kobori, and L.G. Navar Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension Hypertension 53 2009 351 355
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(2009)
Hypertension
, vol.53
, pp. 351-355
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Gonzalez-Villalobos, R.A.1
Satou, R.2
Seth, D.M.3
Semprun-Prieto, L.C.4
Katsurada, A.5
Kobori, H.6
Navar, L.G.7
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