메뉴 건너뛰기




Volumn 11, Issue 2, 2011, Pages 180-186

Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; ANGIOTENSINOGEN; INTERLEUKIN 6; PRORENIN; PRORENIN RECEPTOR; RENIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 79954426057     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2011.01.009     Document Type: Review
Times cited : (134)

References (51)
  • 1
    • 34748859681 scopus 로고    scopus 로고
    • The intrarenal renin-angiotensin system: From physiology to the pathobiology of hypertension and kidney disease
    • DOI 10.1124/pr.59.3.3
    • H. Kobori, M. Nangaku, L.G. Navar, and A. Nishiyama The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease Pharmacol Rev 59 2007 251 287 (Pubitemid 47481436)
    • (2007) Pharmacological Reviews , vol.59 , Issue.3 , pp. 251-287
    • Kobori, H.1    Nangaku, M.2    Navar, L.G.3    Nishiyama, A.4
  • 4
    • 0036080547 scopus 로고    scopus 로고
    • Control of descending vasa recta pericyte membrane potential by angiotensin II
    • T.L. Pallone, and J.M. Huang Control of descending vasa recta pericyte membrane potential by angiotensin II Am J Physiol Renal Physiol 282 2002 F1064 F1074
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Pallone, T.L.1    Huang, J.M.2
  • 5
    • 42049113227 scopus 로고    scopus 로고
    • Kidney in hypertension: Guyton Redux
    • DOI 10.1161/HYPERTENSIONAHA.105.063636, PII 0000426820080400000001
    • T.M. Coffman, and S.D. Crowley Kidney in hypertension: guyton redux Hypertension 51 2008 811 816 (Pubitemid 351654684)
    • (2008) Hypertension , vol.51 , Issue.4 , pp. 811-816
    • Coffman, T.M.1    Crowley, S.D.2
  • 6
    • 54449089586 scopus 로고    scopus 로고
    • Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: Study in angiotensin II receptor subtype 1A knockout mice
    • L. Cervenka, I. Vaneckova, Z. Huskova, Z. Vanourkova, M. Erbanova, M. Thumova, P. Skaroupkova, M. Opocensky, J. Maly, and V.C. Chabova Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice J Hypertens 26 2008 1379 1389
    • (2008) J Hypertens , vol.26 , pp. 1379-1389
    • Cervenka, L.1    Vaneckova, I.2    Huskova, Z.3    Vanourkova, Z.4    Erbanova, M.5    Thumova, M.6    Skaroupkova, P.7    Opocensky, M.8    Maly, J.9    Chabova, V.C.10
  • 8
    • 33748655839 scopus 로고    scopus 로고
    • Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats
    • DOI 10.3317/jraas.2006.013
    • K.D. Mitchell, S.J. Bagatell, C.S. Miller, C.R. Mouton, D.M. Seth, and J.J. Mullins Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats J Renin Angiotensin Aldosterone Syst 7 2006 74 86 (Pubitemid 44383501)
    • (2006) JRAAS - Journal of the Renin-Angiotensin-Aldosterone System , vol.7 , Issue.2 , pp. 74-86
    • Mitchell, K.D.1    Bagatell, S.J.2    Miller, C.S.3    Mouton, C.R.4    Seth, D.M.5    Mullins, J.J.6
  • 9
    • 0031297091 scopus 로고    scopus 로고
    • A mouse view of hypertension
    • O. Smithies A mouse view of hypertension Hypertension 30 1997 1318 1324 (Pubitemid 27528069)
    • (1997) Hypertension , vol.30 , Issue.6 , pp. 1318-1324
    • Smithies, O.1
  • 11
    • 0036181980 scopus 로고    scopus 로고
    • Regulation of intrarenal angiotensin II in hypertension
    • DOI 10.1161/hy0202.103821
    • L.G. Navar, L.M. Harrison-Bernard, A. Nishiyama, and H. Kobori Regulation of intrarenal angiotensin II in hypertension Hypertension 39 2002 316 322 (Pubitemid 34165142)
    • (2002) Hypertension , vol.39 , Issue.2 II , pp. 316-322
    • Navar, L.G.1    Harrison-Bernard, L.M.2    Nishiyama, A.3    Kobori, H.4
  • 12
    • 2342527267 scopus 로고    scopus 로고
    • 1 Receptor Mediated Augmentation of Intrarenal Angiotensinogen in Angiotensin II-Dependent Hypertension
    • DOI 10.1161/01.HYP.0000122875.91100.28
    • H. Kobori, M.C. Prieto-Carrasquero, Y. Ozawa, and L.G. Navar AT1 receptor mediated augmentation of intrarenal angiotensinogen in angiotensin II-dependent hypertension Hypertension 43 2004 1126 1132 (Pubitemid 38579925)
    • (2004) Hypertension , vol.43 , Issue.5 , pp. 1126-1132
    • Kobori, H.1    Prieto-Carrasquero, M.C.2    Ozawa, Y.3    Navar, L.G.4
  • 13
    • 33847058515 scopus 로고    scopus 로고
    • Genetic susceptibility to essential hypertension: Insight from angiotensinogen
    • J.M. Lalouel, and A. Rohrwasser Genetic susceptibility to essential hypertension: insight from angiotensinogen Hypertension 49 2007 597 603
    • (2007) Hypertension , vol.49 , pp. 597-603
    • Lalouel, J.M.1    Rohrwasser, A.2
  • 14
    • 0029797409 scopus 로고    scopus 로고
    • Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats
    • L.X. Zou, J.D. Imig, A.M. Von Thun, A. Hymel, H. Ono, and L.G. Navar Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats Hypertension 28 1996 669 677 (Pubitemid 26327967)
    • (1996) Hypertension , vol.28 , Issue.4 , pp. 669-677
    • Zou, L.-X.1    Imig, J.D.2    Von Thun, A.M.3    Hymel, A.4    Ono, H.5    Navar, L.G.6
  • 15
    • 0142042336 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor-mediated augmentation of renal interstitial fluid angiotensin II in angiotensin II-induced hypertension
    • DOI 10.1097/00004872-200310000-00017
    • A. Nishiyama, D.M. Seth, and L.G. Navar Angiotensin II type 1 receptor-mediated augmentation of renal interstitial fluid angiotensin II in angiotensin II-induced hypertension J Hypertens 21 2003 1897 1903 (Pubitemid 37290108)
    • (2003) Journal of Hypertension , vol.21 , Issue.10 , pp. 1897-1903
    • Nishiyama, A.1    Seth, D.M.2    Navar, L.G.3
  • 16
    • 77955984130 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor-mediated augmentation of urinary excretion of endogenous angiotensin II in Val5-angiotensin II-infused rats
    • W. Shao, D.M. Seth, and L.G. Navar Angiotensin II type 1 receptor-mediated augmentation of urinary excretion of endogenous angiotensin II in Val5-angiotensin II-infused rats Hypertension 56 2010 378 383
    • (2010) Hypertension , vol.56 , pp. 378-383
    • Shao, W.1    Seth, D.M.2    Navar, L.G.3
  • 17
    • 66049105966 scopus 로고    scopus 로고
    • Augmentation of endogenous intrarenal angiotensin II levels in Val5-ANG II-infused rats
    • W. Shao, D.M. Seth, and L.G. Navar Augmentation of endogenous intrarenal angiotensin II levels in Val5-ANG II-infused rats Am J Physiol Renal Physiol 296 2009 F1067 F1071
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Shao, W.1    Seth, D.M.2    Navar, L.G.3
  • 18
    • 33846259795 scopus 로고    scopus 로고
    • Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions
    • Y. Ozawa, H. Kobori, Y. Suzaki, and L.G. Navar Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions Am J Physiol Renal Physiol 292 2007 F330 F339
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Ozawa, Y.1    Kobori, H.2    Suzaki, Y.3    Navar, L.G.4
  • 20
    • 0036433105 scopus 로고    scopus 로고
    • Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney
    • M. Ruiz-Ortega, M. Ruperez, O. Lorenzo, V. Esteban, J. Blanco, S. Mezzano, and J. Egido Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney Kidney Int Suppl 82 2002 S12 S22 The authors demonstrated that Ang II infusion stimulates intrarenal proinflammatory factors including TNF-α, IL-6 and MCP-1, and activates intrarenal NF-κB. These findings suggest that Ang II plays an active role in the inflammatory response in renal diseases.
    • (2002) Kidney Int Suppl , vol.82
    • Ruiz-Ortega, M.1    Ruperez, M.2    Lorenzo, O.3    Esteban, V.4    Blanco, J.5    Mezzano, S.6    Egido, J.7
  • 21
    • 0036347258 scopus 로고    scopus 로고
    • Vascular inflammation and the renin-angiotensin system
    • DOI 10.1161/01.ATV.0000021412.56621.A2
    • A.R. Brasier, A. Recinos III, and M.S. Eledrisi Vascular inflammation and the renin-angiotensin system Arterioscler Thromb Vasc Biol 22 2002 1257 1266 In this review, the authors provide evidence that Ang II has significant proinflammatory actions in the vascular wall, inducing the production of reactive oxygen species, inflammatory cytokines, and adhesion molecules. Furthermore, they propose an important role of Ang II-IL-6-JAK/STAT-AGT positive feedback system in the development of vascular inflammation. (Pubitemid 34875734)
    • (2002) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.22 , Issue.8 , pp. 1257-1266
    • Brasier, A.R.1    Recinos III, A.2    Eledrisi, M.S.3    Runge, M.S.4
  • 22
    • 78149243218 scopus 로고    scopus 로고
    • Interleukin 6 knockout prevents angiotensin II hypertension: Role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation
    • M.W. Brands, A.K. Banes-Berceli, E.W. Inscho, H. Al Azawi, A.J. Allen, and H. Labazi Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation Hypertension 56 2010 879 884 This paper reports that Ang II infusion decreases renal blood flow in both wild-type and IL-6 knockout mice although the increase in blood pressure caused by Ang II infusion was attenuated in IL-6 knockout mice. They also report that activation of JAK2/STAT3 pathway by the Ang II infusion in renal cortex was prevented in IL-6 knockout mice indicating that activation of the renal JAK2/STAT3 pathway plays a role in Ang II hypertension but not in the effect of Ang II to decrease total RBF.
    • (2010) Hypertension , vol.56 , pp. 879-884
    • Brands, M.W.1    Banes-Berceli, A.K.2    Inscho, E.W.3    Al Azawi, H.4    Allen, A.J.5    Labazi, H.6
  • 23
    • 33645744262 scopus 로고    scopus 로고
    • Angiotensin II hypertension is attenuated in interleukin-6 knockout mice
    • D.L. Lee, L.C. Sturgis, H. Labazi, J.B. Osborne Jr., C. Fleming, J.S. Pollock, M. Manhiani, J.D. Imig, and M.W. Brands Angiotensin II hypertension is attenuated in interleukin-6 knockout mice Am J Physiol Heart Circ Physiol 290 2006 H935 H940 The authors demonstrated that the increase in blood pressure by Ang II infusion is attenuated in IL-6 knockout mice. The finding indicates that IL-6 contributes to the development of Ang II-dependent hypertension.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Lee, D.L.1    Sturgis, L.C.2    Labazi, H.3    Osborne Jr., J.B.4    Fleming, C.5    Pollock, J.S.6    Manhiani, M.7    Imig, J.D.8    Brands, M.W.9
  • 24
    • 77957682461 scopus 로고    scopus 로고
    • Tumor necrosis factor-{alpha} suppresses angiotensinogen expression through formation of a p50/p50 homodimer in human renal proximal tubular cells
    • R. Satou, K. Miyata, A. Katsurada, L.G. Navar, and H. Kobori Tumor necrosis factor-{alpha} suppresses angiotensinogen expression through formation of a p50/p50 homodimer in human renal proximal tubular cells Am J Physiol Cell Physiol 299 2010 C750 C759
    • (2010) Am J Physiol Cell Physiol , vol.299
    • Satou, R.1    Miyata, K.2    Katsurada, A.3    Navar, L.G.4    Kobori, H.5
  • 27
    • 0037219640 scopus 로고    scopus 로고
    • Urinary angiotensinogen as an indicator of intrarenal angiotensin status in hypertension
    • DOI 10.1161/01.HYP.0000050102.90932.CF
    • H. Kobori, A. Nishiyama, L.M. Harrison-Bernard, and L.G. Navar Urinary angiotensinogen as an indicator of intrarenal angiotensin status in hypertension Hypertension 41 2003 42 49 (Pubitemid 36056790)
    • (2003) Hypertension , vol.41 , Issue.1 , pp. 42-49
    • Kobori, H.1    Nishiyama, A.2    Harrison-Bernard, L.M.3    Gabriel Navar, L.4
  • 28
    • 78149267757 scopus 로고    scopus 로고
    • A redox switch in angiotensinogen modulates angiotensin release
    • A. Zhou, R.W. Carrell, M.P. Murphy, Z. Wei, Y. Yan, P.L. Stanley, P.E. Stein, F.B. Pipkin, and R.J. Read A redox switch in angiotensinogen modulates angiotensin release Nature 468 2010 108 111 By evaluation of the crystal structures of the renin-AGT complex, the authors show the existence of two different structures of AGT dependent on an oxidative switch which may alter reactivity to renin. Moreover, they demonstrated that a ratio of these AGT forms is different in pre-eclampsia and suggest that the redox-response transition of angiotensinogen allows it to more readily release Ang II.
    • (2010) Nature , vol.468 , pp. 108-111
    • Zhou, A.1    Carrell, R.W.2    Murphy, M.P.3    Wei, Z.4    Yan, Y.5    Stanley, P.L.6    Stein, P.E.7    Pipkin, F.B.8    Read, R.J.9
  • 29
    • 78349310350 scopus 로고    scopus 로고
    • Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension
    • C.J. Milani, H. Kobori, J.J. Mullins, and K.D. Mitchell Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension Am J Med Sci 340 2010 389 394
    • (2010) Am J Med Sci , vol.340 , pp. 389-394
    • Milani, C.J.1    Kobori, H.2    Mullins, J.J.3    Mitchell, K.D.4
  • 30
    • 78650650377 scopus 로고    scopus 로고
    • Intrarenal renin angiotensin system revisited: Role of megalin-dependent endocytosis along the proximal nephron
    • M. Pohl, H. Kaminski, H. Castrop, M. Bader, N. Himmerkus, M. Bleich, S. Bachmann, and F. Theilig Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron J Biol Chem 285 2010 41935 41946 The authors reveal distributions of components of renin-angiotensin system in renal proximal tubular cells indicating that angiotensinogen mRNA expression is primarily localized to the latter segments of the proximal tubules. In addition, they demonstrate that AGT protein is taken up into renal proximal tubular cells via the megalin receptor.
    • (2010) J Biol Chem , vol.285 , pp. 41935-41946
    • Pohl, M.1    Kaminski, H.2    Castrop, H.3    Bader, M.4    Himmerkus, N.5    Bleich, M.6    Bachmann, S.7    Theilig, F.8
  • 31
    • 0036158053 scopus 로고    scopus 로고
    • Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production
    • DOI 10.1046/j.1523-1755.2002.00155.x
    • H. Kobori, L.M. Harrison-Bernard, and L.G. Navar Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production Kidney Int 61 2002 579 585 (Pubitemid 34102599)
    • (2002) Kidney International , vol.61 , Issue.2 , pp. 579-585
    • Kobori, H.1    Harrison-Bernard, L.M.2    Navar, L.G.3
  • 34
    • 77954386389 scopus 로고    scopus 로고
    • Urinary angiotensinogen is correlated with blood pressure in men (Bogalusa Heart Study)
    • H. Kobori, M. Urushihara, J.H. Xu, G.S. Berenson, and L.G. Navar Urinary angiotensinogen is correlated with blood pressure in men (Bogalusa Heart Study) J Hypertens 28 2010 1422 1428
    • (2010) J Hypertens , vol.28 , pp. 1422-1428
    • Kobori, H.1    Urushihara, M.2    Xu, J.H.3    Berenson, G.S.4    Navar, L.G.5
  • 35
    • 0033404955 scopus 로고    scopus 로고
    • Elements of a paracrine tubular renin-angiotensin system along the entire nephron
    • A. Rohrwasser, T. Morgan, H.F. Dillon, L. Zhao, C.W. Callaway, E. Hillas, S. Zhang, T. Cheng, T. Inagami, K. Ward, D.A. Terreros, and J.M. Lalouel Elements of a paracrine tubular renin-angiotensin system along the entire nephron Hypertension 34 1999 1265 1274 This seminal paper provides evidence of synthesis and secretion of angiotensinogen by polarized proximal tubule cells through its apical side. The protein can be detected in urine as a function of dietary sodium. Furthermore, renin is expressed and secreted in the connecting tubule, also in a sodium-dependent fashion. It is suggested that the paracrine RAS along the entire nephron may contribute to long-term arterial pressure regulation by integrating distinct tubular sodium-reabsorbing functions. (Pubitemid 30002393)
    • (1999) Hypertension , vol.34 , Issue.6 , pp. 1265-1274
    • Rohrwasser, A.1    Morgan, T.2    Dillon, H.F.3    Zhao, L.4    Callaway, C.W.5    Hillas, E.6    Zhang, S.7    Cheng, T.8    Inagami, T.9    Ward, K.10    Terreros, D.A.11    Lalouel, J.-M.12
  • 38
    • 0033848946 scopus 로고    scopus 로고
    • Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats
    • C.-T. Wang, S.Y. Chin, and L.G. Navar Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats Am J Physiol Renal Physiol 279 2000 F319 F325
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Wang, C.-T.1    Chin, S.Y.2    Navar, L.G.3
  • 39
    • 67649850599 scopus 로고    scopus 로고
    • Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice
    • D. Zhao, D.M. Seth, and L.G. Navar Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice Hypertension 54 2009 120 126
    • (2009) Hypertension , vol.54 , pp. 120-126
    • Zhao, D.1    Seth, D.M.2    Navar, L.G.3
  • 42
    • 79952340670 scopus 로고    scopus 로고
    • Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin i infusion
    • in press, [ahead of print]
    • Gonzalez-Villalobos RA, Billet S, Kim C, Satou R, Fuchs S, Bernstein KE, Navar LG: Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion. J Am Soc Nephrol, 2011, 22, in press, [ahead of print]. In this study, the authors used a special mouse model which expresses angiotensin-converting enzyme only in renal tubules. They demonstrated that chronic Ang I infusion increases blood pressure and only renal Ang II content, indicating that intrarenal Ang II formation plays an important role in development of hypertension.
    • (2011) J Am Soc Nephrol , vol.22
    • Gonzalez-Villalobos, R.A.1    Billet, S.2    Kim, C.3    Satou, R.4    Fuchs, S.5    Bernstein, K.E.6    Navar, L.G.7
  • 43
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    • DOI 10.1172/JCI200214276
    • G. Nguyen, F. Delarue, C. Burckle, L. Bouzhir, T. Giller, and J.D. Sraer Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin J Clin Invest 109 2002 1417 1427 The authors report the expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single transmembrane domain. In transfected cells stably expressing the receptor, specific binding for renin and prorenin is demonstrated. The binding of renin induced a fourfold increase of the catalytic efficiency of angiotensinogen conversion to angiotensin I and induced an intracellular signal with phosphorylation of serine and tyrosine residues associated to an activation of MAP kinases ERK1 and ERK2. High levels of the receptor mRNA were detected in the heart, brain, placenta, and lower levels in the kidney and liver. This discovery opened new perspectives on the tissue renin-angiotensin system and on renin effects independent of angiotensin II. (Pubitemid 34596167)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.11 , pp. 1417-1427
    • Nguyen, G.1    Delarue, F.2    Burckle, C.3    Bouzhir, L.4    Giller, T.5    Sraer, J.-D.6
  • 44
    • 68549111147 scopus 로고    scopus 로고
    • The (Pro)renin receptor: Site-specific and functional linkage to the vacuolar H+-ATPase in the kidney
    • A. Advani, D.J. Kelly, A.J. Cox, K.E. White, S.L. Advani, K. Thai, K.A. Connelly, D. Yuen, J. Trogadis, and A.M. Herzenberg The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney Hypertension 54 2009 261 269 The expression of the (P)RR is shown predominantly at the apical side of the acid-secreting cells in the collecting duct. The co-localization and homology of the (P)RR with an accessory protein of the vacuolar H(+)-ATPase, suggests that the (P)RR may function primarily in distal nephron H(+) transport, recently noted to be, at least in part, an angiotensin II-dependent phenomenon.
    • (2009) Hypertension , vol.54 , pp. 261-269
    • Advani, A.1    Kelly, D.J.2    Cox, A.J.3    White, K.E.4    Advani, S.L.5    Thai, K.6    Connelly, K.A.7    Yuen, D.8    Trogadis, J.9    Herzenberg, A.M.10
  • 45
    • 79952751093 scopus 로고    scopus 로고
    • Collecting duct renin: A critical link in angiotensin II-dependent hypertension
    • M.C. Prieto, and L.G. Navar Collecting duct renin: a critical link in angiotensin II-dependent hypertension E.D. Frohlich, R.N. Re, The local cardiac renin-angiotensin aldosterone system 2009 Springer Science + Business Media, LLC New York 133 141
    • (2009) The Local Cardiac Renin-angiotensin Aldosterone System , pp. 133-141
    • Prieto, M.C.1    Navar, L.G.2
  • 47
    • 79551532780 scopus 로고    scopus 로고
    • Enhancement of renin and prorenin receptor in the collecting ducts of Cyp1a1-Ren2 rats contribute to development and progression of malignant hypertension
    • M.C. Prieto, D.E. Williams, L. Liu, K.L. Kavanagh, J.J. Mullins, and K.D. Mitchell Enhancement of renin and prorenin receptor in the collecting ducts of Cyp1a1-Ren2 rats contribute to development and progression of malignant hypertension Am J Physiol Renal Physiol 300 2011 F581 F588
    • (2011) Am J Physiol Renal Physiol , vol.300
    • Prieto, M.C.1    Williams, D.E.2    Liu, L.3    Kavanagh, K.L.4    Mullins, J.J.5    Mitchell, K.D.6
  • 48
    • 79953227634 scopus 로고    scopus 로고
    • The soluble form of the prorenin receptor [S(PRR)] is augmented in the collecting ducts and in the urine of angiotensin II (Ang II)-dependent hypertensive rats
    • in press, [ahead of print]
    • Gonzalez AA, Lara LS, Seth DM, Prieto MC: The soluble form of the prorenin receptor [S(PRR)] is augmented in the collecting ducts and in the urine of angiotensin II (Ang II)-dependent hypertensive rats. Hypertension, 2011, 57, in press, [ahead of print].
    • (2011) Hypertension , vol.57
    • Gonzalez, A.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.