Novel benzoxazine-based aglycones block glucose uptake in vivo by inhibiting glycosidases

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Bharathkumar, Hanumantharayappa ^a   Sundaram, Mahalingam S ^b   Jagadish, Swamy ^b   Paricharak, Shardul ^c,d   Hemshekhar, Mahadevappa ^b   Mason, Daniel ^c   Kemparaju, Kempaiah ^b   Girish, Kesturu S ^b   Basappa, ^a   Bender, Andreas ^c   Rangappa, Kanchugarakoppal S ^b  

^a BANGALORE UNIVERSITY   (India)

^b UNIVERSITY OF MYSORE   (India)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1H INDOL 3 YL) 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZINE; 2 (2 BUTYL 4 CHLORO 1H IMIDAZOL 5 YL) 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZINE; 2 (2 METHYL 1H INDOL 3 YL) 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZINE; 3 (2,4 DIHYDRO 1H BENZO[D][1,3]OXAZIN 2 YL) 4H CHROMEN 4 ONE; 3 (6 CHLORO 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZIN 2 YL) 4H CHROMEN 4 ONE; 3 (6 METHYL 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZIN 2 YL) 4H CHROMEN 4 ONE; 4 (2,4 DIHYDRO 1H BENZO[D][1,3]OXAZIN 2 YL)PHENOL; 4 (7 CHLORO 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZIN 2 YL)PHENOL; 6 CHLORO 2 (2 PHENYL 1H INDOL 3 YL) 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZINE; 6 METHYL 2 (2 METHYL 1H INDOL 3 YL) 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZINE; 6 METHYL 2 (2 PHENYL 1H INDOL 3 YL) 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZINE; 7 CHLORO 2 (1H INDOL 3 YL) 2,4 DIHYDRO 1H BENZO[D][1,3]OXAZINE; ACARBOSE; AGLYCONE; ALPHA GLUCOSIDASE; AMYLASE; BENZOXAZINE DERIVATIVE; GLUCOSE; GLYCOSIDASE; MALTOSE; SODIUM GLUCOSE COTRANSPORTER 1; SUCROSE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CLASSIFIER; CONTROLLED STUDY; DRUG BINDING; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; GLUCOSE TRANSPORT; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; RAT; SWINE; ANIMAL; BAYES THEOREM; BINDING SITE; ENZYME SPECIFICITY; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS;

ANIMALS; BAYES THEOREM; BINDING SITES; DIABETES MELLITUS, TYPE 2; GLUCOSE; GLYCOSIDE HYDROLASES; RATS; SUBSTRATE SPECIFICITY;

EID: 84904537925     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102759     Document Type: Article

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