Immune activation and target organ damage are consequences of hydrodynamic treatment but not delivery of naked siRNAs in mice

Nucleic Acid Therapeutics

Volumn 21, Issue 3, 2011, Pages 215-224

  Rácz, Zsuzsanna ^a   Godó, Mária ^a   Révész, Csaba ^a   Hamar, Péter ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CYTOKINE; DOUBLE STRANDED RNA; ENZYME; INTERFERON; OLIGOADENYLATE SYNTHASE 1; POLYINOSINIC POLYCYTIDYLIC ACID; SMALL INTERFERING RNA; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE SILENCING; HYDRODYNAMICS; IMMUNOSTIMULATION; IN VIVO STUDY; LIVER CELL DAMAGE; MALE; MOUSE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TARGET ORGAN;

2',5'-OLIGOADENYLATE SYNTHETASE; ANIMALS; CYTOKINES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HYDRODYNAMICS; INTERFERONS; KIDNEY; LIVER; MALE; MICE; RNA, SMALL INTERFERING; SODIUM CHLORIDE; SPLEEN; STAT1 TRANSCRIPTION FACTOR;

MUS;

EID: 80052168845     PISSN: 21593337     EISSN: None     Source Type: Journal    
DOI: 10.1089/nat.2010.0248     Document Type: Article

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