Flavonoid ingredients of Ginkgo biloba leaf extract regulate lipid metabolism through Sp1-mediated carnitine palmitoyltranferase 1A up-regulation

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Wei, Ting ^a,c   Xiong, Fei Fei ^b,c   Wang, Shi Dong ^a,c   Wang, Ke ^c   Zhang, Yong Yu ^a   Zhang, Qing Hua ^a,b,c,d  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b TONGJI UNIVERSITY   (China)

^c National Engineering Center for Biochip at Shanghai   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

CPT1A; Flavonoid ingredients; Ginkgo biloba extract (GBE); Regulation; Sp1

Indexed keywords

CARNITINE PALMITOYLTRANFERASE 1A; CARNITINE PALMITOYLTRANSFERASE I; FLAVONOID; GINKGO BILOBA EXTRACT; ISORHAMNETIN; KAEMPFEROL; PROTEIN; QUERCETIN; SP1 PROTEIN; UNCLASSIFIED DRUG; CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE 1A, HUMAN; PLANT EXTRACT; SP1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SP1;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; FATTY ACID OXIDATION; GEL MOBILITY SHIFT ASSAY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPID STORAGE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RNA INTERFERENCE; UPREGULATION; CHEMISTRY; DRUG EFFECTS; GENETICS; GINKGO BILOBA; METABOLISM; PLANT LEAF;

CARNITINE O-PALMITOYLTRANSFERASE; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLAVONOIDS; GINKGO BILOBA; HEP G2 CELLS; HUMANS; LIPID METABOLISM; PLANT EXTRACTS; PLANT LEAVES; RNA INTERFERENCE; SP1 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 84907428186     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-014-0087-x     Document Type: Article

References (43)

1. Lifestyle modification as the primary treatment of NASH. BA Neuschwander-Tetri, Clin Liver Dis 2009 13 649 665 10.1016/j.cld.2009.07.006 19818311
2. Current treatment strategies for non-alcoholic fatty liver disease (NAFLD). P Mishra, ZM Younossi, Curr Drug Discov Technol 2007 4 133 140 10.2174/157016307781483469 17691915
3. Standard reference materials for foods and dietary supplements. KE Sharpless, JB Thomas, SJ Christopher, RR Greenberg, LC Sander, MM Schantz, MJ Welch, SA Wise, Anal Bioanal Chem 2007 389 171 178 10.1007/s00216-007-1315-y 17534610
4. Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet. X Gu, Z Xie, Q Wang, G Liu, Y Qu, L Zhang, J Pan, G Zhao, Q Zhang, FEBS J 2009 276 1450 1458 10.1111/j.1742-4658.2009.06886.x 19187224
5. Inhibitory effect of Ginkgo biloba extract on fatty liver: regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism. SD Wang, ZQ Xie, J Chen, K Wang, T Wei, AH Zhao, QH Zhang, J Dig Dis 2012 13 525 535 10.1111/j.1751-2980.2012.00627.x 22988926
6. Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. M Schreurs, F Kuipers, FR Van der Leij, Obes Rev 2010 11 380 388 10.1111/j.1467-789X.2009.00642.x 19694967
7. The mitochondrial carnitine palmitoyltransferase system: from concept to molecular analysis. JD McGarry, NF Brown, Eur J Biochem 1997 244 1 14 10.1111/j.1432-1033.1997.00001.x 9063439
8. A novel brain-expressed protein related to carnitine palmitoyltransferase I. N Price, F Van der Leij, V Jackson, C Corstorphine, R Thomson, A Sorensen, V Zammit, Genomics 2002 80 433 442 10.1006/geno.2002.6845 12376098
9. Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine. ES Shin, SY Cho, EH Lee, SJ Lee, IS Chang, TR Lee, Eur J Nutr 2006 45 159 164 10.1007/s00394-005-0576-5 16362726
10. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. M Rakhshandehroo, G Hooiveld, M Muller, S Kersten, PLoS One 2009 4 6796 10.1371/journal.pone.0006796 19710929
11. A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels. M Stefanovic-Racic, G Perdomo, BS Mantell, IJ Sipula, NF Brown, RM O'Doherty, Am J Physiol Endocrinol Metab 2008 294 969 E977 10.1152/ajpendo.00497.2007 18349115
12. Carnitine palmitoyltransferase-1A prevents free fatty acid induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. X Gao, K Li, X Hui, X Kong, G Sweeney, Y Wang, A Xu, M Teng, P Liu, D Wu, Biochem J 2011 435 723 732 10.1042/BJ20101680 21348853
13. Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. CR Bruce, AJ Hoy, N Turner, MJ Watt, TL Allen, K Carpenter, GJ Cooney, MA Febbraio, EW Kraegen, Diabetes 2009 58 550 558 10.2337/db08-1078 19073774
14. Recent advances in nonalcoholic fatty liver disease. O Cheung, AJ Sanyal, Curr Opin Gastroenterol 2010 26 202 208 10.1097/MOG.0b013e328337b0c4 20168226
15. Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. Z Xie, H Li, K Wang, J Lin, Q Wang, G Zhao, W Jia, Q Zhang, Metabolism 2010 59 554 560 10.1016/j.metabol.2009.08.022 19913842
16. Molecular mechanisms underlying the cholesterol-lowering effect of Ginkgo biloba extract in hepatocytes: a comparative study with lovastatin. ZQ Xie, G Liang, L Zhang, Q Wang, Y Qu, Y Gao, LB Lin, S Ye, J Zhang, H Wang, GP Zhao, QH Zhang, Acta Pharmacol Sin 2009 30 1262 1275 10.1038/aps.2009.126 19701231
17. Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes. CH Jung, I Cho, J Ahn, TI Jeon, TY Ha, Phytother Res 2012 27 139 143 10.1002/ptr.4687 22447684
18. Kaempferol regulates the lipid-profile in high-fat diet-fed rats through an increase in hepatic PPARalpha levels. CJ Chang, TF Tzeng, SS Liou, YS Chang, IM Liu, Planta Med 2011 77 1876 1882 10.1055/s-0031-1279992 21728151
19. Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. M Kobori, S Masumoto, Y Akimoto, H Oike, Mol Nutr Food Res 2011 55 530 540 10.1002/mnfr.201000392 21462320
20. Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. M Kohjima, M Enjoji, N Higuchi, M Kato, K Kotoh, T Yoshimoto, T Fujino, M Yada, R Yada, N Harada, R Takayanagi, M Nakamuta, Int J Mol Med 2007 20 351 358 17671740
21. Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. JK Reddy, T Hashimoto, Annu Rev Nutr 2001 21 193 230 10.1146/annurev.nutr.21.1.193 11375435
22. Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. K Shinozuka, K Umegaki, Y Kubota, N Tanaka, H Mizuno, J Yamauchi, K Nakamura, M Kunitomo, Life Sci 2002 70 2783 2792 10.1016/S0024-3205(02)01530-8 12269382
23. The role of Sp1 and Sp3 in normal and cancer cell biology. L Li, JR Davie, Ann Anat 2010 192 275 283 10.1016/j.aanat.2010.07.010 20810260
24. Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter. DP Singh, B Bhargavan, B Chhunchha, E Kubo, A Kumar, N Fatma, PLoS One 2012 7 37012 10.1371/journal.pone.0037012 22615874
25. Expression of the rat liver carnitine palmitoyltransferase I (CPT-Ialpha) gene is regulated by Sp1 and nuclear factor Y: chromosomal localization and promoter characterization. ML Steffen, WR Harrison, FF Elder, GA Cook, EA Park, Biochem J 1999 340 Pt 2 425 432 10.1042/0264-6021:3400425 10333485
26. Low pH enhances Sp1 DNA binding activity and interaction with TBP. T Torigoe, H Izumi, Y Yoshida, H Ishiguchi, T Okamoto, H Itoh, K Kohno, Nucleic Acids Res 2003 31 4523 4530 10.1093/nar/gkg487 12888513
27. Oestrogens and selective oestrogen receptor (ER) modulators regulate EGF receptor gene expression through human ER alpha and beta subtypes via an Sp1 site. L Salvatori, P Pallante, L Ravenna, P Chinzari, L Frati, MA Russo, E Petrangeli, Oncogene 2003 22 4875 4881 10.1038/sj.onc.1206784 12894229
28. Yin yang 1 (YY1) represses histidine decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site. W Ai, Y Liu, TC Wang, Am J Physiol Gastrointest Liver Physiol 2006 290 1096 G1104 10.1152/ajpgi.00199.2005 16357063
29. Sp1 and AP2 enhance promoter activity of the mouse GM3-synthase gene. T Xia, G Zeng, L Gao, RK Yu, Gene 2005 351 109 118 10.1016/j.gene.2005.03.010 15890474
30. Regulation of the activity of Sp1-related transcription factors. P Bouwman, S Philipsen, Mol Cell Endocrinol 2002 195 27 38 10.1016/S0303-7207(02)00221-6 12354670
31. Signal transduction and the control of gene expression. AH Brivanlou, JE Darnell Jr, Science 2002 295 813 818 10.1126/science.1066355 11823631
32. Sp1: regulation of gene expression by phosphorylation. S Chu, TJ Ferro, Gene 2005 348 1 11 10.1016/j.gene.2005.01.013 15777659
33. Role of p38 in stress activation of Sp1. M D'Addario, PD Arora, CA McCulloch, Gene 2006 379 51 61 10.1016/j.gene.2006.04.012 16797880
34. Quercetin induced tissue-type plasminogen activator expression is mediated through Sp1 and p38 mitogen-activated protein kinase in human endothelial cells. W Pan, MJ Chang, FM Booyse, HE Grenett, KM Bradley, PE Wolkowicz, Q Shang, EM Tabengwa, J Thromb Haemost 2008 6 976 985 10.1111/j.1538-7836.2008.02977.x 18419748
35. Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. C Pasten, NC Olave, L Zhou, EM Tabengwa, PE Wolkowicz, HE Grenett, Thromb Res 2007 121 59 65 10.1016/j.thromres.2007.02.001 17379280
36. Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. M Bao, Y Lou, Eur J Pharmacol 2006 547 22 30 10.1016/j.ejphar.2006.07.021 16963021
37. Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages. YC Chang, TS Lee, AN Chiang, J Lipid Res 2012 53 1840 1850 10.1194/jlr.M024471 22711909
38. Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. JY Kim, EH Kim, SS Park, JH Lim, TK Kwon, KS Choi, J Cell Biochem 2008 105 1386 1398 10.1002/jcb.21958 18980244
39. Estrogen response element-independent regulation of gene expression by genistein in intestinal cells. P Hua, WJ Tsai, SM Kuo, Biochim Biophys Acta 2003 1627 63 70 10.1016/S0167-4781(03)00075-7 12818423
40. Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation. Y Hirata, Y Masuda, H Kakutani, T Higuchi, K Takada, A Ito, Y Nakagawa, H Ishii, Biochem Pharmacol 2008 75 1504 1514 10.1016/j.bcp.2007.12.019 18261712
41. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. M Hamalainen, R Nieminen, P Vuorela, M Heinonen, E Moilanen, Mediators Inflamm 2007 2007 45673 10.1155/2007/45673 18274639
42. Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells. AB Granado-Serrano, MA Martin, L Bravo, L Goya, S Ramos, Nutr Cancer 2010 62 390 401 10.1080/01635580903441196 20358477
43. IL-1beta induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFkappaB/Ca(2)(+)-calmodulin/ERK mitogen-activated protein kinase signaling pathway. C Sticozzi, G Belmonte, A Meini, P Carbotti, G Grasso, M Palmi, Neuroscience 2013 252 367 383 10.1016/j.neuroscience.2013.07.061 23928073