-
1
-
-
22144432283
-
A systematic review of the prevalence of schizophrenia
-
Saha S, Chant D, Welham J, McGrath J. A systematic review of the prevalence of schizophrenia. PLoS Med. 2005;2: e141.
-
(2005)
PLoS Med.
, vol.2
-
-
Saha, S.1
Chant, D.2
Welham, J.3
McGrath, J.4
-
2
-
-
34547768323
-
The role of one-carbon metabolism in schizophrenia and depression
-
Frankenburg FR. The role of one-carbon metabolism in schizophrenia and depression. Harv Rev Psychiatry. 2007;15: 146-160.
-
(2007)
Harv Rev Psychiatry.
, vol.15
, pp. 146-160
-
-
Frankenburg, F.R.1
-
3
-
-
70949085092
-
Onecarbon metabolism and schizophrenia: Current challenges and future directions
-
Krebs MO, Bellon A, Mainguy G, Jay TM, Frieling H. Onecarbon metabolism and schizophrenia: current challenges and future directions. Trends Mol Med. 2009;15: 562-570.
-
(2009)
Trends Mol Med.
, vol.15
, pp. 562-570
-
-
Krebs, M.O.1
Bellon, A.2
Mainguy, G.3
Jay, T.M.4
Frieling, H.5
-
4
-
-
0029042491
-
Homocysteinemia is a common feature of schizophrenia
-
Regland B, Johansson BV, Grenfeldt B, Hjelmgren LT, Medhus M. Homocysteinemia is a common feature of schizophrenia. J Neural Transm Gen Sect. 1995;100: 165-169.
-
(1995)
J Neural Transm Gen Sect.
, vol.100
, pp. 165-169
-
-
Regland, B.1
Johansson, B.V.2
Grenfeldt, B.3
Hjelmgren, L.T.4
Medhus, M.5
-
5
-
-
0036787407
-
Elevated homocysteine levels in young male patients with schizophrenia
-
Levine J, Stahl Z, Sela BA, Gavendo S, Ruderman V, Belmaker RH. Elevated homocysteine levels in young male patients with schizophrenia. Am J Psychiatry. 2002;159: 1790-1792.
-
(2002)
Am J Psychiatry.
, vol.159
, pp. 1790-1792
-
-
Levine, J.1
Stahl, Z.2
Sela, B.A.3
Gavendo, S.4
Ruderman, V.5
Belmaker, R.H.6
-
6
-
-
2942566274
-
Homocysteine levels in newly admitted schizophrenic patients
-
Applebaum J, Shimon H, Sela BA, Belmaker RH, Levine J. Homocysteine levels in newly admitted schizophrenic patients. J Psychiatr Res. 2004;38: 413-416.
-
(2004)
J Psychiatr Res.
, vol.38
, pp. 413-416
-
-
Applebaum, J.1
Shimon, H.2
Sela, B.A.3
Belmaker, R.H.4
Levine, J.5
-
7
-
-
17744400085
-
Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677tt genotype, and the risk for schizophrenia: A dutch population based case-control study
-
Muntjewerff JW, Hoogendoorn ML, Kahn RS, et al. Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study. Am J Med Genet B Neuropsychiatr Genet. 2005;135B: 69-72.
-
(2005)
Am J Med Genet B Neuropsychiatr Genet.
, vol.135 B
, pp. 69-72
-
-
Muntjewerff, J.W.1
Hoogendoorn, M.L.2
Kahn, R.S.3
-
8
-
-
24944581659
-
Relation of plasma glycine, serine, and homocysteine levels to schizophrenia symptoms and medication type
-
Neeman G, Blanaru M, Bloch B, et al. Relation of plasma glycine, serine, and homocysteine levels to schizophrenia symptoms and medication type. Am J Psychiatry. 2005;162: 1738-1740.
-
(2005)
Am J Psychiatry.
, vol.162
, pp. 1738-1740
-
-
Neeman, G.1
Blanaru, M.2
Bloch, B.3
-
9
-
-
33745476473
-
Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in korean schizophrenic patients
-
Lee YS, Han DH, Jeon CM, et al. Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients. Neuroreport. 2006;17: 743-746.
-
(2006)
Neuroreport.
, vol.17
, pp. 743-746
-
-
Lee, Y.S.1
Han, D.H.2
Jeon, C.M.3
-
10
-
-
33751222898
-
Homocysteine levels in adolescent schizophrenia patients
-
Adler Nevo G, Meged S, Sela BA, Hanoch-Levi A, Hershko R, Weizman A. Homocysteine levels in adolescent schizophrenia patients. Eur Neuropsychopharmacol. 2006;16: 588-591.
-
(2006)
Eur Neuropsychopharmacol.
, vol.16
, pp. 588-591
-
-
Adler Nevo, G.1
Meged, S.2
Sela, B.A.3
Hanoch-Levi, A.4
Hershko, R.5
Weizman, A.6
-
11
-
-
34447626495
-
Plasma homocysteine, folate and b12 in chronic schizophrenia
-
Haidemenos A, Kontis D, Gazi A, Kallai E, Allin M, Lucia B. Plasma homocysteine, folate and B12 in chronic schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31: 1289-1296.
-
(2007)
Prog Neuropsychopharmacol Biol Psychiatry.
, vol.31
, pp. 1289-1296
-
-
Haidemenos, A.1
Kontis, D.2
Gazi, A.3
Kallai, E.4
Allin, M.5
Lucia, B.6
-
12
-
-
34548127980
-
Associations of blood homocysteine concentrations in arab schizophrenic patients
-
Akanji AO, Ohaeri JU, Al-Shammri SA, Fatania HR. Associations of blood homocysteine concentrations in Arab schizophrenic patients. Clin Biochem. 2007;40: 1026-1031.
-
(2007)
Clin Biochem.
, vol.40
, pp. 1026-1031
-
-
Akanji, A.O.1
Ohaeri, J.U.2
Al-Shammri, S.A.3
Fatania, H.R.4
-
13
-
-
43049104493
-
No association between global leukocyte dna methylation and homocysteine levels in schizophrenia patients
-
Bromberg A, Levine J, Nemetz B, Belmaker RH, Agam G. No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients. Schizophr Res. 2008;101: 50-57.
-
(2008)
Schizophr Res.
, vol.101
, pp. 50-57
-
-
Bromberg, A.1
Levine, J.2
Nemetz, B.3
Belmaker, R.H.4
Agam, G.5
-
14
-
-
56549107657
-
Plasma homocysteine levels in young male patients in the exacerbation and remission phase of schizophrenia
-
Petronijevic ND, Radonjic NV, Ivkovic MD, et al. Plasma homocysteine levels in young male patients in the exacerbation and remission phase of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32: 1921-1926.
-
(2008)
Prog Neuropsychopharmacol Biol Psychiatry.
, vol.32
, pp. 1921-1926
-
-
Petronijevic, N.D.1
Radonjic, N.V.2
Ivkovic, M.D.3
-
15
-
-
60049087756
-
Oxidative/nitrative modifications of plasma proteins and thiols from patients with schizophrenia
-
Dietrich-Muszalska A, Olas B, Glowacki R, Bald E. Oxidative/nitrative modifications of plasma proteins and thiols from patients with schizophrenia. Neuropsychobiology. 2009;59: 1-7.
-
(2009)
Neuropsychobiology.
, vol.59
, pp. 1-7
-
-
Dietrich-Muszalska, A.1
Olas, B.2
Glowacki, R.3
Bald, E.4
-
16
-
-
67650479568
-
Association of plasma homocysteine and methylenetetrahydrofolate reductase c677t gene variant with schizophrenia: A chinese han populationbased case-control study
-
Feng LG, Song ZW, Xin F, Hu J. Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han populationbased case-control study. Psychiatry Res. 2009;168: 205-208.
-
(2009)
Psychiatry Res.
, vol.168
, pp. 205-208
-
-
Feng, L.G.1
Song, Z.W.2
Xin, F.3
Hu, J.4
-
18
-
-
77952888355
-
Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase c677t polymorphism, are risk factors for schizophrenia
-
García-Miss Mdel R, Pérez-Mutul J, López-Canul B, et al. Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia. J Psychiatr Res. 2010;44: 441-446.
-
(2010)
J Psychiatr Res.
, vol.44
, pp. 441-446
-
-
García-Miss Mdel, R.1
Pérez-Mutul, J.2
López-Canul, B.3
-
19
-
-
72049102379
-
Reduced folic acid, vitamin b12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: Implications for altered one-carbon metabolism
-
Kale A, Naphade N, Sapkale S, et al. Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. Psychiatry Res. 2010;175: 47-53.
-
(2010)
Psychiatry Res.
, vol.175
, pp. 47-53
-
-
Kale, A.1
Naphade, N.2
Sapkale, S.3
-
20
-
-
77953289339
-
No gross abnormality of plasma homocysteine after acute methionine loading in clinically stabilized patients with schizophrenia
-
Shlafman N, Shaldubin S, Applebaum J, Belmaker RH, Levine J. No gross abnormality of plasma homocysteine after acute methionine loading in clinically stabilized patients with schizophrenia. Asian J Psychiatr. 2010;3: 64-66.
-
(2010)
Asian J Psychiatr.
, vol.3
, pp. 64-66
-
-
Shlafman, N.1
Shaldubin, S.2
Applebaum, J.3
Belmaker, R.H.4
Levine, J.5
-
21
-
-
79952199224
-
Serum total homocystein, folate and vitamin b12 levels and their correlation with antipsychotic drug doses in adult male patients with chronic schizophrenia
-
Eren E, Yegin A, Yilmaz N, Herken H. Serum total homocystein, folate and vitamin B12 levels and their correlation with antipsychotic drug doses in adult male patients with chronic schizophrenia. Clin Lab. 2010;56: 513-518.
-
(2010)
Clin Lab.
, vol.56
, pp. 513-518
-
-
Eren, E.1
Yegin, A.2
Yilmaz, N.3
Herken, H.4
-
22
-
-
79960953199
-
Serum homocysteine and folate levels in korean schizophrenic patients
-
Kim TH, Moon SW. Serum homocysteine and folate levels in korean schizophrenic patients. Psychiatry Investig. 2011;8: 134-140.
-
(2011)
Psychiatry Investig.
, vol.8
, pp. 134-140
-
-
Kim, T.H.1
Moon, S.W.2
-
23
-
-
84862895817
-
The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients
-
Dietrich-Muszalska A, Malinowska J, Olas B, et al. The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients. Neurochem Res. 2012;37: 1057-1062.
-
(2012)
Neurochem Res.
, vol.37
, pp. 1057-1062
-
-
Dietrich-Muszalska, A.1
Malinowska, J.2
Olas, B.3
-
24
-
-
84890367678
-
Elevated serum levels of homocysteine as an early prognostic factor of psychiatric disorders in children and adolescents
-
Kevere L, Purvina S, Bauze D, et al. Elevated serum levels of homocysteine as an early prognostic factor of psychiatric disorders in children and adolescents. Schizophr Res Treatment. 2012;2012: 373261.
-
(2012)
Schizophr Res Treatment.
, vol.2012
, pp. 373261
-
-
Kevere, L.1
Purvina, S.2
Bauze, D.3
-
25
-
-
0033551550
-
Plasma homocysteine and the methylenetetrahydrofolate reductase c677t gene variant: Lack of association with schizophrenia
-
Virgos C, Martorell L, Simó JM, et al. Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: lack of association with schizophrenia. Neuroreport. 1999;10: 2035-2038.
-
(1999)
Neuroreport.
, vol.10
, pp. 2035-2038
-
-
Virgos, C.1
Martorell, L.2
Simó, J.M.3
-
26
-
-
0142188577
-
Homocysteine metabolism and b-vitamins in schizophrenic patients: Low plasma folate as a possible independent risk factor for schizophrenia
-
Muntjewerff JW, van der Put N, Eskes T, et al. Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia. Psychiatry Res. 2003;121: 1-9.
-
(2003)
Psychiatry Res.
, vol.121
, pp. 1-9
-
-
Muntjewerff, J.W.1
Van Der Put, N.2
Eskes, T.3
-
27
-
-
4444355660
-
Folate, homocysteine, and negative symptoms in schizophrenia
-
Goff DC, Bottiglieri T, Arning E, et al. Folate, homocysteine, and negative symptoms in schizophrenia. Am J Psychiatry. 2004;161: 1705-1708.
-
(2004)
Am J Psychiatry.
, vol.161
, pp. 1705-1708
-
-
Goff, D.C.1
Bottiglieri, T.2
Arning, E.3
-
28
-
-
25644457397
-
Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase c677t and a1289c polymorphisms are not risk factors for schizophrenia
-
Vilella E, Virgos C, Murphy M, et al. Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29: 1169-1174.
-
(2005)
Prog Neuropsychopharmacol Biol Psychiatry.
, vol.29
, pp. 1169-1174
-
-
Vilella, E.1
Virgos, C.2
Murphy, M.3
-
29
-
-
41649110708
-
Altered red cell membrane compositions related to functional vitamin b(12) deficiency manifested by elevated urine methylmalonic acid concentrations in patients with schizophrenia
-
Ozcan O, Ipçioglu OM, Gültepe M, Basogglu C. Altered red cell membrane compositions related to functional vitamin B(12) deficiency manifested by elevated urine methylmalonic acid concentrations in patients with schizophrenia. Ann Clin Biochem. 2008;45: 44-49.
-
(2008)
Ann Clin Biochem.
, vol.45
, pp. 44-49
-
-
Ozcan, O.1
Ipçioglu, O.M.2
Gültepe, M.3
Basogglu, C.4
-
30
-
-
77955418465
-
Plasma homocysteine in schizophrenia: Determinants and clinical correlations in tunisian patients free from antipsychotics
-
Bouaziz N, Ayedi I, Sidhom O, et al. Plasma homocysteine in schizophrenia: determinants and clinical correlations in Tunisian patients free from antipsychotics. Psychiatry Res. 2010;179: 24-29.
-
(2010)
Psychiatry Res.
, vol.179
, pp. 24-29
-
-
Bouaziz, N.1
Ayedi, I.2
Sidhom, O.3
-
31
-
-
80051965486
-
Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia
-
Gysin R, Kraftsik R, Boulat O, et al. Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia. Antioxid Redox Signal. 2011;15: 2003-2010.
-
(2011)
Antioxid Redox Signal.
, vol.15
, pp. 2003-2010
-
-
Gysin, R.1
Kraftsik, R.2
Boulat, O.3
-
32
-
-
31544442693
-
Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: A meta-analysis
-
Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol Psychiatry. 2006;11: 143-149.
-
(2006)
Mol Psychiatry.
, vol.11
, pp. 143-149
-
-
Muntjewerff, J.W.1
Kahn, R.S.2
Blom, H.J.3
Den Heijer, M.4
-
33
-
-
0028788020
-
Total plasma homocysteine and cardiovascular risk profile. The hordaland homocysteine study
-
Nygård O, Vollset SE, Refsum H, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA. 1995;274: 1526-1533.
-
(1995)
JAMA
, vol.274
, pp. 1526-1533
-
-
Nygård, O.1
Vollset, S.E.2
Refsum, H.3
-
34
-
-
70449560459
-
Novel associations of cps1, mut, nox4, and dpep1 with plasma homocysteine in a healthy population: A genome-wide evaluation of 13 974 participants in the women's genome health study
-
doi: 10.1161/ CIRCGENETICS.108.829804
-
Paré G, Chasman DI, Parker AN, et al. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. Circ Cardiovasc Genet. 2009;2: 142-150. doi: 10.1161/ CIRCGENETICS.108.829804.
-
(2009)
Circ Cardiovasc Genet.
, vol.2
, pp. 142-150
-
-
Paré, G.1
Chasman, D.I.2
Parker, A.N.3
-
35
-
-
70449553669
-
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
-
Hazra A, Kraft P, Lazarus R, et al. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet. 2009;18: 4677-4687.
-
(2009)
Hum Mol Genet.
, vol.18
, pp. 4677-4687
-
-
Hazra, A.1
Kraft, P.2
Lazarus, R.3
-
36
-
-
0029049553
-
A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
-
Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10: 111-113.
-
(1995)
Nat Genet.
, vol.10
, pp. 111-113
-
-
Frosst, P.1
Blom, H.J.2
Milos, R.3
-
37
-
-
0030823373
-
Methylenetetrahydrofolate reductase variant and schizophrenia/depression
-
Arinami T, Yamada N, Yamakawa-Kobayashi K, Hamaguchi H, Toru M. Methylenetetrahydrofolate reductase variant and schizophrenia/depression. Am J Med Genet. 1997;74: 526-528.
-
(1997)
Am J Med Genet.
, vol.74
, pp. 526-528
-
-
Arinami, T.1
Yamada, N.2
Yamakawa-Kobayashi, K.3
Hamaguchi, H.4
Toru, M.5
-
38
-
-
0031665509
-
C677t polymorphism in methylenetetrahydrofolate reductase gene and psychoses
-
Kunugi H, Fukuda R, Hattori M, et al. C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses. Mol Psychiatry. 1998;3: 435-437.
-
(1998)
Mol Psychiatry.
, vol.3
, pp. 435-437
-
-
Kunugi, H.1
Fukuda, R.2
Hattori, M.3
-
39
-
-
78249274507
-
Gene-wide association study between the methylenetetrahydrofolate reductase gene (mthfr) and schizophrenia in the japanese population, with an updated meta-analysis on currently available data
-
Yoshimi A, Aleksic B, Kawamura Y, et al. Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data. Schizophr Res. 2010;124: 216-222.
-
(2010)
Schizophr Res.
, vol.124
, pp. 216-222
-
-
Yoshimi, A.1
Aleksic, B.2
Kawamura, Y.3
-
40
-
-
80053555100
-
The genetic validation of heterogeneity in schizophrenia
-
Tsutsumi A, Glatt SJ, Kanazawa T, et al. The genetic validation of heterogeneity in schizophrenia. Behav Brain Funct. 2011;7: 43.
-
(2011)
Behav Brain Funct.
, vol.7
, pp. 43
-
-
Tsutsumi, A.1
Glatt, S.J.2
Kanazawa, T.3
-
41
-
-
46249104490
-
Systematic metaanalyses and field synopsis of genetic association studies in schizophrenia: The szgene database
-
Allen NC, Bagade S, McQueen MB, et al. Systematic metaanalyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 2008;40: 827-834.
-
(2008)
Nat Genet.
, vol.40
, pp. 827-834
-
-
Allen, N.C.1
Bagade, S.2
McQueen, M.B.3
-
42
-
-
33845887461
-
Methylenetetrahydrofolate reductase (mthfr) genetic polymorphisms and psychiatric disorders: A huge review
-
Gilbody S, Lewis S, Lightfoot T. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol. 2007;165: 1-13.
-
(2007)
Am J Epidemiol.
, vol.165
, pp. 1-13
-
-
Gilbody, S.1
Lewis, S.2
Lightfoot, T.3
-
43
-
-
51449116741
-
Two methylenetetrahydrofolate reductase gene (mthfr) polymorphisms, schizophrenia and bipolar disorder: An association study
-
Jönsson EG, Larsson K, Vares M, et al. Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study. Am J Med Genet B Neuropsychiatr Genet. 2008;147B: 976-982.
-
(2008)
Am J Med Genet B Neuropsychiatr Genet.
, vol.147 B
, pp. 976-982
-
-
Jönsson, E.G.1
Larsson, K.2
Vares, M.3
-
45
-
-
80053911645
-
Meta-analysis of mthfr gene variants in schizophrenia bipolar disorder and unipolar depressive disorder: Evidence for a common genetic vulnerability?
-
MTHFR in Psychiatry Group
-
Peerbooms OL, van Os J, Drukker M, et al.; MTHFR in Psychiatry Group. Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability? Brain Behav Immun. 2011;25: 1530-1543.
-
(2011)
Brain Behav Immun.
, vol.25
, pp. 1530-1543
-
-
Peerbooms, O.L.1
Van Os, J.2
Drukker, M.3
-
46
-
-
50249135384
-
Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes
-
Shi J, Gershon ES, Liu C. Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr Res. 2008;104: 96-107.
-
(2008)
Schizophr Res.
, vol.104
, pp. 96-107
-
-
Shi, J.1
Gershon, E.S.2
Liu, C.3
-
47
-
-
33746792898
-
C677t and a1298c methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: A meta-analysis of genetic association studies
-
Zintzaras E. C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies. Psychiatr Genet. 2006;16: 105-115.
-
(2006)
Psychiatr Genet.
, vol.16
, pp. 105-115
-
-
Zintzaras, E.1
-
48
-
-
18444405551
-
What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?
-
Davey Smith G, Ebrahim S. What can mendelian randomisation tell us about modifiable behavioural and environmental exposures? BMJ. 2005;330: 1076-1079.
-
(2005)
BMJ
, vol.330
, pp. 1076-1079
-
-
Davey Smith, G.1
Ebrahim, S.2
-
49
-
-
84872042939
-
Use of mendelian randomisation to assess potential benefit of clinical intervention
-
Burgess S, Butterworth A, Malarstig A, Thompson SG. Use of Mendelian randomisation to assess potential benefit of clinical intervention. BMJ. 2012;345: e7325.
-
(2012)
BMJ
, vol.345
-
-
Burgess, S.1
Butterworth, A.2
Malarstig, A.3
Thompson, S.G.4
-
50
-
-
84866936868
-
Meta-analysis of association studies between disc1 missense variants and schizophrenia in the japanese population
-
Kinoshita M, Numata S, Tajima A, et al. Meta-analysis of association studies between DISC1 missense variants and schizophrenia in the Japanese population. Schizophr Res. 2012;141: 271-273.
-
(2012)
Schizophr Res.
, vol.141
, pp. 271-273
-
-
Kinoshita, M.1
Numata, S.2
Tajima, A.3
-
51
-
-
79956157001
-
No association between the pcm1 gene and schizophrenia: A multi-center case-control study and a meta-analysis
-
Hashimoto R, Ohi K, Yasuda Y, et al. No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. Schizophr Res. 2011;129: 80-84.
-
(2011)
Schizophr Res.
, vol.129
, pp. 80-84
-
-
Hashimoto, R.1
Ohi, K.2
Yasuda, Y.3
-
52
-
-
0023628783
-
Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection
-
Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr. 1987;422: 43-52.
-
(1987)
J Chromatogr.
, vol.422
, pp. 43-52
-
-
Araki, A.1
Sako, Y.2
-
53
-
-
84879529900
-
Serum iron levels and the risk of parkinson disease: A mendelian randomization study
-
PD GWAS Consortium; International Parkinson's Disease Genomics Consortium; Wellcome Trust Case Control Consortium 2; Genetics of Iron Status Consortium
-
Pichler I, Del Greco M F, Gögele M, et al.; PD GWAS Consortium; International Parkinson's Disease Genomics Consortium; Wellcome Trust Case Control Consortium 2; Genetics of Iron Status Consortium. Serum iron levels and the risk of Parkinson disease: a mendelian randomization study. PLoS Med. 2013;10: e1001462.
-
(2013)
PLoS Med.
, vol.10
-
-
Pichler, I.1
Del Greco M, F.2
Gögele, M.3
-
54
-
-
33747071747
-
Estimation of bias in nongenetic observational studies using "mendelian triangulation"
-
Bautista LE, Smeeth L, Hingorani AD, Casas JP. Estimation of bias in nongenetic observational studies using "mendelian triangulation". Ann Epidemiol. 2006;16: 675-680.
-
(2006)
Ann Epidemiol.
, vol.16
, pp. 675-680
-
-
Bautista, L.E.1
Smeeth, L.2
Hingorani, A.D.3
Casas, J.P.4
-
55
-
-
34250655804
-
Re: Estimation of bias in nongenetic observational studies using "mendelian triangulation" by bautista et al
-
Thomas DC, Lawlor DA, Thompson JR. Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al. Ann Epidemiol. 2007;17: 511-513.
-
(2007)
Ann Epidemiol.
, vol.17
, pp. 511-513
-
-
Thomas, D.C.1
Lawlor, D.A.2
Thompson, J.R.3
-
56
-
-
0030922816
-
Bias in meta-analysis detected by a simple, graphical test
-
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315: 629-634.
-
(1997)
BMJ
, vol.315
, pp. 629-634
-
-
Egger, M.1
Davey Smith, G.2
Schneider, M.3
Minder, C.4
-
57
-
-
82255175589
-
Genome-wide association study identifies a susceptibility locus for schizophrenia in han chinese at 11p11.2
-
Yue WH, Wang HF, Sun LD, et al. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet. 2011;43: 1228-1231.
-
(2011)
Nat Genet.
, vol.43
, pp. 1228-1231
-
-
Yue, W.H.1
Wang, H.F.2
Sun, L.D.3
-
58
-
-
68449090594
-
Common variants conferring risk of schizophrenia
-
Genetic Risk and Outcome in Psychosis (GROUP)
-
Stefansson H, Ophoff RA, Steinberg S, et al.; Genetic Risk and Outcome in Psychosis (GROUP). Common variants conferring risk of schizophrenia. Nature. 2009;460: 744-747.
-
(2009)
Nature.
, vol.460
, pp. 744-747
-
-
Stefansson, H.1
Ophoff, R.A.2
Steinberg, S.3
-
59
-
-
80053384370
-
Genome-wide association study identifies five new schizophrenia loci
-
Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
-
Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011;43: 969-976.
-
(2011)
Nat Genet.
, vol.43
, pp. 969-976
-
-
-
60
-
-
33845993973
-
Elevated prenatal homocysteine levels as a risk factor for schizophrenia
-
Brown AS, Bottiglieri T, Schaefer CA, et al. Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Arch Gen Psychiatry. 2007;64: 31-39.
-
(2007)
Arch Gen Psychiatry.
, vol.64
, pp. 31-39
-
-
Brown, A.S.1
Bottiglieri, T.2
Schaefer, C.A.3
-
61
-
-
70350145603
-
Effects of s-adenosylhomocysteine and homocysteine on dna damage and cell cytotoxicity in murine hepatic and microglia cell lines
-
Liu CC, Ho WY, Leu KL, Tsai HM, Yang TH. Effects of S- adenosylhomocysteine and homocysteine on DNA damage and cell cytotoxicity in murine hepatic and microglia cell lines. J Biochem Mol Toxicol. 2009;23: 349-356.
-
(2009)
J Biochem Mol Toxicol.
, vol.23
, pp. 349-356
-
-
Liu, C.C.1
Ho, W.Y.2
Leu, K.L.3
Tsai, H.M.4
Yang, T.H.5
-
62
-
-
0034666267
-
Homocysteine elicits a dna damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
-
Kruman II, Culmsee C, Chan SL, et al. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci. 2000;20: 6920-6926.
-
(2000)
J Neurosci.
, vol.20
, pp. 6920-6926
-
-
Kruman, I.I.1
Culmsee, C.2
Chan, S.L.3
-
63
-
-
27644581655
-
Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia
-
Tyagi N, Moshal KS, Ovechkin AV, et al. Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia. J Cell Biochem. 2005;96: 665-671.
-
(2005)
J Cell Biochem.
, vol.96
, pp. 665-671
-
-
Tyagi, N.1
Moshal, K.S.2
Ovechkin, A.V.3
-
64
-
-
84891713356
-
Plasma total homocysteine is associated with dna methylation in patients with schizophrenia
-
Kinoshita M, Numata S, Tajima A, Shimodera S, Imoto I, Ohmori T. Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia. Epigenetics. 2013;8: 584-590.
-
(2013)
Epigenetics.
, vol.8
, pp. 584-590
-
-
Kinoshita, M.1
Numata, S.2
Tajima, A.3
Shimodera, S.4
Imoto, I.5
Ohmori, T.6
-
65
-
-
84862258323
-
Prenatal nutrition, epigenetics and schizophrenia risk: Can we test causal effects?
-
Kirkbride JB, Susser E, Kundakovic M, Kresovich JK, Davey Smith G, Relton CL. Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects? Epigenomics. 2012;4: 303-315.
-
(2012)
Epigenomics.
, vol.4
, pp. 303-315
-
-
Kirkbride, J.B.1
Susser, E.2
Kundakovic, M.3
Kresovich, J.K.4
Davey Smith, G.5
Relton, C.L.6
-
66
-
-
33746257104
-
Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia
-
Levine J, Stahl Z, Sela BA, et al. Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia. Biol Psychiatry. 2006;60: 265-269.
-
(2006)
Biol Psychiatry.
, vol.60
, pp. 265-269
-
-
Levine, J.1
Stahl, Z.2
Sela, B.A.3
-
67
-
-
79952316920
-
Folate supplementation in schizophrenia: A possible role for mthfr genotype
-
Hill M, Shannahan K, Jasinski S, et al. Folate supplementation in schizophrenia: a possible role for MTHFR genotype. Schizophr Res. 2011;127: 41-45.
-
(2011)
Schizophr Res.
, vol.127
, pp. 41-45
-
-
Hill, M.1
Shannahan, K.2
Jasinski, S.3
-
68
-
-
84876925332
-
Randomized multicenter investigation of folate plus vitamin b12 supplementation in schizophrenia
-
Roffman JL, Lamberti JS, Achtyes E, et al. Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia. JAMA Psychiatry. 2013;70: 481-489.
-
(2013)
JAMA Psychiatry.
, vol.70
, pp. 481-489
-
-
Roffman, J.L.1
Lamberti, J.S.2
Achtyes, E.3
-
69
-
-
1342309318
-
Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The vitamin intervention for stroke prevention (visp) randomized controlled trial
-
Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004;291: 565-575.
-
(2004)
JAMA
, vol.291
, pp. 565-575
-
-
Toole, J.F.1
Malinow, M.R.2
Chambless, L.E.3
-
70
-
-
27644521579
-
Vitamin intervention for stroke prevention trial: An efficacy analysis
-
Spence JD, Bang H, Chambless LE, Stampfer MJ. Vitamin Intervention For Stroke Prevention trial: an efficacy analysis. Stroke. 2005;36: 2404-2409.
-
(2005)
Stroke.
, vol.36
, pp. 2404-2409
-
-
Spence, J.D.1
Bang, H.2
Chambless, L.E.3
Stampfer, M.J.4
-
71
-
-
85041836740
-
Homocysteine-lowering interventions for preventing cardiovascular events
-
Martí-Carvajal AJ, Solà I, Lathyris D, Karakitsiou DE, Simancas-Racines D. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2013;1: CD006612.
-
(2013)
Cochrane Database Syst Rev.
, vol.1
-
-
Martí-Carvajal, A.J.1
Solà, I.2
Lathyris, D.3
Karakitsiou, D.E.4
Simancas-Racines, D.5
-
72
-
-
84872388607
-
Genetic polymorphism of methylenetetrahydrofolate reductase and risk of aggressive behaviour in schizophrenia
-
Dong ZQ, Tian YY, Guan X, et al. Genetic polymorphism of methylenetetrahydrofolate reductase and risk of aggressive behaviour in schizophrenia. Psychiatry Res. 2012;200: 1082.
-
(2012)
Psychiatry Res.
, vol.200
, pp. 1082
-
-
Dong, Z.Q.1
Tian, Y.Y.2
Guan, X.3
-
73
-
-
84874354263
-
Comt and mthfr polymorphisms interaction on cognition in schizophrenia: An exploratory study
-
Kontis D, Theochari E, Fryssira H, et al. COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study. Neurosci Lett. 2013;537: 17-22.
-
(2013)
Neurosci Lett.
, vol.537
, pp. 17-22
-
-
Kontis, D.1
Theochari, E.2
Fryssira, H.3
-
74
-
-
34147138840
-
Effects of the methylenetetrahydrofolate reductase (mthfr) c677t polymorphism on executive function in schizophrenia
-
Roffman JL, Weiss AP, Deckersbach T, et al. Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia. Schizophr Res. 2007;92: 181-188.
-
(2007)
Schizophr Res.
, vol.92
, pp. 181-188
-
-
Roffman, J.L.1
Weiss, A.P.2
Deckersbach, T.3
-
75
-
-
56249097252
-
Mthfr 677c rarr; t genotype disrupts prefrontal function in schizophrenia through an interaction with comt 158val rarr; met
-
Roffman JL, Gollub RL, Calhoun VD, et al. MTHFR 677C rarr; T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val rarr; Met. Proc Natl Acad Sci U S A. 2008;105: 17573-17578.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, pp. 17573-17578
-
-
Roffman, J.L.1
Gollub, R.L.2
Calhoun, V.D.3
-
76
-
-
36848999415
-
Contribution of methylenetetrahydrofolate reductase (mthfr) polymorphisms to negative symptoms in schizophrenia
-
Roffman JL, Weiss AP, Purcell S, et al. Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia. Biol Psychiatry. 2008;63: 42-48.
-
(2008)
Biol Psychiatry.
, vol.63
, pp. 42-48
-
-
Roffman, J.L.1
Weiss, A.P.2
Purcell, S.3
-
77
-
-
78751643695
-
Mthfr 677c>t effects on anterior cingulate structure and function during response monitoring in schizophrenia: A preliminary study
-
Roffman JL, Brohawn DG, Friedman JS, et al. MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary study. Brain Imaging Behav. 2011;5: 65-75.
-
(2011)
Brain Imaging Behav.
, vol.5
, pp. 65-75
-
-
Roffman, J.L.1
Brohawn, D.G.2
Friedman, J.S.3
-
78
-
-
80053244796
-
A hypomethylating variant of mthfr, 677c>t, blunts the neural response to errors in patients with schizophrenia and healthy individuals
-
Roffman JL, Nitenson AZ, Agam Y, et al. A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals. PLoS One. 2011;6: e25253.
-
(2011)
PLoS One.
, vol.6
-
-
Roffman, J.L.1
Nitenson, A.Z.2
Agam, Y.3
-
79
-
-
84874528259
-
Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia
-
Roffman JL, Brohawn DG, Nitenson AZ, Macklin EA, Smoller JW, Goff DC. Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia. Schizophr Bull. 2013;39: 330-338.
-
(2013)
Schizophr Bull.
, vol.39
, pp. 330-338
-
-
Roffman, J.L.1
Brohawn, D.G.2
Nitenson, A.Z.3
Macklin, E.A.4
Smoller, J.W.5
Goff, D.C.6
-
80
-
-
84873818934
-
Association of mthfr c677t polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients
-
Zhang Y, Yan H, Tian L, et al. Association of MTHFR C677T polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients. Behav Brain Res. 2013;243: 146-152.
-
(2013)
Behav Brain Res.
, vol.243
, pp. 146-152
-
-
Zhang, Y.1
Yan, H.2
Tian, L.3
-
81
-
-
36849066949
-
Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (mthfr) 677c/t and 1298a/c variants
-
Ellingrod VL, Miller DD, Taylor SF, Moline J, Holman T, Kerr J. Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants. Schizophr Res. 2008;98: 47-54.
-
(2008)
Schizophr Res.
, vol.98
, pp. 47-54
-
-
Ellingrod, V.L.1
Miller, D.D.2
Taylor, S.F.3
Moline, J.4
Holman, T.5
Kerr, J.6
-
82
-
-
84857911892
-
Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: The role of folate pharmacogenetics
-
Ellingrod VL, Taylor SF, Dalack G, et al. Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics. J Clin Psychopharmacol. 2012;32: 261-265.
-
(2012)
J Clin Psychopharmacol.
, vol.32
, pp. 261-265
-
-
Ellingrod, V.L.1
Taylor, S.F.2
Dalack, G.3
-
83
-
-
84865001811
-
Group investigators. Clinical response to antipsychotic drug treatment: Association study of polymorphisms in six candidate genes
-
Vehof J, Burger H, Wilffert B, Al Hadithy A, Alizadeh BZ, Snieder H; GROUP investigators. Clinical response to antipsychotic drug treatment: association study of polymorphisms in six candidate genes. Eur Neuropsychopharmacol. 2012;22: 625-631.
-
(2012)
Eur Neuropsychopharmacol.
, vol.22
, pp. 625-631
-
-
Vehof, J.1
Burger, H.2
Wilffert, B.3
Al Hadithy, A.4
Alizadeh, B.Z.5
Snieder, H.6
-
84
-
-
0033945511
-
Association between the methylenetetrahydrofolate reductase 677crarr;t missense mutation and schizophrenia
-
Joober R, Benkelfat C, Lal S, et al. Association between the methylenetetrahydrofolate reductase 677Crarr;T missense mutation and schizophrenia. Mol Psychiatry. 2000;5: 323-326.
-
(2000)
Mol Psychiatry.
, vol.5
, pp. 323-326
-
-
Joober, R.1
Benkelfat, C.2
Lal, S.3
-
85
-
-
79956025783
-
The use of well controls: An unhealthy practice in psychiatric research
-
Schwartz S, Susser E. The use of well controls: an unhealthy practice in psychiatric research. Psychol Med. 2011;41: 1127-1131.
-
(2011)
Psychol Med.
, vol.41
, pp. 1127-1131
-
-
Schwartz, S.1
Susser, E.2
-
86
-
-
54149092989
-
On the use of mendelian randomization to infer causality in observational epidemiology
-
Bochud M. On the use of Mendelian randomization to infer causality in observational epidemiology. Eur Heart J. 2008;29: 2456-2457.
-
(2008)
Eur Heart J.
, vol.29
, pp. 2456-2457
-
-
Bochud, M.1
-
87
-
-
55749092488
-
Homocysteine and depression in later life
-
Almeida OP, McCaul K, Hankey GJ, Normand P, Jamrozik K, Flicker L. Homocysteine and depression in later life. Arch Gen Psychiatry. 2008;65: 1286-1294.
-
(2008)
Arch Gen Psychiatry.
, vol.65
, pp. 1286-1294
-
-
Almeida, O.P.1
McCaul, K.2
Hankey, G.J.3
Normand, P.4
Jamrozik, K.5
Flicker, L.6
-
88
-
-
79960759869
-
Serum homocysteine and dementia: Meta-analysis of eight cohort studies including 8669 participants
-
Wald DS, Kasturiratne A, Simmonds M. Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants. Alzheimers Dement. 2011;7: 412-417.
-
(2011)
Alzheimers Dement.
, vol.7
, pp. 412-417
-
-
Wald, D.S.1
Kasturiratne, A.2
Simmonds, M.3
|