On the use of Mendelian randomization to infer causality in observational epidemiology

European Heart Journal

Volumn 29, Issue 20, 2008, Pages 2456-2457

  Bochud, Murielle ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; FIBRINOGEN;

ALLELE; ARTERIAL WALL THICKNESS; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR RISK; CAROTID ARTERY; EDITORIAL; EPIDEMIOLOGICAL DATA; GAMETE; GENETIC ALGORITHM; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTIMA; MENDELIAN RANDOMIZATION; METHODOLOGY; OBSERVATIONAL STUDY; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZATION; SINGLE NUCLEOTIDE POLYMORPHISM; THEORETICAL MODEL; TUNICA MEDIA;

BODY MASS INDEX; CAUSALITY; EPIDEMIOLOGY, MOLECULAR; GENETIC VARIATION; HUMANS; RECOMBINATION, GENETIC;

EID: 54149092989     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehn428     Document Type: Editorial

References (13)

1. Ebrahim S, Davey SG. Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet 2008;123:15-33.
2. Didelez V, Sheehan N. Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res 2007;16:309- 330.
3. Davey Smith G, Ebrahim S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
4. Thomas DC, Conti DV. Commentary: the concept of 'Mendelian Randomization'. Int J Epidemiol 2004;33:21-25.
5. Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey SG. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 2007;27:1133-1163.
6. Kivimäki M, Davey Smith G, Timpson NJ, Lawlor DA, Batty GD, Kähönen M, Juonala M, Rönnemaa T, Viikari JSA, Lehtimäki T, Raitakari OT. Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study. Eur Heart J 2008;29:2552-2560. First published on June 10, 2008. doi:10.1093/ eurheartj/ehn252.
7. Bochud M, Chiolero A, Elston RC, Paccaud F. A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology. Int J Epidemiol 2008;37:414-416.
8. Davey Smith G, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 2004;33:30-42.
9. Nitsch D, Molokhia M, Smeeth L, DeStavola BL, Whittaker JC, Leon DA. Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials. Am J Epidemiol 2006;163:397-403.
10. Timpson NJ, Lawlor DA, Harbord RM, Gaunt TR, Day IN, Palmer LJ, Hattersley AT, Ebrahim S, Lowe GD, Rumley A, Davey SG. C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet 2005;366:1954-1959.
11. Davey SG, Lawlor DA, Harbord R, Timpson N, Rumley A, Lowe GD, Day IN, Ebrahim S. Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality. Arterioscler Thromb Vasc Biol 2005;25:1051-1056.
12. Kivimäki M, Lawlor DA, Eklund C, Smith GD, Hurme M, Lehtimaki T, Viikari JS, Raitakari OT. Mendelian randomization suggests no causal association between C-reactive protein and carotid intima-media thickness in the young Finns study. Arterioscler Thromb Vasc Biol 2007;27:978-979.
13. Casas JP, Shah T, Cooper J, Hawe E, McMahon AD, Gaffney D, Packard CJ, O'Reilly DS, Juhan-Vague I, Yudkin JS, Tremoli E, Margaglione M, Di MG, Hamsten A, Kooistra T, Stephens JW, Hurel SJ, Livingstone S, Colhoun HM, Miller GJ, Bautista LE, Meade T, Sattar N, Humphries SE, Hingorani AD. Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol 2006;35:922-931.