Phytochemical screening and hypoglycemic activity of carica papaya leaf in streptozotocin-induced diabetic rats

Revista Brasileira de Farmacognosia

Volumn 24, Issue 3, 2014, Pages 341-347

  Juárez Rojop, Isela E ^a   Tovilla Zárate, Carlos A ^a   Aguilar Domínguez, Dora E ^a   Fuente, Luis F Roa de la ^a   Lobato García, Carlos E ^a   Blé Castillo, Jorge L ^a   López Meraz, Leonor ^b   Díaz Zagoya, Juan C ^c   Bermúdez Ocaña, Deysi Y ^a  

^a UNIVERSIDAD JUÁREZ AUTÓNOMA DE TABASCO   (Mexico)

^b UNIVERSIDAD VERACRUZANA   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Alkaloids; Carica papaya; Diabetes; Quinones; Steroids; Streptozotocin; Tannins

Indexed keywords

EID: 84907334826     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bjp.2014.07.012     Document Type: Article

References (37)

1. Afrose, S., Hossain, M.S., Maki, T., Tsujii, H., 2009. Karaya root saponin exerts a hypocholesterolemic response in rats fed a high-cholesterol diet. Nutr. Res. 29, 350-354.
2. Ahmad, N., Fazal, H., Ayaz, M., Abbasi, B.H., Mohammad, I., Fazal, L., 2011. Dengue fever treatment with Carica papaya leaves extracts. Asian Pac. J. Trop. Biomed. 1, 330-333.
3. Akharaiyi, F.C., 2011. Antibacterial, phytochemical and antioxidant activities of Datura metel. Int. J. Pharm. Tech. Res. 3, 478-483.
4. Aruoma, O.I., Hayashi, Y., Marotta, F., Mantello, P., Rachmilewitz, E., Montagnier, L., 2010. Applications and bioefficacy of the functional food supplement fermented papaya preparation. Toxicology 278, 6-16.
5. Azarkan, M., Garcia-Pino, A., Dibiani, R., Wyns, L., Loris, R., Baeyens-Volant, D., 2006. Crystallization and preliminary X-ray analysis of a protease inhibitor from the latex of Carica papaya. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 62, 1239-1242.
6. Azuma, K., Toyofuku, Y., Iesaki, T., Otsuka, A., Tanaka, A., Mita, T., Hirose, T., Tanaka, Y., Daida, H., Kawamori, R., Watada, H., 2006. Acarbose, an alpha-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation. Biochem. Biophys. Res. Commun. 345, 688-693.
7. Barreto, M.C., 2005. Lipid extraction and cholesterol quantification-a simple protocol. J. J. Chem. Educ. 82, 103.
8. Canini, A., Alesiani, D., D'Arcangelo, G., Tagliatesta, P., 2007. Gas chromatography-mass spectrometry analysis of phenolic compounds from Carica papaya L. leaf. J. Food Compos. Anal. 20, 584-590.
9. Courteix, C., Bardin, M., Chantelauze, C., Lavarenne, J., Eschalier, A., 1994. Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics. Pain 57, 153-160.
10. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., Colotto, M., 2006. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin. Ter. 157, 195-198.
11. De D, Ali K.M., Chatterjee, K., Bera, T.K., Ghosh, D., 2012. Antihyperglycemic and antihyperlipidemic effects of n-hexane fraction from the hydro-methanolic extract of sepals of Salmalia malabarica in streptozotocin-induced diabetic rats. J. Complement. Integr. Med. 9, 1553-3840.
12. Fazel, S., Hamidreza, M., Rouhollah, G., Mohammadreza, V., 2008. Sprectrophotometric determination of total alkaloids in some Iranian medicinal plants. Thai J. Pharm. Sci. 32, 17-20.
13. FHEUM, 2001 Farmacopea Herbolaria de los Estados Unidos Mexicanos,. Secretaria de Salud. 10th ed. México.
14. Figueroa-Valverde, L., Díaz-Cedillo, F., López-Ramos, M., García-Cervera E, Pool-Gómez E, Cardena-Arredondo C, Ancona-Leon G. 2012. Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc. Czech. Repub. 156, 122-127.
15. Fraile, L., Crisci, E., Córdoba, L., Navarro, M.A., Osada, J., Montoya, M., 2012. Immunomodulatory properties of beta-sitosterol in pig immune responses. Int. Immunopharmacol. 13, 316-321.
16. Ghosh, D., Konishi, T., 2007. Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function. Asia Pac. J. Clin. Nutr. 16, 200-208.
17. Gupta, S., Kataria, M., Gupta, P.K., Murganandan, S., Yashroy, R.C., 2004. Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. J. Ethnopharmacol. 90, 185-189.
18. Hamden, K., Jaouadi, B., Zaraî, N., Rebai, T., Carreau, S., Elfeki, A., 2011. Inhibitory effects of estrogens on digestive enzymes, insulin deficiency, and pancreas toxicity in diabetic rats. J. Physiol. Biochem. 67, 121-128.
19. Head, W.F. Jr, Lauter, W.M., 1957. Ultrasonic depolymerization of natural polymers. J. Am. Pharm. Assoc. Am. Pharm. Assoc. 46, 617-621.
20. ISO, 1988. Sorghum: Determination of Tannin Content. ISO 9648, International Organization for Standardization.
21. Juárez-Rojop, I., Díaz-Zagoya, J.C., Ble-Castillo, J.L., Miranda-Osorio, P., Castell-Rodriguez, A.E., Tovilla-Zárate, C.A., Rodríguez-Hernández, A., Aguilar-Mariscal, H., Ramón-Frías, T., Bermúdez-Ocaña, D.Y., 2012. Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. BMC Comp. Alt. Med. 12, 236
22. Kesari, A.N., Gupta, R.K., Watal, G., 2005. Hypoglycemic effects of Murraya koenigii on normal and alloxan-diabetic rabbits. J. Ethnopharmacol. 97, 247-251.
23. Khuzhaev, V.U., Aripova, S.F., 2000. Pseudocarpaine from Carica papaya. Chem. Nat. Comp. 36, 418-420.
24. Koehn, F.E., Carter, G.T., 2005. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 4, 206-220.
25. Li, N., Xia, Q., Ruan, J., Fu, P.P., Lin, G., 2011. Hepatotoxicity and tumorigenicity induced by metabolic activation of pyrrolizidine alkaloids in herbs. Curr. Drug Metab. 12, 823-834.
26. Lim, T.K., 2012. Carica papaya. In: Edible Medicinal and Non-Medicinal Plants. Springer; 1:693-717.
27. Liu, S.Z., Deng, Y.X., Chen, B., Zhang, X.J., Shi, Q.Z., Qiu, X.M., 2013. Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats. J. Ethnopharmacol. 145, 490-498.
28. Miean, K.H., Mohamed, S., 2001. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J. Agric. Food Chem. 49, 3106-3112.
29. Owoyele, B.V., Adebukola, O.M., Funmilayo, A.A., Soladoye, A.O., 2008. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacol. 16, 168-173.
30. Pochapski, M.T., Fosquiera, E.C., Esmerino, L.A., Dos Santos, E.B., Farago, P.V., Santos, F.A., Groppo, F.C., 2011. Phytochemical screening, antioxidant, and antimicrobial activities of the crude leaves' extract from Ipomoea batatas (L.) Lam. Pharmacogn. Mag. 7, 165-170.
31. Polonsky, K.S., 2012. The past 200 years in diabetes. N. Engl. J. Med. 367, 1332-1340.
32. Robin, E.D., 1945. The reaction of vitamin A with Lieberman-Burchard reagent. Science 102, 17.
33. Sanders, R.A., Rauscher, F.M., Watkins, J.B., 2001. Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. J. Biochem. Mol. Toxicol. 15, 143-149.
34. Sasidharan, S., Sumathi, V., Jegathambigai, N.R., Latha, L.Y., 2011. Antihyperglycaemic effects of ethanol extracts of Carica papaya and Pandanus amaryfollius leaf in streptozotocininduced diabetic mice. Nat. Prod. Res. 20, 1982-1987.
35. Standl, E., Schnell, O., 2012. Alpha-glucosidase inhibitors: cardiovascular considerations and trial evaluation. Diab. Vasc. Dis. Res. 9, 163-169.
36. Trevisan, G., Rossato, M.F., Walker, C.I., Klafke, J.Z., Rosa, F., Oliveira, S.M., Tonello, R., Guerra, G.P., Boligon, A.A., Zanon, R.B., Athayde, M.L., Ferreira, J., 2012. Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J. Pharmacol. Exp. Ther. 343, 258-269.
37. WHO, 2012. Traditional medicine strategy: 2002-2005. World Health Organization press, p. 1-6.