Hepatotoxicity and tumorigenicity induced by metabolic activation of pyrrolizidine alkaloids in herbs

Current Drug Metabolism

Volumn 12, Issue 9, 2011, Pages 823-834

  Li, Na ^a   Xia, Qingsu ^b   Ruan, Jianqing ^a   Fu, Peter P ^b   Lin, Ge ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Hepatotoxicity; Herb drug interactions; Metabolic activation; Pyrrolizidine alkaloids; Tumorigenicity

Indexed keywords

5 (DEOXYGUANOSIN N 2 YL)DEHYDROSUPINIDINE; 7 HYDROXY 9 (DEOXYGUANOSIN N 2 YL)DEHYDROSUPINIDINE; CELL PROTEIN; CLIVORINE; CYTOCHROME P450; DNA; DRUG METABOLITE; DRUG METABOLIZING ENZYME; HELIOTRIDINE; HELIOTRINE; HERBACEOUS AGENT; HYDROXYSENKIRKINE; INTERMEDINE; JACOBINE; LASIOCARPINE; LYCOPSAMINE; MONOCROTALINE; OTONECINE; PETASITENINE; PLATYNECINE; PYRROLIZIDINE ALKALOID; RETRONECINE; RETRORSINE; RETRORSINE N OXIDE; RIDDELLINE; SENECIONINE; SENECIPHYLLINE; SENKIRKINE; SYMPHYTINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CARCINOGENICITY; CHINESE HERB; DEMETHYLATION; DNA ADDUCT; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; GENOTOXICITY; GEOGRAPHIC DISTRIBUTION; HERB DRUG INTERACTION; HERBAL MEDICINE; HUMAN; LIVER MICROSOME METABOLISM; LIVER TOXICITY; MEDICINAL PLANT; METABOLIC ACTIVATION; NONHUMAN; OXIDATION REDUCTION REACTION; POISONOUS PLANT; PROTEIN DNA INTERACTION; REVIEW; SPECIES DIFFERENCE;

EID: 80053530583     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920011797470119     Document Type: Review

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