Immunomodulatory properties of beta-sitosterol in pig immune responses

International Immunopharmacology

Volumn 13, Issue 3, 2012, Pages 316-321

  Fraile, Lorenzo ^a,b   Crisci, Elisa ^a   Córdoba, Lorena ^a   Navarro, María A ^c,d   Osada, Jesús ^c,d   Montoya, María ^a,e  

^a CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

^b UNIVERSITY OF LLEIDA   (Spain)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d Instituto de Salud Carlos III   (Spain)

^e IRTA   (Spain)

Author keywords

Immunomodulator; Phytosterols; PRRSV; Swine

Indexed keywords

APOLIPOPROTEIN A1; INMUNICIN MAYMO; PHYTOHEMAGGLUTININ; PORCILIS; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS MODIFIED LIFE VACCINE; SITOSTEROL; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTERIVIRUS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VACCINATION;

ANIMAL FEED; ANIMALS; APOLIPOPROTEIN A-I; DENDRITIC CELLS; FEMALE; IMMUNOLOGIC FACTORS; LEUKOCYTE COUNT; LYMPHOCYTE ACTIVATION; MALE; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SITOSTEROLS; SPAIN; SUS SCROFA; VIRAL VACCINES;

EID: 84861452311     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.04.017     Document Type: Article

References (38)

1. Blecha F. Immunomodulators for prevention and treatment of infectious diseases in food-producing animals. Vet Clin North Am Food Anim Pract 2001;17(3): 621-33 viii.
2. Hardy G. Nutraceuticals and functional foods: introduction and meaning. Nutrition 2000;16(7-8):688-9. (Pubitemid 30445151)
3. Kyriakis SC, Alexopoulos C, Giannakopoulos K, Tsinas AC, Saoulidis K, Kritas SK, et al. Effect of a paramunity inducer on reproductive performance of gilts. Zentralbl Veterinarmed A 1996;43(8):483-7. (Pubitemid 126475050)
4. Kyriakis SC, Tzika ED, Lyras DN, Tsinas AC, Saoulidis K, Sarris K. Effect of an inactivated Parapoxvirus based immunomodulator (Baypamun) on post weaning diarrhoea syndrome and wasting pig syndrome of piglets. Res Vet Sci 1998;64(3): 187-90. (Pubitemid 128518967)
5. Fachinger V, Schlapp T, Strube W, Schmeer N, Saalmuller A. Poxvirus-induced immunostimulating effects on porcine leukocytes. J Virol 2000;74(17):7943-51. (Pubitemid 30641638)
6. Bouic PJ. The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years. Curr Opin Clin Nutr Metab Care 2001;4(6):471-5. (Pubitemid 34755401)
7. Bouic PJ, Clark A, Brittle W, Lamprecht JH, Freestone M, Liebenberg RW. Plant sterol/sterolin supplement use in a cohort of South AfricanHIV-infected patients - effects on immunological and virological surrogatemarkers. S AfrMed J 2001;91(10): 848-50. (Pubitemid 33062313)
8. Breytenbach U, Clark A, Lamprecht J, Bouic P. Flow cytometric analysis of the Th1-Th2 balance in healthy individuals and patients infected with the human immunodeficiency virus (HIV) receiving a plant sterol/sterolin mixture. Cell Biol Int 2001;25(1):43-9. (Pubitemid 32113486)
9. Mateu E, Diaz I. The challenge of PRRS immunology. Vet J 2008;177(3):345-51. (Pubitemid 351899463)
10. Petersen HH, Nielsen JP, Heegaard PM. Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res 2004;35:163-87. (Pubitemid 38559106)
11. Cabana VG, Lukens JR, Rice KS, Hawkins TJ, Getz GS. HDL content and composition in acute phase response in three species: triglyceride enrichment of HDL a factor in its decrease. J Lipid Res 1996;37(12):2662-74.
12. Lindhorst E, Young D, Bagshaw W, Hyland M, Kisilevsky R. Acute inflammation, acute phase serum amyloid A and cholesterol metabolism in the mouse. Biochim Biophys Acta 1997;1339(1):143-54. (Pubitemid 27193322)
13. Burger D, Dayer JM. High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation? Autoimmun Rev 2002;1(1-2):111-7. (Pubitemid 38367434)
14. Summerfield A, McCullough KC. Porcine bone marrow myeloid cells: phenotype and adhesion molecule expression. J Leukoc Biol 1997;62(2):176-85. (Pubitemid 27380789)
15. Kekarainen T, Montoya M, Dominguez J, Mateu E, Segales J. Porcine circovirus type 2 (PCV2) viral components immunomodulate recall antigen responses. Vet Immunol Immunopathol 2008;124(1-2):41-9.
16. Mussá T, Rodriguez-Cariño C, Pujol M, Córdoba L, Busquets N, Crisci E, et al. Interaction of porcine conventional dendritic cells with swine influenza virus. Virology 2011;420(2):125-3417.
17. Domeika K, Magnusson M, Eloranta ML, Fuxler L, Alm GV, Fossum C. Characteristics of oligodeoxyribonucleotides that induce interferon (IFN)-alpha in the pig and the phenotype of the IFN-alpha producing cells. Vet Immunol Immunopathol 2004;101(1-2):87-102. (Pubitemid 38903109)
18. Guzylack-Piriou L, Balmelli C, McCullough KC, Summerfield A. Type-A CpG oligonucleotides activate exclusively porcine natural interferon-producing cells to secrete interferon-alpha, tumour necrosis factor-alpha and interleukin-12. Immunology 2004;112(1):28-37. (Pubitemid 38609819)
19. Mateu E, Martín M, Vidal D. Genetic diversity and phylogenetic analysis of glycoprotein 5 of European-type porcine reproductive and respiratory virus strains in Spain. J Gen Virol 2003;84:529-34. (Pubitemid 36267124)
20. Subcommittee on swine nutrition, Committee on Animal Nutrition, National Research Council. Nutrient Requirements of Swine. 10th rev ed. Washington, DC: National Academy Press; 1998. Available at: http://www.nap.edu/openbook.php? record-id=6016&page=31. Accessed 19 October 2011.
21. Navarro MA, Carpintero R, Acin S, Arbones-Mainar JM, Calleja L, Carnicer R, et al. Immune-regulation of the apolipoprotein A-I/C-III/A-IV gene cluster in experimental inflammation. Cytokine 2005;31:52-63. (Pubitemid 40828359)
22. Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 2006;311:17-58. (Pubitemid 47413194)
23. Lokshin AE, Kalinski P, Sassi RR, Mailliard RB, Müller-Berghaus J, Storkus WJ, et al. Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II. Int Immunol 2002;14(9):1027-37.
24. Desai F, Ramanathan M, Fink CS, Wilding GE, Weinstock-Guttman B, Awad AB. Comparison of the immunomodulatory effects of the plant sterol beta-sitosterol to simvastatin in peripheral blood cells from multiple sclerosis patients. Int Immunopharmacol 2009;9(1):153-7.
25. Ling WH, Jones PJ. Dietary phytosterols: a review of metabolism, benefits and side effects. Life Sci 1995;57(3):195-206.
26. Summerfield A, McCullough KC. The porcine dendritic cell family. Dev Comp Immunol 2009;33(3):299-309.
27. Cao S, Li Y, Ye J, Yang X, Chen L, Liu X, et al. Japanese encephalitis Virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells. Virol J 2011;26(8):39.
28. Faisal SM, Chen JW, McDonough SP, Chang CF, Teng CH, Chang YF. Immunostimulatory and antigen delivery properties of liposomes made up of total polar lipids from non-pathogenic bacteria leads to efficient induction of both innate and adaptive immune responses. Vaccine 2011;29(13):2381-91.
29. Yuk JE,Woo JS, Yun CY, Lee JS, KimJH, Song GY, et al. Effects of lactose-beta-sitosterol and beta-sitosterol on ovalbumin-induced lung inflammation in actively sensitized mice. Int Immunopharmacol 2007;7(12):1517-27. (Pubitemid 47500223)
30. Kay AB. Allergy and allergic diseases. Second of two parts. N Engl J Med 2001;344(2):109-13. (Pubitemid 32052501)
31. Lee JH, Lee JY, Park JH, Jung HS, Kim JS, Kang SS, et al. Immunoregulatory activity by daucosterol, a beta-sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice. Vaccine 2007;25(19):3834-40. (Pubitemid 46589752)
32. Brüll F, Mensink RP, van den Hurk K, Duijvestijn A, Plat J. TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols. J Biol Chem 2010;285(5):2951-8.
33. Royaee AR, Husmann RJ, Dawson HD, Calzada-Nova G, Schnitzlein WM, Zuckermann FA, et al. Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination. Vet Immunol Immunopathol 2004;102(3):199-216. (Pubitemid 39422645)
34. Albina E, Piriou L, Hutet E, Cariolet R, L'Hospitalier R. Immune responses in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). Vet Immunol Immunopathol 1998;61(1):49-66. (Pubitemid 28206884)
35. Summerfield A, Guzylack-Piriou L, Schaub A, Carrasco CP, Tache V, Charley B, et al. Porcine peripheral blood dendritic cells and natural interferon-producing cells. Immunology 2003;110(4):440-9. (Pubitemid 37521874)
36. Pays E, Vanhollebeke B. Human innate immunity against African trypanosomes. Curr Opin Immunol 2009;21:493-8.
37. Heegaard PM, Stockmarr A, Piñeiro M, Carpintero R, Lampreave F, Campbell FM, et al. Optimal combinations of acute phase proteins for detecting infectious disease in pigs. Vet Res 2011;42:50.
38. Zuckermann FA, Garcia EA, Luque ID, Christopher-Hennings J, Doster A, Brito M, et al. Assessment of the efficacy of commercial porcine reproductive and respiratory syndrome virus (PRRSV) vaccines based on measurement of serologic response, frequency of gamma-IFN-producing cells and virological parameters of protection upon challenge. Vet Microbiol 2007;123(1-3):69-85. (Pubitemid 46898707)