Acarbose, an α-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation

Biochemical and Biophysical Research Communications

Volumn 345, Issue 2, 2006, Pages 688-693

  Azuma, Kosuke ^a   Toyofuku, Yukiko ^a   Iesaki, Takafumi ^a   Otsuka, Aiko ^a   Tanaka, Atsuko ^a   Mita, Tomoya ^a   Hirose, Takahisa ^a   Tanaka, Yasushi ^a   Daida, Hiroyuki ^a   Kawamori, Ryuzo ^a   Watada, Hirotaka ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

Cardiovascular disease; Endothelial dysfunction; Postprandial hyperglycemia; Type 2 diabetes mellitus

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; CHOLESTEROL; FATTY ACID; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CARDIOVASCULAR DISEASE; CELL ADHESION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INFORMATION PROCESSING; INSULIN BLOOD LEVEL; MALE; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; VASODILATATION;

ACARBOSE; ACETYLCHOLINE; ANIMALS; AORTA; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; MODELS, ANIMAL; POSTPRANDIAL PERIOD; RATS; TIME FACTORS; TUNICA INTIMA;

EID: 33646844459     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.04.090     Document Type: Article

References (16)

1. Wild S., Roglic G., Green A., Sicree R., and King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27 (2004) 1047-1053
2. Haffner S.M., Lehto S., Ronnemaa T., Pyorala K., and Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N. Engl. J. Med. 339 (1998) 229-234
3. Rodriguez B.L., Lau N., Burchfiel C.M., Abbott R.D., Sharp D.S., Yano K., and Curb J.D. Glucose intolerance and 23-year risk of coronary heart disease and total mortality: the Honolulu Heart Program. Diabetes Care 22 (1999) 1262-1265
4. Coutinho M., Gerstein H.C., Wang Y., and Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care 22 (1999) 233-240
5. The DECODE study group on behalf of the European Diabetes Epidemiology Group, Glucose tolerance and mortality: comparison of WHO and American Diabetic Association diagnostic criteria. Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe, Lancet 354 (1999) 617-621.
6. Nakagami T. Hyperglycaemia and mortality from all causes and from cardiovascular disease in five populations of Asian origin. Diabetologia 47 (2004) 385-394
7. Ogawa S., Takeuchi K., and Ito S. Acarbose lowers serum triglyceride and postprandial chylomicron levels in type 2 diabetes. Diabetes Obes. Metab. 6 (2004) 384-390
8. Reaven G.M., Lardinois C.K., Greenfield M.S., Schwartz H.C., and Vreman H.J. Effect of acarbose on carbohydrate and lipid metabolism in NIDDM patients poorly controlled by sulfonylureas. Diabetes Care 13 Suppl. 3 (1990) 32-36
9. Chiasson J.L., Josse R.G., Gomis R., Hanefeld M., Karasik A., and Laakso M. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290 (2003) 486-494
10. Hanefeld M., Cagatay M., Petrowitsch T., Neuser D., Petzinna D., and Rupp M. Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies. Eur. Heart J. 25 (2004) 10-16
11. Azuma K., Watada H., Niihashi M., Otsuka A., Sato F., Kawasumi M., Shimada S., Tanaka Y., Kawamori R., and Mitsumata M. A new En face method is useful to quantitate endothelial damage in vivo. Biochem. Biophys. Res. Commun. 309 (2003) 384-390
12. Otsuka A., Azuma K., Iesaki T., Sato F., Hirose T., Shimizu T., Tanaka Y., Daida H., Kawamori R., and Watada H. Temporary hyperglycaemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta. Diabetologia 48 (2005) 2667-2674
13. Goto Y., Suzuki K., Sasaki M., Ono T., and Abe S. GK rats as a model of non-obese, non-insulin dependent diabetes: selective breeding over 35 generations. In: Shafrir E., and Reynold A.E. (Eds). In Lessons from Animal Diabetes II (1998), Libbey, London 301-303
14. Azuma K., Watada H., Otsuka A., Sato F., Tanaka T., Hirose T., and Kawamori R. Repetitive glucose spike enhances monocyte adhesion to endothelial cells more than consistent hyperglycemia in rat thoracic artery. Diabetes 54 Suppl. 1 (2005) A188
15. 2. Am. J. Physiol. 277 (1999) H978-H985
16. Rebolledo O.R., and Actis Dato S.M. Postprandial hyperglycemia and hyperlipidemia-generated glycoxidative stress: its contribution to the pathogenesis of diabetes complications. Eur. Rev. Med. Pharmacol. Sci. 9 (2005) 191-208