ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion

Biochemical and Biophysical Research Communications

Volumn 409, Issue 1, 2011, Pages 96-102

  Naji, Latifa ^a   Pacholsky, Dirk ^b   Aspenström, Pontus ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Actin dynamics; Rho; RhoGAP; Wrch 1

Indexed keywords

ACTIN; PROTEIN ARHGAP30; PROTEIN CDC42; PROTEIN WRCH 1; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; WRCH 1 INTERACTING PROTEIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; FOCAL ADHESION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; STRESS FIBER; TIGHT JUNCTION;

ACTINS; ANIMALS; CELL ADHESION; CELLS, CULTURED; GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; MICE; PHYLOGENY; RHO GTP-BINDING PROTEINS; SWINE;

EID: 79956193597     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.04.116     Document Type: Article

References (15)

1. Jaffe A.B., Hall A. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 2005, 21:247-269.
2. Tao W., Pennica D., Xu L., Kalejata R.F., Levine A.J. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Develop. 2001, 15:1796-1807.
3. Saras J., Wollberg P., Aspenström P. Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects. Exp. Cell Res. 2004, 299:356-369.
4. Shutes A., Berzat A.C., Cox A.D., Der C.J. Atypical mechanisms of regulation of the Wrch-1 Rho family small GTPase. Curr. Biol. 2004, 14:2052-2056.
5. Aspenström P., Fransson Å., Saras J. Rho GTPases have diverse effects on the organization of the actin filament system. Biochem. J. 2004, 377:327-337.
6. Chenette E.J., Abo A., Der C.J. Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. J. Biol. Chem. 2005, 280:13784-13792.
7. Berzat A.C., Buss J.E., Chenette E.J., Weinbaum C.A., Shutes A., Der C.J., Minden A., Cox A.D. Transforming activity of the Rho family GTPase Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. J. Biol. Chem. 2005, 280:33055-33065.
8. Chuang Y.Y., Valster A., Coniglio S.J., Backer J.M., Symons M. The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration. J. Cell Sci. 2007, 120:1927-1934.
9. Brady D.C., Alan J.K., Madigan J.P., Fanning A.S., Cox A.D. The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Mol. Cell. Biol. 2009, 29:1035-1049.
10. Ruusala A., Aspenström P. The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. Mol. Cell. Biol. 2008, 28:1802-1814.
11. Lamarche-Vane N., Hall A. CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. J. Biol. Chem. 1998, 273:29172-29177.
12. Richnau N., Aspenström P. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. J. Biol. Chem. 2001, 276:35060-35070.
13. Self A.J., Hall A. Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates. Methods Enzymol. 1995, 256:67-76.
14. Fackler O.T., Grosse R. Cell motility through plasma membrane blebbing. J. Cell Biol. 2008, 879:879-884.
15. Primeau M., Ben Djoudi Ouadda A., Lamarche-Vane N. Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of intersectin through a novel basic-rich motif. FEBS Lett. 2011, 585:847-853.