MiR-124a restoration inhibits glioma cell proliferation and invasion by suppressing IQGAP1 and β-catenin

Oncology Reports

Volumn 32, Issue 5, 2014, Pages 2104-2110

  Lu, Shao Hua ^a   Jiang, Xing Jun ^a   Xiao, Ge Lei ^a   Liu, Ding Yang ^a   Yuan, Xian Rui ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Invasion; IQGAP1; MiR 124a; Proliferation; catenin

Indexed keywords

ACTIN; BETA CATENIN; CYCLIN D1; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MICRORNA; MICRORNA 124A; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MIRN124 MICRORNA, HUMAN;

ARTICLE; CANCER GRADING; CANCER INHIBITION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GLIOMA CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IQGAP1 GENE; MOLECULAR DYNAMICS; PROTEIN RNA BINDING; PROTEIN TARGETING; RNA INTERFERENCE; TUMOR INVASION; GENE SILENCING; GENETICS; GLIOMA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

BETA CATENIN; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GLIOMA; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; RAS GTPASE-ACTIVATING PROTEINS;

EID: 84907289380     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3455     Document Type: Article

References (32)

1. Dolecek TA, Propp JM, Stroup NE and Kruchko C: CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol 14 (Suppl 5): v1-v49, 2012.
2. Louis DN, Ohgaki H, Wiestler OD, et al: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114: 97-109, 2007.
3. Volinia S, Calin GA, Liu CG, et al: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103: 2257-2261, 2006.
4. Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
5. Hammond SM: MicroRNAs as oncogenes. Curr Opin Genet Dev 16: 4-9, 2006.
6. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W and Tuschl T: Identification of tissue-specific microRNAs from mouse. Curr Biol 12: 735-739, 2002.
7. An L, Liu Y, Wu A and Guan Y: microRNA-124 inhibits migration and invasion by down-regulating ROCK1 in glioma. PLoS One 8: e69478, 2013.
8. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
9. Li Q, Bian S, Hong J, et al: Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development. PLoS One 6: e26000, 2011.
10. Chen CZ, Li L, Lodish HF and Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83-86, 2004.
11. Brennecke J, Hipfner DR, Stark A, Russell RB and Cohen SM: bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113: 25-36, 2003.
12. Chen CH, Guo M and Hay BA: Identifying microRNA regulators of cell death in Drosophila. Methods Mol Biol 342: 229-240, 2006.
13. Fu LL, Wen X, Bao JK and Liu B: MicroRNA-modulated autophagic signaling networks in cancer. Int J Biochem Cell Biol 44: 733-736, 2012.
14. Ambros V: The functions of animal microRNAs. Nature 431: 350-355, 2004.
15. Medina PP and Slack FJ: microRNAs and cancer: an overview. Cell Cycle 7: 2485-2492, 2008.
16. Xia J, Wu Z, Yu C, et al: miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1. J Pathol 227: 470-480, 2012.
17. Lang Q and Ling C: MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. Biochem Biophys Res Commun 426: 247-252, 2012.
18. Lv XB, Jiao Y, Qing Y, et al: miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro. Chin J Cancer 30: 821-830, 2011.
19. Cao X, Pfaff SL and Gage FH: A functional study of miR-124 in the developing neural tube. Genes Dev 21: 531-536, 2007.
20. Cheng LC, Pastrana E, Tavazoie M and Doetsch F: miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci 12: 399-408, 2009.
21. Watanabe T, Wang S, Noritake J, et al: Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 7: 871-883, 2004.
22. Mataraza JM, Briggs MW, Li Z, Entwistle A, Ridley AJ and Sacks DB: IQGAP1 promotes cell motility and invasion. J Biol Chem 278: 41237-41245, 2003.
23. Nieto MA: The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3: 155-166, 2002.
24. Nabeshima K, Shimao Y, Inoue T and Koono M: Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. Cancer Lett 176: 101-109, 2002.
25. Dong P, Nabeshima K, Nishimura N, Kawakami T, Hachisuga T, Kawarabayashi T and Iwasaki H: Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas. Cancer Lett 243: 120-127, 2006.
26. Balenci L, Clarke ID, Dirks PB, et al: IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme. Cancer Res 66: 9074-9082, 2006.
27. Johnson M, Sharma M and Henderson BR: IQGAP1 regulation and roles in cancer. Cell Signal 21: 1471-1478, 2009.
28. Nakamura H, Fujita K, Nakagawa H, Kishi F, Takeuchi A, Aute I and Kato H: Expression pattern of the scaffold protein IQGAP1 in lung cancer. Oncol Rep 13: 427-431, 2005.
29. Kuroda S, Fukata M, Nakagawa M, et al: Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science 281: 832-835, 1998.
30. Polakis P: Wnt signaling and cancer. Genes Dev 14: 1837-1851, 2000.
31. Breuhahn K, Longerich T and Schirmacher P: Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 25: 3787-3800, 2006.
32. Lee HC, Kim M and Wands JR: Wnt/Frizzled signaling in hepatocellular carcinoma. Front Biosci 11: 1901-1915, 2006.