-
1
-
-
33748041958
-
Effects of protein aggregates: an immunologic perspective
-
Rosenberg A.S. Effects of protein aggregates: an immunologic perspective. AAPS J. 2006, 8:E501-E507.
-
(2006)
AAPS J.
, vol.8
-
-
Rosenberg, A.S.1
-
2
-
-
0027729733
-
The development of stable protein formulations - a close look at protein aggregation, deamidation, and oxidation
-
Cleland J.L., Powell M.F., Shire S.J. The development of stable protein formulations - a close look at protein aggregation, deamidation, and oxidation. Crit. Rev. Therap. Drug Carr. Syst. 1993, 10:307-377.
-
(1993)
Crit. Rev. Therap. Drug Carr. Syst.
, vol.10
, pp. 307-377
-
-
Cleland, J.L.1
Powell, M.F.2
Shire, S.J.3
-
3
-
-
0021772650
-
Kinetics of unfolding of proteins on hydrophobic surfaces in reversed-phase liquid-chromatography
-
Benedek K., Dong S., Karger B.L. Kinetics of unfolding of proteins on hydrophobic surfaces in reversed-phase liquid-chromatography. J. Chromatogr. 1984, 317:227-243.
-
(1984)
J. Chromatogr.
, vol.317
, pp. 227-243
-
-
Benedek, K.1
Dong, S.2
Karger, B.L.3
-
4
-
-
0022556341
-
Conformational effects in the high-performance liquid-chromatography of proteins - further-studies of the reversed-phase chromatographic behavior of ribonuclease-a
-
Lu X.M., Benedek K., Karger B.L. Conformational effects in the high-performance liquid-chromatography of proteins - further-studies of the reversed-phase chromatographic behavior of ribonuclease-a. J. Chromatogr. 1986, 359:19-29.
-
(1986)
J. Chromatogr.
, vol.359
, pp. 19-29
-
-
Lu, X.M.1
Benedek, K.2
Karger, B.L.3
-
5
-
-
0011981081
-
The effect of on-column structural-changes of proteins on their hplc behavior
-
Karger B.L., Blanco R. The effect of on-column structural-changes of proteins on their hplc behavior. Talanta 1989, 36:243-248.
-
(1989)
Talanta
, vol.36
, pp. 243-248
-
-
Karger, B.L.1
Blanco, R.2
-
6
-
-
0023057724
-
Protein conformational effects in hydrophobic interaction chromatography - retention characterization and the role of mobile phase additives and stationary phase hydrophobicity
-
Wu A.-L., Figueroa A., Karger B.L. Protein conformational effects in hydrophobic interaction chromatography - retention characterization and the role of mobile phase additives and stationary phase hydrophobicity. J. Chromatogr. 1986, 371:3-27.
-
(1986)
J. Chromatogr.
, vol.371
, pp. 3-27
-
-
Wu, A.-L.1
Figueroa, A.2
Karger, B.L.3
-
7
-
-
20444483268
-
Hydrophobic interaction chromatography of proteins - III. Unfolding of proteins upon adsorption
-
Jungbauer A., Machold C., Hahn R. Hydrophobic interaction chromatography of proteins - III. Unfolding of proteins upon adsorption. J. Chromatogr. A 2005, 1079:221-228.
-
(2005)
J. Chromatogr. A
, vol.1079
, pp. 221-228
-
-
Jungbauer, A.1
Machold, C.2
Hahn, R.3
-
8
-
-
84864052659
-
Cation exchange surface-mediated denaturation of an aglycosylated immunoglobulin (IgG1)
-
Gillespie R., Nguyen T., Macneil S., Jones L., Crampton S., Vunnum S. Cation exchange surface-mediated denaturation of an aglycosylated immunoglobulin (IgG1). J. Chromatogr. A 2012, 1251:101-110.
-
(2012)
J. Chromatogr. A
, vol.1251
, pp. 101-110
-
-
Gillespie, R.1
Nguyen, T.2
Macneil, S.3
Jones, L.4
Crampton, S.5
Vunnum, S.6
-
9
-
-
84904757929
-
Unfolding and aggregation of a glycosylated monoclonal antibody on a cation exchange column. Part I. Chromatographic elution and batch adsorption behavior
-
Guo J., Zhang S., Carta G. Unfolding and aggregation of a glycosylated monoclonal antibody on a cation exchange column. Part I. Chromatographic elution and batch adsorption behavior. J. Cromatogr. A 2014, 1356:117-128.
-
(2014)
J. Cromatogr. A
, vol.1356
, pp. 117-128
-
-
Guo, J.1
Zhang, S.2
Carta, G.3
-
10
-
-
84860805088
-
Fragmentation hydrogen exchange mass spectrometry: A review of methodology and applications
-
Brock A. Fragmentation hydrogen exchange mass spectrometry: A review of methodology and applications. Protein Expr. Purif. 2012, 84:19-37.
-
(2012)
Protein Expr. Purif.
, vol.84
, pp. 19-37
-
-
Brock, A.1
-
11
-
-
84863207545
-
Hydrogen exchange mass spectrometry: are we out of the quicksand?
-
Iacob R.E., Engen J.R. Hydrogen exchange mass spectrometry: are we out of the quicksand?. J. Am. Soc. Mass Spectrom. 2012, 23:1003-1010.
-
(2012)
J. Am. Soc. Mass Spectrom.
, vol.23
, pp. 1003-1010
-
-
Iacob, R.E.1
Engen, J.R.2
-
12
-
-
64849114588
-
Characterization of igg1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry
-
Houde D., Arndt J., Domeier W., Berkowitz S., Engen J.R. Characterization of igg1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal. Chem. 2009, 81:2644-2651.
-
(2009)
Anal. Chem.
, vol.81
, pp. 2644-2651
-
-
Houde, D.1
Arndt, J.2
Domeier, W.3
Berkowitz, S.4
Engen, J.R.5
-
13
-
-
77950236865
-
Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry
-
Burkitt W., Domann P., O'Connor G. Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry. Protein Sci. 2010, 19:826-835.
-
(2010)
Protein Sci.
, vol.19
, pp. 826-835
-
-
Burkitt, W.1
Domann, P.2
O'Connor, G.3
-
14
-
-
84860581906
-
Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange
-
Zhang A., Singh S.K., Shirts M.R., Kumar S., Fernandez E.J. Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange. Pharm. Res. 2012, 29:236-250.
-
(2012)
Pharm. Res.
, vol.29
, pp. 236-250
-
-
Zhang, A.1
Singh, S.K.2
Shirts, M.R.3
Kumar, S.4
Fernandez, E.J.5
-
15
-
-
84877787093
-
Effects of salts from the hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an igg1 monoclonal antibody
-
Majumdar R., Manikwar P., Hickey J.M., Samra H.S., Sathish H.A., Bishop S.M., Middaugh C.R., Weis D.D., Volkin D.B. Effects of salts from the hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an igg1 monoclonal antibody. Biochemistry 2013, 52:3376-3389.
-
(2013)
Biochemistry
, vol.52
, pp. 3376-3389
-
-
Majumdar, R.1
Manikwar, P.2
Hickey, J.M.3
Samra, H.S.4
Sathish, H.A.5
Bishop, S.M.6
Middaugh, C.R.7
Weis, D.D.8
Volkin, D.B.9
-
16
-
-
84879009285
-
Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry
-
Manikwar P., Majumdar R., Hickey J.M., Thakkar S.V., Samra H.S., Sathish H.A., Bishop S.M., Middaugh C.R., Weis D.D., Volkin D.B. Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry. J. Pharm. Sci. 2013, 102:2136-2151.
-
(2013)
J. Pharm. Sci.
, vol.102
, pp. 2136-2151
-
-
Manikwar, P.1
Majumdar, R.2
Hickey, J.M.3
Thakkar, S.V.4
Samra, H.S.5
Sathish, H.A.6
Bishop, S.M.7
Middaugh, C.R.8
Weis, D.D.9
Volkin, D.B.10
-
17
-
-
33744455465
-
Amide hydrogen-deuterium exchange: A fast tool for screening protein stabilities in chromatography
-
Fogle J.L., Fernandez E.J. Amide hydrogen-deuterium exchange: A fast tool for screening protein stabilities in chromatography. LC-GC North Am. 2006, 24:96-101.
-
(2006)
LC-GC North Am.
, vol.24
, pp. 96-101
-
-
Fogle, J.L.1
Fernandez, E.J.2
-
18
-
-
0037342549
-
Alpha-Lactalbumin tertiary structure changes on hydrophobic interaction chromatography surfaces
-
Jones T.T., Fernandez E.J. alpha-Lactalbumin tertiary structure changes on hydrophobic interaction chromatography surfaces. J. Colloid Interface Sci. 2003, 259:27-35.
-
(2003)
J. Colloid Interface Sci.
, vol.259
, pp. 27-35
-
-
Jones, T.T.1
Fernandez, E.J.2
-
19
-
-
33745266718
-
Loading, stationary phase, and salt effects during hydrophobic interaction chromatography: alpha-Lactalbumin is stabilized at high loadings
-
Fogle J.L., O'Connell J.P., Fernandez E.J. Loading, stationary phase, and salt effects during hydrophobic interaction chromatography: alpha-Lactalbumin is stabilized at high loadings. J. Chromatogr. A 2006, 1121:209-218.
-
(2006)
J. Chromatogr. A
, vol.1121
, pp. 209-218
-
-
Fogle, J.L.1
O'Connell, J.P.2
Fernandez, E.J.3
-
20
-
-
33845920377
-
Protein instability during HIC: Hydrogen exchange labeling analysis and a framework for describing mobile and stationary phase effects
-
Xiao Y., Jones T.T., Laurent A.H., O'Connell J.P., Przybycien T.M., Fernandez E.J. Protein instability during HIC: Hydrogen exchange labeling analysis and a framework for describing mobile and stationary phase effects. Biotechnol. Bioeng. 2007, 96:80-93.
-
(2007)
Biotechnol. Bioeng.
, vol.96
, pp. 80-93
-
-
Xiao, Y.1
Jones, T.T.2
Laurent, A.H.3
O'Connell, J.P.4
Przybycien, T.M.5
Fernandez, E.J.6
-
21
-
-
77955428025
-
Changes in solvent exposure reveal the kinetics and equilibria of adsorbed protein unfolding in hydrophobic interaction chromatography
-
Deitcher R.W., O'Connell J.P., Fernandez E.J. Changes in solvent exposure reveal the kinetics and equilibria of adsorbed protein unfolding in hydrophobic interaction chromatography. J. Chromatogr. A 2010, 1217:5571-5583.
-
(2010)
J. Chromatogr. A
, vol.1217
, pp. 5571-5583
-
-
Deitcher, R.W.1
O'Connell, J.P.2
Fernandez, E.J.3
-
22
-
-
78650693369
-
Protein stability and structure in HIC: hydrogen exchange experiments and COREX calculations
-
Gospodarek A.M., Smatlak M.E., O'Connell J.P., Fernandez E.J. Protein stability and structure in HIC: hydrogen exchange experiments and COREX calculations. Langmuir 2011, 27:286-295.
-
(2011)
Langmuir
, vol.27
, pp. 286-295
-
-
Gospodarek, A.M.1
Smatlak, M.E.2
O'Connell, J.P.3
Fernandez, E.J.4
-
23
-
-
0027250665
-
Primary structure effects on peptide group hydrogen-exchange
-
Bai Y., Milne J.S., Mayne L., Englander S.W. Primary structure effects on peptide group hydrogen-exchange. Proteins 1993, 17:75-86.
-
(1993)
Proteins
, vol.17
, pp. 75-86
-
-
Bai, Y.1
Milne, J.S.2
Mayne, L.3
Englander, S.W.4
-
24
-
-
0036463721
-
Hydrogen exchange-mass spectrometry: optimization of digestion conditions
-
Wang L., Pan H., Smith D.L. Hydrogen exchange-mass spectrometry: optimization of digestion conditions. Mol. Cell. Proteomics 2002, 1:132-138.
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 132-138
-
-
Wang, L.1
Pan, H.2
Smith, D.L.3
-
25
-
-
0028920695
-
Fecognition sites on human-IgG for Fc-gamma receptors - the role of glycosylation
-
Jefferis R., Lund J., Goodall M. Fecognition sites on human-IgG for Fc-gamma receptors - the role of glycosylation. Immunol. Lett. 1995, 44:111-117.
-
(1995)
Immunol. Lett.
, vol.44
, pp. 111-117
-
-
Jefferis, R.1
Lund, J.2
Goodall, M.3
-
26
-
-
33847059215
-
Effects of acid exposure on the conformation, stability, and aggregation of monoclonal antibodies
-
Ejima D., Tsumoto K., Fukada H., Yumioka R., Nagase K., Arakawa T., Philo J.S. Effects of acid exposure on the conformation, stability, and aggregation of monoclonal antibodies. Prot. Struct. Func. Bioinf. 2007, 66:954-962.
-
(2007)
Prot. Struct. Func. Bioinf.
, vol.66
, pp. 954-962
-
-
Ejima, D.1
Tsumoto, K.2
Fukada, H.3
Yumioka, R.4
Nagase, K.5
Arakawa, T.6
Philo, J.S.7
-
27
-
-
0025837548
-
Alternatively folded states of an immunoglobulin
-
Buchner J., Renner M., Lilie H., Hinz H.J., Jaenicke R., Kiefhabel T., Rudolph R. Alternatively folded states of an immunoglobulin. Biochem. 1991, 30:6922-6929.
-
(1991)
Biochem.
, vol.30
, pp. 6922-6929
-
-
Buchner, J.1
Renner, M.2
Lilie, H.3
Hinz, H.J.4
Jaenicke, R.5
Kiefhabel, T.6
Rudolph, R.7
-
28
-
-
0034076282
-
The thermal stability of immunoglobulin: Unfolding and aggregation of a multi-domain protein
-
Vermeer A.W.P., Norde W. The thermal stability of immunoglobulin: Unfolding and aggregation of a multi-domain protein. Biophys. J. 2000, 78:394-404.
-
(2000)
Biophys. J.
, vol.78
, pp. 394-404
-
-
Vermeer, A.W.P.1
Norde, W.2
|