Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: Potential role of EMT

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Buhrmann, Constanze ^a   Kraehe, Patricia ^a   Lueders, Cora ^b   Shayan, Parviz ^c,d   Goel, Ajay ^e   Shakibaei, Mehdi ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^c Investigating Institute of Molecular Biological System Transfer   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; BETA1 INTEGRIN; CD133 ANTIGEN; COLLAGENASE 3; CURCUMIN; CYCLIN D1; FLUOROURACIL; HERMES ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; KI 67 ANTIGEN; SMAD2 PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; TRANSFORMING GROWTH FACTOR BETA3; UVOMORULIN; VIMENTIN; TRANSFORMING GROWTH FACTOR BETA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER STEM CELL; CELL ADHESION; CELL DENSITY; CELL PROLIFERATION; CELL SURVIVAL; CHEMOSENSITIZATION; COCULTURE; COLON CANCER; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; EPITHELIAL MESENCHYMAL TRANSITION; FEEDBACK SYSTEM; FIBROBLAST; HCT116 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOLECULAR INTERACTION; MONOLAYER CULTURE; MONOTHERAPY; PROTEIN EXPRESSION; STROMA CELL; STROMAL FIBROBLAST; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION; COLON TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

COCULTURE TECHNIQUES; COLONIC NEOPLASMS; CURCUMIN; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROBLASTS; FLUOROURACIL; HCT116 CELLS; HUMANS; SIGNAL TRANSDUCTION; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA; TUMOR MICROENVIRONMENT;

EID: 84907267763     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107514     Document Type: Article

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