UDP-N-acetylmuramic acid L-alanine ligase (MurC) inhibition in a tolC mutant Escherichia coli strain leads to cell death

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 10, 2014, Pages 6165-6171

  Humnabadkar, Vaishali ^a   Prabhakar, K R ^a   Narayan, Ashwini ^a   Sharma, Sreevalli ^a   Guptha, Supreeth ^a   Manjrekar, Praveena ^a   Chinnaoattu, Muruaan ^a   Ramachandran, Vasanthi ^a   Hameed, Shahul P ^a   Ravishankar, Sudha ^a   Chatterji, Monalisa ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; CARBAMAZEPINE; COMPOUND A; LIGASE; PYRAZOLOPYRIMIDINE DERIVATIVE; RIFAMPICIN; UDP N ACETYLMURAMIC ACID LEVO ALANINE LIGASE; UNCLASSIFIED DRUG; ALANINE; CARRIER PROTEIN; ESCHERICHIA COLI PROTEIN; OUTER MEMBRANE PROTEIN; PEPTIDE SYNTHASE; TOLC PROTEIN, E COLI; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID;

ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CELL ACTIVITY; CELL DEATH; CELL MUTANT; CONTROLLED STUDY; ENZYME INHIBITION; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY; CYTOLOGY; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION;

ALANINE; BACTERIAL OUTER MEMBRANE PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE TRANSPORT PROTEINS; MUTATION; PEPTIDE SYNTHASES; PSEUDOMONAS AERUGINOSA; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID;

EID: 84907266463     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02890-14     Document Type: Article

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