Polyamines Inhibit Porin-Mediated Fluoroquinolone Uptake in Mycobacteria

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Sarathy, Jansy Passiflora ^a,d   Lee, Edmund ^b   Dartois, Véronique ^a,c,d  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADAVERINE; CIPROFLOXACIN; GATIFLOXACIN; LINEZOLID; MOXIFLOXACIN; OFLOXACIN; OUTER MEMBRANE PROTEIN; POLYAMINE; PORIN; PUTRESCINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RESERPINE; SPERMIDINE; SPERMINE; VERAPAMIL; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAM; CULTURE MEDIUM; QUINOLONE DERIVATIVE;

ARTICLE; DOWN REGULATION; DRUG ACCUMULATION; DRUG MECHANISM; DRUG SENSITIVITY; DRUG UPTAKE; ESCHERICHIA COLI; GENE EXPRESSION; MEMBRANE PERMEABILITY; MYCOBACTERIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OUTER MEMBRANE; PHENOTYPE; ACTIVE TRANSPORT; ANTAGONISTS AND INHIBITORS; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CULTURE MEDIUM; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PH; PHARMACOLOGY;

CORYNEBACTERINEAE; ESCHERICHIA COLI; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMS; BIOLOGICAL TRANSPORT, ACTIVE; CADAVERINE; CELL MEMBRANE PERMEABILITY; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROQUINOLONES; GENE EXPRESSION REGULATION, BACTERIAL; HYDROGEN-ION CONCENTRATION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; POLYAMINES; PORINS; PUTRESCINE; SPERMIDINE; SPERMINE;

EID: 84878623303     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065806     Document Type: Article

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