Identification of an inhibitor of the MurC enzyme, which catalyzes an essential step in the peptidoglycan precursor synthesis pathway

Assay and Drug Development Technologies

Volumn 6, Issue 1, 2008, Pages 95-103

  Zawadzke, Laura E ^a   Norcia, Michael ^a   Desbonnet, Charlene R ^a   Wang, Hong ^a   Freeman Cook, Kevin ^a   Dougherty, Thomas J ^a,b  

^a PFIZER INC   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL ENZYME; C 1; ENZYME INHIBITOR; MURC ENZYME; MURC ENZYME INHIBITOR; PEPTIDOGLYCAN; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ACINETOBACTER; ACINETOBACTER BAYLYI; ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; ENANTIOMER; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HIGH THROUGHPUT SCREENING; IC 50; KLEBSIELLA PNEUMONIAE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN SYNTHESIS; PROTEUS MIRABILIS; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; CARRIER PROTEINS; DNA PRIMERS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PEPTIDE SYNTHASES; PEPTIDOGLYCAN; PROTEUS MIRABILIS; RECEPTORS, PURINERGIC P2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749131703     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2007.114     Document Type: Article

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