Antioxidant vitamin supplementation reduces arterial stiffness in adults: A systematic review and meta-analysis of randomized controlled trials

Journal of Nutrition

Volumn 144, Issue 10, 2014, Pages 1594-1602

  Ashor, Ammar W ^a,b   Siervo, Mario ^a   Lara, Jose ^a   Oggioni, Clio ^a   Mathers, John C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b MUSTANSIRIYAH UNIVERSITY   (Iraq)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; RETINOL; VITAMIN;

ARTERIAL STIFFNESS; DIET SUPPLEMENTATION; DRUG EFFECTS; FACTUAL DATABASE; HUMAN; META ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANTIOXIDANTS; ASCORBIC ACID; BETA CAROTENE; DATABASES, FACTUAL; DIETARY SUPPLEMENTS; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VASCULAR STIFFNESS; VITAMIN A; VITAMIN E; VITAMINS;

EID: 84907252825     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.195826     Document Type: Article

References (57)

1. Shirwany NA, Zou MH. Arterial stiffness: a brief review. Acta Pharmacol Sin 2010;31:1267-76.
2. Cavalcante JL, Lima JA, Redheuil A, Al-Mallah MH. Aortic stiffness: current understanding and future directions. J Am Coll Cardiol 2011;57: 1511-22.
3. Sakuragi S, Abhayaratna WP. Arterial stiffness: methods of measurement, physiologic determinants and prediction of cardiovascular outcomes. Int J Cardiol 2010;138:112-8.
4. Laurent S, Boutouyrie P. Arterial stiffness: a new surrogate end point for cardiovascular disease? J Nephrol 2007;20(Suppl 12):S45-50.
5. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005;25:932-43.
6. Correia ML, Haynes WG. Arterial compliance and endothelial function. Curr Diab Rep 2007;7:269-75.
7. Patel RS, Al Mheid I, Morris AA, Ahmed Y, Kavtaradze N, Ali S, Dabhadkar K, Brigham K, Hooper WC, Alexander RW, et al. Oxidative stress is associated with impaired arterial elasticity. Atherosclerosis 2011;218:90-5.
8. Park S, Lakatta EG. Role of inflammation in the pathogenesis of arterial stiffness. Yonsei Med J 2012;53:258-61.
9. Estruch R, Ros E, Salas-Salvado J, Covas MI, Corella D, Aros F, Gomez-Gracia E, Ruiz-Gutierrez V, Fiol M, Lapetra J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279-90.
10. Shargorodsky M, Debby O, Matas Z, Zimlichman R. Effect of longterm treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutr Metab (Lond) 2010;7:55.
11. Zureik M, Galan P, Bertrais S, Mennen L, Czernichow S, Blacher J, Ducimetiere P, Hercberg S. Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries. Arterioscler Thromb Vasc Biol 2004;24:1485-91.
12. Higgins JPT, Green S (editors). Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated 2011 March]. The Cochrane Collaboration, 2011. Available from: www.cochrane-handbook.org.
13. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009;339:b2700.
14. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12.
15. Crowther M, Lim W, Crowther MA. Systematic review and metaanalysis methodology. Blood 2010;116:3140-6.
16. Cummings P. Arguments for and against standardized mean differences (effect sizes). Arch Pediatr Adolesc Med 2011;165:592-6.
17. Lewis S, Clarke M. Forest plots: trying to see the wood and the trees. BMJ 2001;322:1479-80.
18. Elbourne DR, Altman DG, Higgins JP, Curtin F, Worthington HV, Vail A. Meta-analyses involving cross-over trials: methodological issues. Int J Epidemiol 2002;31:140-9.
19. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
20. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
21. Nightingale AK, Blackman DJ, Field R, Glover NJ, Pegge N, Mumford C, Schmitt M, Ellis GR, Morris-Thurgood JA, Frenneaux MP. Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failure. Clin Sci (Lond) 2003;104:529-35.
22. Rasool AH, Rahman AR, Yuen KH, Wong AR. Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E. Arch Pharm Res 2008;31:1212-7.
23. Rasool AH, Yuen KH, Yusoff K, Wong AR, Rahman AR. Dose dependent elevation of plasma tocotrienol levels and its effect on arterial compliance, plasma total antioxidant status, and lipid profile in healthy humans supplemented with tocotrienol rich vitamin E. J Nutr Sci Vitaminol (Tokyo) 2006;52:473-8.
24. Arcaro G, Fava C, Dagradi R, Faccini G, Gaino S, Degan M, Lechi C, Lechi A, Minuz P. Acute hyperhomocysteinemia induces a reduction in arterial distensibility and compliance. J Hypertens 2004;22:775-81.
25. Kelly RP, Poo Yeo K, Isaac H, Lee CY, Huang SH, Teng L, Halliwell B, Wise S. Lack of effect of acute oral ingestion of vitamin C on oxidative stress, arterial stiffness or blood pressure in healthy subjects. Free Radic Res 2008;42:514-22.
26. Mullan BA, Ennis CN, Fee HJ, Young IS, McCance DR. Protective effects of ascorbic acid on arterial hemodynamics during acute hyperglycemia. Am J Physiol Heart Circ Physiol 2004;287:H1262-8.
27. Plantinga Y, Ghiadoni L, Magagna A, Giannarelli C, Franzoni F, Taddei S, Salvetti A. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens 2007;20:392-7.
28. Rasool AHG, Rehman A, Wan Yusuf WN, Rahman ARA. Vitamin E and its effect on arterial stiffness in postmenopausal women-a randomized controlled trial. Int J Clin Pharmacol Ther 2003;41:587-92.
29. Wilkinson IB, Megson IL, MacCallum T, Rooijmans DF, Johnson SM, Boyd JL, Cockcroft JR, Webb DJ. Acute methionine loading does not alter arterial stiffness in humans. J Cardiovasc Pharmacol 2001;37:1-5.
30. Darko D, Dornhorst A, Kelly FJ, Ritter JM, Chowienczyk PJ. Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes. Clin Sci (Lond) 2002;103:339-44.
31. Mullan BA, Young IS, Fee H, McCance DR. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension 2002;40:804-9.
32. Nightingale AK, Crilley JG, Pegge NC, Boehm EA, Mumford C, Taylor DJ, Styles P, Clarke K, Frenneaux MP. Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure. Eur J Heart Fail 2007;9:287-91.
33. Wilkinson IB, Megson IL, MacCallum H, Sogo N, Cockcroft JR, Webb DJ. Oral vitamin C reduces arterial stiffness and platelet aggregation in humans. J Cardiovasc Pharmacol 1999;34:690-3.
34. Magliano D, McNeil J, Branley P, Shiel L, Demos L, Wolfe R, Kotsopoulos D, McGrath B. The Melbourne Atherosclerosis Vitamin E Trial (MAVET): a study of high dose vitamin E in smokers. Eur J Cardiovasc Prev Rehabil 2006;13:341-7.
35. Mottram P, Shige H, Nestel P. Vitamin E improves arterial compliance in middle-aged men and women. Atherosclerosis 1999;145:399-404.
36. Skyrme-Jones RA, O'Brien RC, Berry KL, Meredith IT. Vitamin E supplementation improves endothelial function in type I diabetes mellitus: a randomized, placebo-controlled study. J Am Coll Cardiol 2000;36:94-102.
37. Studinger P, Mersich B, Lenard Z, Somogyi A, Kollai M. Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, healthy adults. Auton Neurosci 2004;113:63-70.
38. Schutte AE, Huisman HW, Oosthuizen W, Van Rooyen JM, Jerling JC. Cardiovascular effects of oral supplementation of vitamin C, E and folic acid in young healthy males. Int J Vitam Nutr Res 2004;74:285-93.
39. Nüesch E, Trelle S, Reichenbach S, Rutjes AW, Tschannen B, Altman DG, Egger M, Juni P. Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study. BMJ 2010;341:c3515.
40. Kals J, Kampus P, Kals M, Zilmer K, Kullisaar T, Teesalu R, Pulges A, Zilmer M. Impact of oxidative stress on arterial elasticity in patients with atherosclerosis. Am J Hypertens 2006;19:902-8.
41. Orbe J, Rodriguez JA, Arias R, Belzunce M, Nespereira B, Perez-Ilzarbe M, Roncal C, Paramo JA. Antioxidant vitamins increase the collagen content and reduce MMP-1 in a porcine model of atherosclerosis: implications for plaque stabilization. Atherosclerosis 2003;167:45-53.
42. McGrane MM. Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. J Nutr Biochem 2007;18:497-508.
43. Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P, Lunec J. Vitamin C exhibits pro-oxidant properties. Nature 1998;392:559.
44. Rietjens IM, Boersma MG, Haan L, Spenkelink B, Awad HM, Cnubben NH, van Zanden JJ, Woude H, Alink GM, Koeman JH. The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids. Environ Toxicol Pharmacol 2002;11:321-33.
45. LevineM, Daruwala RC, Park JB, Rumsey SC,Wang Y. Does vitamin C have a pro-oxidant effect? Nature 1998;395:231; author reply 232.
46. Poulsen HE, Weimann A, Salonen JT, Nyyssonen K, Loft S, Cadet J, Douki T, Ravanat JL. Does vitamin C have a pro-oxidant effect? Nature 1998;395:231-2.
47. Suh J, Zhu BZ, Frei B. Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxide. Free Radic Biol Med 2003;34:1306-14.
48. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 highrisk individuals: a randomised placebo-controlled trial. Lancet 2002;360: 7-22.
49. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians Health Study II randomized controlled trial. JAMA 2008;300:2123-33.
50. Myung SK, JuW, Cho B, Oh SW, Park SM, Koo BK, Park BJ. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ 2013;346:f10.
51. Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37-46.
52. Schürks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ 2010;341:c5702.
53. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briancon S. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004;164:2335-42.
54. Mark SD,WangW, Fraumeni JF Jr, Li JY, Taylor PR,Wang GQ, GuoW, Dawsey SM, Li B, Blot WJ. Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation: the Linxian Nutrition Intervention Trial. Am J Epidemiol 1996;143:658-64.
55. Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol 2014;63:636-46.
56. Vlachopoulos C, Aznaouridis K, O'Rourke MF, Safar ME, Baou K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J 2010;31:1865-71.
57. Kelley GA, Tran ZV. Original metric vs. standardized effect sizes for meta-analysis of clinical data. Prev Cardiol 2001;4:40-5