Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors

Nutrition and Metabolism

Volumn 7, Issue , 2010, Pages

  Shargorodsky, Marina ^a,b   Debby, Ortal ^a   Matas, Zipora ^a   Zimlichman, Reuven ^a,b  

^a WOLFSON MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE; ALPHA TOCOPHEROL; ANGIOTENSIN RECEPTOR ANTAGONIST; ASCORBIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C PEPTIDE; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENDOTHELIN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; RENIN; SELENIUM; TRIACYLGLYCEROL; UBIDECARENONE;

ADULT; AGED; ALDOSTERONE BLOOD LEVEL; ARTERY COMPLIANCE; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DYSLIPIDEMIA; FEMALE; GLUCOSE BLOOD LEVEL; HEMODYNAMICS; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMORAL IMMUNITY; HYPERTENSION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; PLASMA RENIN ACTIVITY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 77954189337     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-7-55     Document Type: Article

References (34)

1. Role of oxidative modifications in atherosclerosis. R Stocker JF Keaney Jr, Physiol Rev 2004 84 1381 1478 10.1152/physrev.00047.2003 15383655
2. Oxidative stress, AGE, and atherosclerosis. E Schleicher U Friess, Kidney International 2007 72 17 S26 10.1038/sj.ki.5002382 (Pubitemid 47172557)
3. Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. KK Griendling GA FitzGerald, Circulation 2003 108 1912 1916 10.1161/01.CIR.0000093660.86242.BB 14568884
4. Oxidative stress as a regulator of gene expression in the vasculature. C Kunsch RM Medford, Circ Res 1999 85 753 766 10521248
5. Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes. NR Madamanchi ZS Hakim MS Runge, J Thromb Haemost 2005 3 254 267 10.1111/j.1538-7836.2004.01085.x 15670030
6. Poor glycaemic control is associated with reduced serum free radical scavenging (antioxidant) activity in non-insulin-dependent diabetes mellitus. SR Maxwell H Thomason D Sandler C LeGuen MA Baxter GH Thorpe AF Jones AH Barnett, Ann Clin Biochem 1997 34 638 644 9367001
7. Increased superoxide anion production by platelets in hypercholesterolemic patients. V Sanguigni P Pignatelli D Caccese FM Pulcinelli L Lenti R Magnaterra F Martini R Lauro F Violi, Thromb Haemost 2002 87 796 801 12038779 (Pubitemid 34516604)
8. NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat. RA Beswick AM Dorrance R Leite RC Webb, Hypertension 2001 38 1107 11 10.1161/hy1101.093423 11711506
9. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. JD Morrow B Frei AW Longmire JM Gaziano SM Lynch Y Shyr WE Strauss JA Oates LJ Roberts, N Engl J Med 1995 332 1198 203 10.1056/NEJM199505043321804 7700313
10. Mechanisms, pathophysiology, and therapy of arterial stiffness. SJ Zieman V Melenovsky DA Kass, Arterioscler Thromb Vasc Biol 2005 25 932 943 10.1161/01.ATV.0000160548.78317.29 15731494
11. Arterial distensibility in humans. Modulating mechanisms, alterations in diseases and effects of treatment. C Giannattasio G Mancia, J Hypertens 2002 20 1889 1899 10.1097/00004872-200210000-00001 12359960
12. Non- invasive pulse wave analysis for the detection of arterial vascular disease. JN Cohn S Finkelstein G McVeigh D Morgan I LeMay J Robinson J Mock, Hypertension 1995 26 503 508 7649589
13. Determination of arterial compliance using blood pressure waveform analysis with the CR-2000 system: Reliability, repeatability, and establishment of normal values for healthy European population. R Zimlichman M Shargorodsky M Boaz D Duprez D Rahn D Rizzoni AC Payeras C Hamm G McVeigh, Am J Hypertens 2005 18 1 65 71 10.1016/j.amjhyper.2004.08.013 15691619
14. Vascular effects following homozygous disruption of p47(phox): An essential component of NADPH oxidase. E Hsich BH Segal PJ Pagano FE Rey B Paigen J Deleonardis RF Hoyt SM Holland T Finkel, Circulation 2000 101 1234 1236 10725280
15. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. X Chen RM Touyz J Bae Park EL Schiffrin, Hypertension 2001 38 606 611 10.1161/hy09t1.094005 11566940
16. Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. BJ Wu K Kathir PK Witting K Beck K Choy C Li KD Croft TA Mori D Tanous MR Adams AK Lau R Stocker, J Exp Med 2006 203 1117 1127 10.1084/jem.20052321 16606673
17. Antioxidant Supplementation in Atherosclerosis Prevention Study (ASAP): a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. JT Salonen K Nyyssönen R Salonen HM Lakka J Kaikkonen E Porkkala-Sarataho S Voutilainen TA Lakka T Rissanen L Leskinen TP Tuomainen VP Valkonen U Ristonmaa HE Poulsen, J Intern Med 2000 248 377 386 10.1046/j.1365-2796.2000.00752.x 11123502
18. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. GD Plotnick MC Corretti RA Vogel, JAMA 1997 278 1682 1686 10.1001/jama.278.20.1682 9388088
19. Low-density lipoprotein postsecretory modification, monocyte function, and circulating adhesion molecules in type 2 diabetic patients with and without macrovascular complications: the effect of -tocopherol supplementation. S Devaraj I Jialal, Circulation 2000 102 191 196 10889130
20. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). NG Stephens A Parsons PM Schofield F Kelly K Cheeseman MJ Mitchinson, Lancet 1996 347 781 786 10.1016/S0140-6736(96)90866-1 8622332
21. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. M Boaz S Smetana T Weinstein Z Matas U Gafter A Iaina A Knecht Y Weissgarten D Brunner M Fainaru MS Green, Lancet 2000 356 1213 1218 10.1016/S0140-6736(00)02783-5 11072938
22. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. BG Brown XQ Zhao A Chait LD Fisher MC Cheung JS Morse AA Dowdy EK Marino EL Bolson P Alaupovic J Frohlich JJ Albers, N Engl J Med 2001 345 1583 1592 10.1056/NEJMoa011090 11757504
23. Vitamin E supplementation and cardiovascular events in high-risk patients. Heart Outcomes Prevention Evaluation Study Investigators. S Yusuf G Dagenais J Pogue J Bosch P Sleight, N Engl J Med 2000 342 154 160 10.1056/NEJM200001203420302 10639540
24. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomized trial in general practice. Collaborative Group of the Primary Prevention Project, Lancet 2001 357 89 95 10.1016/S0140-6736(00)03539-X 11197445
25. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. ER Miller R Pastor-Barriuso D Dalal RA Riemersma LJ Appel E Guallar, Ann Intern Med 2005 142 37 46 15537682
26. The effect of vitamin C or vitamin E supplementation on basal and H2O2-induced DNA damage in human lymphocytes. LA Brennan GM Morris GR Wasson BM Hannigan YA Barnett, Br J Nutr 2000 84 195 202 10.1079/096582197388680 11029970
27. Nutritional supplementation with antioxidants decreases chromosomal damage in humans. M Dusinsk A Kazimírov M Barancokov M Beno B Smolkov A Horsk K Raslov L Wsálov AR Collins, Mutagenesis 2003 18 371 376 10.1093/mutage/geg002 12840111
28. 10improves endothelial dysfunction of the brachial artery in type II diabetes mellitus. GF Watts DA Playford KD Croft NC Ward TA Mori V Burke, Diabetologia 2002 45 420 426 10.1007/s00125-001-0760-y 11914748
29. Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase. S Miller SW Walker JR Arthur F Nicol K Pickard MH Lewin AF Howie GJ Beckett, Clin Sci (Lond) 2001 100 5 543 50 10.1042/CS20000299 11294695
30. 10improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. JM Hodgson GF Watts DA Playford V Burke KD Croft, European Journal of Clinical Nutrition 2002 56 1137 1142 10.1038/sj.ejcn.1601464 12428181
31. Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects. PJ Manning WH Sutherland RJ Walker SM Williams SA De Jong AR Ryalls EA Berry, Diabetes Care 2004 27 2166 2171 10.2337/diacare.27.9.2166 15333479
32. Vitamin E can reduce blood pressure in mild hypertensives. M Boshtam M Rafiei K Sadeghi N Sarraf-Zadegan, Int J Vitam Nutr Res 2002 72 309 314 10.1024/0300-9831.72.5.309 12463106
33. Treatment of hypertension with ascorbic acid. SJ Duffy N Gokce M Holbrook A Huang B Frei JF Keaney Jr JA Vita, Lancet 1999 354 2048 2049 10.1016/S0140-6736(99)04410-4 10636373
34. Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension. R Rodrigo H Prat W Passalacqua J Araya JP Bächler, Clin Sci (Lond) 2008 114 10 625 34 10.1042/CS20070343 17999638