Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins

Journal of Medicinal Chemistry

Volumn 57, Issue 17, 2014, Pages 7382-7395

  Chany, Anne Caroline ^a   Veyron Churlet, Romain ^b   Tresse, Cédric ^a   Mayau, Véronique ^b   Casarotto, Virginie ^a   Le Chevalier, Fabien ^b   Guenin Macé, Laure ^b   Demangel, Caroline ^b   Blanchard, Nicolas ^c  

^a Ecole Nationale Superieure de Chimie de Mulhouse   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

12,13,15 TRIS[(TERT BUTYLDIMETHYLSILYL)OXY] 4,6,10 TRIMETHYLHEXADECA 2,4,6,8,10 PENTANOIC ACID; 2,3,5 TRIS[( TERT BUTYLDIMETHYLSILYL)OXY]HEXANAL; 2,3,5 TRIS[(TERT BUTYLDIMETHYLSILYL)OXY]HEXAN 1 OL; 7 METHYL 2 OXO 12 (PROPAN 2 YL) 1 OXACYCLODODEC 9 EN 6 YL 12,13,15 TRIHYDROXY 4,6,10 TRIMETHYLHEXADECA 2,4,6,8,10 PENTANOATE; ETHYL 12,13,15 TRIS[(TERT BUTYLDIMETHYLSILYL)OXY] 4,6,10 TRIMETHYLHEXADECA 2,4,6,8,10 PENTANOATE; ETHYL 4,5,7 TRIS [(TERT BUTYLDIMETHYLSILYL)OXY] 2 METHYLOCT 2 ENOATE; ETHYL 5 [(TERT BUTYLDIMETHYLSILYL)OXY] 2,3 DIHYDROXYHEXANOATE; ETHYL 5 [(TERT BUTYLDIMETHYLSILYL)OXY]HEX 2 ENOATE; MACROLIDE; MYCOLACTONE DERIVATIVE; TRIS( TERT BUTYLDIMETHYLSILYLOXY) 1 IODO 3 METHYLNONA 1,3 DIENE; TRIS( TERT BUTYLDIMETHYLSILYLOXY) 1 TRIBUTYLSTANNYL 3 METHYLNONA 1,3 DIENE; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN; BACTERIAL TOXIN; MYCOLACTONE; PROTEIN BINDING;

ARTICLE; CELL ADHESION; CELL ADHESION ASSAY; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; STILLE REACTION; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HELA CELL LINE; KINETICS; METABOLISM; MYCOBACTERIUM ULCERANS;

BACTERIAL TOXINS; CELL ADHESION; HELA CELLS; HUMANS; KINETICS; MACROLIDES; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MYCOBACTERIUM ULCERANS; PROTEIN BINDING; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 84907212348     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5008819     Document Type: Article

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