Dioscin inhibits adipogenesis through the AMPK/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice

International Journal of Molecular Medicine

Volumn 34, Issue 5, 2014, Pages 1401-1408

  Poudel, Barun ^a   Lim, Seong Won ^a   Ki, Hyeon Hui ^a   Nepali, Sarmila ^a   Lee, Young Mi ^b   Kim, Dae Ki ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Wonkwang University   (South Korea)

Author keywords

3T3 L1; Adipogenesis; AMP activated protein kinase; Dioscin; High fat diet; Mitogen activated protein kinases; Obesity

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ANTILIPEMIC AGENT; ANTIOBESITY AGENT; DIOSCIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SAPONIN DERIVATIVE; STEROID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; DIOSGENIN; TRIACYLGLYCEROL;

3T3 CELL LINE; ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EXPOSURE; DRUG MECHANISM; ENZYME PHOSPHORYLATION; EXPERIMENTAL OBESITY; FLOW CYTOMETRY; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; LIPID STORAGE; MALE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; WEIGHT REDUCTION; WESTERN BLOTTING; ADIPOSE TISSUE; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; BODY COMPOSITION; C57BL MOUSE; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; WEIGHT GAIN;

3T3-L1 CELLS; ACETYL-COA CARBOXYLASE; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BODY COMPOSITION; CELL DIFFERENTIATION; CELL SURVIVAL; DIET, HIGH-FAT; DIOSGENIN; DOWN-REGULATION; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRIGLYCERIDES; WEIGHT GAIN;

EID: 84907210183     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1921     Document Type: Article

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