Salvianolic acid A reverses paclitaxel resistance in human breast cancer MCF-7 cells via targeting the expression of transgelin 2 and attenuating PI3 K/Akt pathway

Phytomedicine

Volumn 21, Issue 12, 2014, Pages 1725-1732

  Cai, Jiangxia ^a,b   Chen, Siying ^a   Zhang, Weipeng ^a   Zheng, Xiaowei ^a   Hu, Sasa ^a   Pang, Chengsen ^a   Lu, Jun ^a   Xing, Jianfeng ^a   Dong, Yalin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Department of Pharmacy   (China)

Author keywords

Breast cancer; Paclitaxel resistance; Reversal mechanism; Salvianolic acid A; Transgelin 2

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; PHENOL DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SALVIANOLIC ACID A; TRANSGELIN; TRANSGELIN 2; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; CAFFEIC ACID DERIVATIVE; LACTIC ACID DERIVATIVE; MUSCLE PROTEIN; TRANSGELIN 2 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BREAST CANCER; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CHEMICAL STRUCTURE; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; GENE SILENCING; MCF 7 CELL LINE; METABOLISM;

CAFFEIC ACIDS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; LACTATES; MCF-7 CELLS; MICROFILAMENT PROTEINS; MOLECULAR STRUCTURE; MUSCLE PROTEINS; PACLITAXEL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84907204851     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.08.007     Document Type: Article

References (29)

1. H. Atmaca, E. Bozkurt, S. Uzunoglu, R. Uslu, and B. Karaca A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells Toxicol. Lett. 221 2013 128 136
2. J. Cai, S. Chen, W. Zhang, Y. Wei, J. Lu, J. Xing, and Y. Dong Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2 Phytomedicine 21 2014 984 991
3. S. Chen, Q. Dong, S. Hu, J. Cai, W. Zhang, J. Sun, T. Wang, J. Xie, H. He, J. Xing, J. Lu, and Y. Dong Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells Mol. Biosyst. 10 2014 294 303
4. Z. Cheng, N. Yang, W. Liang, X. Yan, L. Li, and L. Pan Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells Leuk. Lymphoma 53 2012 1383 1389
5. A.S. Clark, K. West, S. Streicher, and P.A. Dennis Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells Mol. Cancer Ther. 1 2002 707 717
6. H.C. Cooray, T. Janvilisri, H.W. van Veen, S.B. Hladky, and M.A. Barrand Interaction of the breast cancer resistance protein with plant polyphenols Biochem. Biophys. Res. Commun. 317 2004 269 275
7. H.Y. Fan, F.H. Fu, M.Y. Yang, H. Xu, A.H. Zhang, and K. Liu Antiplatelet and antithrombotic activities of salvianolic acid A Thromb. Res. 126 2010 e17 e22
8. F. Gueritte General and recent aspects of the chemistry and structure-activity relationships of taxoids Curr. Pharm. Des. 7 2001 1229 1249
9. B.T. Hennessy, D.L. Smith, P.T. Ram, Y. Lu, and G.B. Mills Exploiting the PI3K/AKT pathway for cancer drug discovery Nat. Rev. Drug Discov. 4 2005 988 1004
10. Z.S. Huang, C.L. Zeng, L.J. Zhu, L. Jiang, N. Li, and H. Hu Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of phosphoinositide 3-kinase J. Thromb. Haemost. 8 2010 1383 1393
11. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA: Cancer J. Clin. 61 2011 69 90
12. J. Jodoin, M. Demeule, and R. Beliveau Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols Biochim. Biophys. Acta 1542 2002 149 159
13. T.R. Kim, E.W. Cho, S.G. Paik, and I.G. Kim Hypoxia-induced SM22alpha in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy FEBS Lett. 586 2012 303 309
14. C.S. Klade, T. Voss, E. Krystek, H. Ahorn, K. Zatloukal, K. Pummer, and G.R. Adolf Identification of tumor antigens in renal cell carcinoma by serological proteome analysis Proteomics 1 2001 890 898
15. C. Knuefermann, Y. Lu, B. Liu, W. Jin, K. Liang, L. Wu, M. Schmidt, G.B. Mills, J. Mendelsohn, and Z. Fan HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells Oncogene 22 2003 3205 3212
16. Y.L. Lin, T.F. Lee, Y.J. Huang, and Y.T. Huang Antiproliferative effect of salvianolic acid A on rat hepatic stellate cells J. Pharm. Pharmacol. 58 2006 933 939
17. B.T. McGrogan, B. Gilmartin, D.N. Carney, and A. McCann Taxanes, microtubules and chemoresistant breast cancer Biochim. Biophys. Acta 1785 2008 96 132
18. K. Miller, M. Wang, J. Gralow, M. Dickler, M. Cobleigh, E.A. Perez, T. Shenkier, D. Cella, and N.E. Davidson Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer N. Engl. J. Med. 357 2007 2666 2676
19. Y. Ou, L. Ma, Z. Huang, W. Zhou, C. Zhao, B. Zhang, Y. Song, C. Yu, and Q. Zhan Overexpression of cyclin B1 antagonizes chemotherapeutic-induced apoptosis through PTEN/Akt pathway in human esophageal squamous cell carcinoma cells Cancer Biol. Ther. 14 2013 45 55
20. J.H. Rho, M.H. Roehrl, and J.Y. Wang Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma J. Proteome Res. 8 2009 5610 5618
21. E. Seront, A. Pinto, C. Bouzin, L. Bertrand, J.P. Machiels, and O. Feron PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activation Br. J. Cancer 109 2013 1586 1592
22. C. Shapland, P. Lowings, and D. Lawson Identification of new actin-associated polypeptides that are modified by viral transformation and changes in cell shape J. Cell Biol. 107 1988 153 161
23. I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat. Rev. Cancer 2 2002 489 501
24. M.D. White, L. Chan, J.W. Antoon, and B.S. Beckman Targeting ovarian cancer and chemoresistance through selective inhibition of sphingosine kinase-2 with ABC294640 Anticancer Res. 33 2013 3573 3579
25. C.P. Wu, A.M. Calcagno, S.B. Hladky, S.V. Ambudkar, and M.A. Barrand Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5) FEBS J. 272 2005 4725 4740
26. Z.M. Wu, T. Wen, Y.F. Tan, Y. Liu, F. Ren, and H. Wu Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats Basic Clin. Pharmacol. Toxicol. 100 2007 115 120
27. H. Yoshino, T. Chiyomaru, H. Enokida, K. Kawakami, S. Tatarano, K. Nishiyama, N. Nohata, N. Seki, and M. Nakagawa The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer Br. J. Cancer 104 2011 808 818
28. S.H. Zhang, J. Su, and Y.S. Zhen Salvianolic acid A inhibits nucleoside transport and potentiates the antitumor activity of chemotherapeutic drugs Acta Pharm. Sin. 39 2004 496 499
29. Y. Zhang, Y. Ye, D. Shen, K. Jiang, H. Zhang, W. Sun, J. Zhang, F. Xu, Z. Cui, and S. Wang Identification of transgelin-2 as a biomarker of colorectal cancer by laser capture microdissection and quantitative proteome analysis Cancer Sci. 101 2010 523 529