Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of phosphoinositide 3-kinase

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 6, 2010, Pages 1383-1393

  Huang, Z S ^a   Zeng, C L ^b   Zhu, L J ^a   Jiang, L ^a   Li, N ^a,c   Hu, H ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b LISHUI CENTRAL HOSPITAL   (China)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Arterial thrombosis; PI3K; Platelets; Protein kinase B Akt; Salvianolic acid A

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 MORPHOLINO 8 PHENYLCHROMONE; 9 (1 ANILINOETHYL) 7 METHYL 2 MORPHOLINOPYRIDO[1,2 A]PYRIMIDIN 4 ONE; ADENOSINE DIPHOSPHATE; COLLAGEN; FIBRINOGEN; PADGEM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; SALVIA MILTIORRHIZA EXTRACT; SALVIANOLIC ACID A; THROMBIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; DRUG INHIBITION; DRUG POTENTIATION; FEMALE; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE AGGREGATION; MALE; MESENTERIC ARTERY OCCLUSION; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ADULT; ANIMALS; ARTERIES; CAFFEIC ACIDS; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; HUMANS; LACTATES; MALE; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PLATELET ACTIVATION; PLATELET AGGREGATION; SIGNAL TRANSDUCTION; THROMBIN; THROMBOSIS; THROMBOXANES;

EID: 77954477091     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2010.03859.x     Document Type: Article

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