Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2

Phytomedicine

Volumn 21, Issue 7, 2014, Pages 984-991

  Cai, Jiangxia ^a   Chen, Siying ^a   Zhang, Weipeng ^a   Hu, Sasa ^a   Lu, Jun ^a   Xing, Jianfeng ^a   Dong, Yalin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Breast cancer; Paclitaxel resistance; Paeonol; Reverse; Transgelin 2

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; PEONOL; TRANSGELIN; TRANSGELIN 2; UNCLASSIFIED DRUG; VERAPAMIL; ABC TRANSPORTER; ABCB1 PROTEIN, HUMAN; ABCG2 PROTEIN, HUMAN; ACETOPHENONE DERIVATIVE; ACTIN BINDING PROTEIN; ANTINEOPLASTIC AGENT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; MUSCLE PROTEIN; TRANSGELIN 2 PROTEIN, HUMAN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER RESISTANCE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; UPREGULATION; BREAST NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; MCF 7 CELL LINE; METABOLISM; PATHOLOGY;

PAEONIA SUFFRUTICOSA;

ACETOPHENONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MCF-7 CELLS; MICROFILAMENT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUSCLE PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEINS; PACLITAXEL; PROMOTER REGIONS, GENETIC; UP-REGULATION;

EID: 84901585297     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.02.012     Document Type: Article

References (26)

1. M.H. Bao, Y.W. Zhang, and H.H. Zhou Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-kappaB pathway Journal of Ethnopharmacology 146 2013 543 551
2. L. Fan, B. Song, G. Sun, T. Ma, F. Zhong, and W. Wei Endoplasmic reticulum stress-induced resistance to Doxorubicin is reversed by paeonol treatment in human hepatocellular carcinoma cells Plos One 8 2013 e62627
3. P.K. Fu, C.L. Wu, T.H. Tsai, and C.L. Hsieh Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats Evidence-Based Complementary and Alternative Medicine 2012 2012 837513
4. S.W. Himaya, B. Ryu, Z.J. Qian, and S.K. Kim Paeonol from Hippocampus kuda Bleeler suppressed the neuro-inflammatory responses in vitro via NF-kappaB and MAPK signaling pathways Toxicology In Vitro 26 2012 878 887
5. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA: A Cancer Journal for Clinicians 61 2011 69 90
6. K. Kawakami, H. Enokida, T. Chiyomaru, S. Tatarano, H. Yoshino, I. Kagara, T. Gotanda, T. Tachiwada, K. Nishiyama, N. Nohata, N. Seki, and M. Nakagawa The functional significance of miR-1 and miR-133a in renal cell carcinoma European Journal of Cancer 48 2012 827 836
7. H. Kim, G.S. Park, J.E. Lee, and J.H. Kim A leukotriene B4 receptor-2 is associated with paclitaxel resistance in MCF-7/DOX breast cancer cells British Journal of Cancer 109 2013 351 359
8. S.A. Kim, H.J. Lee, K.S. Ahn, E.O. Lee, S.H. Choi, S.J. Jung, J.Y. Kim, N. Baek, and S.H. Kim Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases Biological & Pharmaceutical Bulletin 32 2009 1142 1147
9. T.R. Kim, E.W. Cho, S.G. Paik, and I.G. Kim Hypoxia-induced SM22alpha in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy FEBS Letters 586 2012 303 309
10. S. Li, Y. Lei, Y. Jia, N. Li, M. Wink, and Y. Ma Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells Phytomedicine 19 2011 83 87
11. J. Liu, Z. Jiang, J. Xiao, Y. Zhang, S. Lin, W. Duan, J. Yao, C. Liu, X. Huang, T. Wang, Z. Liang, R. Wang, S. Zhang, and L. Zhang Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines Phytomedicine 16 2009 1006 1013
12. B.T. McGrogan, B. Gilmartin, D.N. Carney, and A. McCann Taxanes, microtubules and chemoresistant breast cancer Biochimica et Biophysica Acta 1785 2008 96 132
13. K. Miller, M. Wang, J. Gralow, M. Dickler, M. Cobleigh, E.A. Perez, T. Shenkier, D. Cella, and N.E. Davidson Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer New England Journal of Medicine 357 2007 2666 2676
14. S. Murray, E. Briasoulis, H. Linardou, D. Bafaloukos, and C. Papadimitriou Taxane resistance in breast cancer: mechanisms, predictive biomarkers and circumvention strategies Cancer Treatment Reviews 38 2012 890 903
15. L.-H. Peng, S. Liu, S.-Y. Xu, L. Chen, Y.-H. Shan, W. Wei, W.-Q. Liang, and J.-Q. Gao Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin Phytomedicine 20 2013 1082 1087
16. R.K. Prinjha, C.E. Shapland, J.J. Hsuan, N.F. Totty, I.J. Mason, and D. Lawson Cloning and sequencing of cDNAs encoding the actin cross-linking protein transgelin defines a new family of actin-associated proteins Cell Motility and the Cytoskeleton 28 1994 243 255
17. X. Qi, Z. Chang, J. Song, G. Gao, and Z. Shen Adenovirus-mediated p53 gene therapy reverses resistance of breast cancer cells to adriamycin Anti-Cancer Drugs 22 2011 556 562
18. J.H. Rho, M.H. Roehrl, and J.Y. Wang Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma Journal of Proteome Research 8 2009 5610 5618
19. K. Snow, and W. Judd Characterisation of adriamycin- and amsacrine-resistant human leukaemic T cell lines British Journal of Cancer 63 1991 17 28
20. X.A. Wan, G.P. Sun, H. Wang, S.P. Xu, Z.G. Wang, and S.H. Liu Synergistic effect of paeonol and cisplatin on oesophageal cancer cell lines Digestive and Liver Disease 40 2008 531 539
21. H. Wang, Z. Zhai, N. Li, H. Jin, J. Chen, S. Yuan, L. Wang, J. Zhang, Y. Li, J. Yun, J. Fan, J. Yi, and R. Ling Steroidal saponin of Trillium tschonoskii. Reverses multidrug resistance of hepatocellular carcinoma Phytomedicine 20 2013 985 991
22. Y. Wang, X. Wang, H. Zhao, B. Liang, and Q. Du Clusterin confers resistance to TNF-alpha-induced apoptosis in breast cancer cells through NF-kappaB activation and Bcl-2 overexpression Journal of Chemotherapy 24 2012 348 357
23. S.G. Xu, P.J. Yan, and Z.M. Shao Differential proteomic analysis of a highly metastatic variant of human breast cancer cells using two-dimensional differential gel electrophoresis Journal of Cancer Research and Clinical Oncology 136 2010 1545 1556
24. S.P. Xu, G.P. Sun, Y.X. Shen, W.R. Peng, H. Wang, and W. Wei Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines Acta Pharmacologica Sinica 28 2007 869 878
25. Y. Zhang, Y. Ye, D. Shen, K. Jiang, H. Zhang, W. Sun, J. Zhang, F. Xu, Z. Cui, and S. Wang Identification of transgelin-2 as a biomarker of colorectal cancer by laser capture microdissection and quantitative proteome analysis Cancer Science 101 2010 523 529
26. L. Zhou, R. Zhang, L. Zhang, Y. Sun, W. Yao, A. Zhao, J. Li, and Y. Yuan Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer Cancer Science 104 2013 423 430