Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 Mice

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Snyder, Jessica M ^a   Treuting, Piper M ^a   Nagy, Lee ^a,b   Yam, Cathy ^a   Yi, Jaehun ^a   Brasfield, Alicia ^a   Nguyen, Lisa Phuong Anh ^a   Hajjar, Adeline M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; CYTOKINE; GALECTIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HISTIOCYTOSIS; HISTOPATHOLOGY; HUMAN; MALE; MOUSE; MYD88 GENE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROLIFERATIVE MULTISYSTEMIC HISTIOCYTOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; C57BL MOUSE; CROSS BREEDING; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION; GENE LOCUS; GENETICS; GENOTYPE; INTRACELLULAR SPACE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; SEVERITY OF ILLNESS INDEX; TRANSGENIC MOUSE;

MUS;

ANIMALS; CROSSES, GENETIC; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GALECTIN 3; GENE EXPRESSION; GENETIC LOCI; GENOTYPE; HISTIOCYTOSIS; HUMANS; INTRACELLULAR SPACE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYELOID DIFFERENTIATION FACTOR 88; PHENOTYPE; SEVERITY OF ILLNESS INDEX; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 84907196932     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107257     Document Type: Article

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