Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 24, 2013, Pages

  Upadhyay, Sanjeev Kumar ^a   Eckel Mahan, Kristin L ^a   Mirbolooki, M Reza ^a   Tjong, Indra ^a   Griffey, Stephen M ^b   Schmunk, Galina ^a   Koehne, Amanda ^b   Halbout, Briac ^a   Iadonato, Shawn ^c   Pedersen, Brian ^a   Borrelli, Emiliana ^a   Wang, Ping H ^a   Mukherjee, Jogeshwar ^a   Sassone Corsi, Paolo ^a   Chandy, K George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Kineta Inc   (United States)

Author keywords

Brown fat; Diabetes mellitus; Inflammation; Metabolic syndrome; Potassium channel

Indexed keywords

ANTIOBESITY AGENT; CHOLESTEROL; FAT; FATTY ACID; FRUCTOSE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LEPTIN; POTASSIUM CHANNEL KV1.3; SHK 186; SUGAR; THYROID HORMONE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DYSLIPIDEMIA; ENERGY EXPENDITURE; ENERGY METABOLISM; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FATTY LIVER; GENE DELETION; GLUCOSE TRANSPORT; GLYCOLYSIS; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LOCOMOTION; MALE; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT GAIN;

BROWN FAT; DIABETES MELLITUS; INFLAMMATION; METABOLIC SYNDROME; POTASSIUM CHANNEL;

ADIPOSE TISSUE, BROWN; ADIPOSITY; ANIMALS; BLOOD GLUCOSE; DIET; ENERGY INTAKE; ENERGY METABOLISM; FATTY LIVER; INSULIN RESISTANCE; KV1.3 POTASSIUM CHANNEL; LEPTIN; LIPIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; OBESITY; OXYGEN CONSUMPTION; PROTEINS; WEIGHT GAIN;

MUS;

EID: 84878978712     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221206110     Document Type: Article

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