Impact of hepcidin antimicrobial peptide on iron overload in tuberculosis patients

Scandinavian Journal of Infectious Diseases

Volumn 46, Issue 10, 2014, Pages 693-696

  Javaheri Kermani, Mina ^a   Farazmandfar, Touraj ^a,b   Ajami, Abolghasem ^b   Yazdani, Yaghoub ^a  

^a GOLESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Hepcidin; Iron; Polymorphism; Tuberculosis

Indexed keywords

FERRITIN; HEPCIDIN; IRON; HAMP PROTEIN, HUMAN;

ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IRON BLOOD LEVEL; IRON METABOLISM; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; TUBERCULOSIS; ADULT; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOLOGY; PATHOLOGY; POINT MUTATION;

ADULT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FERRITINS; GENOTYPE; HEPCIDINS; HUMANS; IRON; POINT MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; TUBERCULOSIS;

EID: 84907149564     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2014.929736     Document Type: Article

References (24)

1. Eurosurveillance editorial team. WHO publishes Global tuberculosis report 2013. Euro Surveill 2013; 18:20615.
2. Pieters J. Mycobacterium tuberculosis and the macrophage:maintaining a balance. Cell Host Microbe 2008; 3:399-407.
3. Rodriguez GM. Control of iron metabolism in Mycobacte-rium tuberculosis. Trends Microbiol 2006; 14:320-7.
4. Sow FB, Florence WC, Satoskar AR, Schlesinger LS, Zwilling BS, Lafuse WP. Expression and localization of hepcidin in macrophages:a role in host defense against tuberculosis. J Leukoc Biol 2007; 82:934-45.
5. Beisswenger C, Bals R. Functions of antimicrobial peptides in host defense and immunity. Curr Protein Pept Sci 2005; 6:255-64.
6. Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, et al. Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Hepatol Res 2005; 33:198-205.
7. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta 2012; 1823:1434-43.
8. Ganz T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol 2005; 18:171-82.
9. Leong W-I, Lonnerdal B. Hepcidin, the recently identifi ed peptide that appears to regulate iron absorption. J Nutr 2004; 134:1-4.
10. Roy CN, Andrews NC. Anemia of infl ammation:the hepcidin link. Curr Opin Hematol 2005; 12:107-11.
11. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron effl ux by binding to ferroportin and inducing its internalization. Science 2004; 306:2090-3.
12. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al. Positional cloning of zebrafi sh ferroportin1 identifi es a conserved vertebrate iron exporter. Nature 2000; 403:776-81.
13. Olakanmi O, Kesavalu B, Abdalla MY, Britigan BE. Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells. Microb Pathog 2013; 65:21-8.
14. Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol 2009; 122:78-86.
15. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and infl ammation. J Clin Invest 2002; 110:1037-44.
16. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, et al. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 2007; 117:1926-32.
17. Andreani M, Radio FC, Testi M, De Bernardo C, Troiano M, Majore S, et al. Association of hepcidin promoter c-582 A G variant and iron overload in thalassemia major. Haematologica 2009; 94:1293-6.
18. Parajes S, Gonzalez-Quintela A, Campos J, Quinteiro C, Dominguez F, Loidi L. Genetic study of the hepcidin gene (HAMP) promoter and functional analysis of the c-582A G variant. BMC Genet 2010; 11:110.
19. Bruno F, Bonalumi S, Camaschella C, Ferrari M, Cremonesi L. The-582A G variant of the HAMP promoter is not associated with high serum ferritin levels in normal subjects. Haematologica 2010; 95:849-50.
20. Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276:7806-10.
21. Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev Med 2011; 62:347-60.
22. Sow FB, Alvarez GR, Gross RP, Satoskar AR, Schlesinger LS, Zwilling BS, et al. Role of STAT1, NF-kappaB, and C/EBPbeta in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-gamma. J Leukoc Biol 2009; 86:1247-58.
23. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci 2001; 98:8780-5.
24. Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003; 33:21-2.