Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice

Diabetes

Volumn 62, Issue 11, 2013, Pages 3736-3746

  Mao, Jiaming ^a   Hu, Xiaomin ^a   Xiao, Yao ^a   Yang, Chao ^a   Ding, Yi ^a   Hou, Ning ^a   Wang, Jue ^a   Cheng, Heping ^a,b   Zhang, Xiuqin ^a  

^a PEKING UNIVERSITY   (China)

^b Peking University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC RESTRICTION; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE ABSORPTION; HOMEOSTASIS; HYPERPHAGIA; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE FUNCTION; INTESTINE VILLUS; LIPID DIET; MALE; MOUSE; MOUSE MODEL; NONHUMAN; OBESITY; OVERNUTRITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; UPREGULATION; ANIMAL; C57BL MOUSE; EMBRYOLOGY; INTESTINE MUCOSA; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; SMALL INTESTINE; PRENATAL DEVELOPMENT;

ANIMALS; BETA CATENIN; CALORIC RESTRICTION; CELL PROLIFERATION; DIET, HIGH-FAT; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; OVERNUTRITION; SIGNAL TRANSDUCTION;

EID: 84891676227     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0035     Document Type: Article

References (50)

1. Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 2008;28:629-636
2. Barsh GS, Schwartz MW. Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet 2002;3:589-600
3. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 2001;104:531-543
4. Redman LM, Ravussin E. Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes. Antioxid Redox Signal 2011;14:275-287
5. Capel F, Klimcáková E, Viguerie N, et al. Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes 2009;58:1558- 1567
6. Anderson RM, Shanmuganayagam D, Weindruch R. Caloric restriction and aging: studies in mice and monkeys. Toxicol Pathol 2009;37:47-51
7. Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature 2006;444:854-859
8. Karra E, Batterham RL. The role of gut hormones in the regulation of body weight and energy homeostasis. Mol Cell Endocrinol 2010;316:120-128
9. Trayhurn P, Bing C. Appetite and energy balance signals from adipocytes. Philos Trans R Soc Lond B Biol Sci 2006;361:1237-1249
10. Keelan M, Cheeseman CI, Clandinin MT, Thomson AB. Intestinal morphology and transport after ileal resection in rat is modified by dietary fatty acids. Clin Invest Med 1996;19:63-70
11. Petit V, Arnould L, Martin P, et al. Chronic high-fat diet affects intestinal fat absorption and postprandial triglyceride levels in the mouse. J Lipid Res 2007;48:278-287
12. Scoaris CR, Rizo GV, Roldi LP, et al. Effects of cafeteria diet on the jejunum in sedentary and physically trained rats. Nutrition 2010;26:312-320
13. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006;127:469-480
14. MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009;17:9-26
15. Crosnier C, Stamataki D, Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet 2006;7:349- 359
16. van der Flier LG, Clevers H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 2009;71:241-260
17. Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J 1998;17:1371-1384
18. Karrasch T, Spaeth T, Allard B, Jobin C. PI3K-dependent GSK3ß(Ser9)- phosphorylation is implicated in the intestinal epithelial cell wound-healing response. PLoS ONE 2011;6:e26340
19. Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res 2012;72:2822- 2832
20. Geske MJ, Zhang X, Patel KK, Ornitz DM, Stappenbeck TS. Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development 2008;135:2959-2968
21. Gouyon F, Caillaud L, Carriere V, et al. Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice. J Physiol 2003;552:823-832
22. Tanaka S, Terada K, Nohno T. Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells. J Mol Signal 2011;6:12
23. Ring DB, Johnson KW, Henriksen EJ, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 2003;52:588-595
24. Hardy S, St-Onge GG, Joly E, Langelier Y, Prentki M. Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. J Biol Chem 2005;280:13285-13291
25. Sun J, Jin T. Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. Cell Signal 2008;20:219-229
26. Vieira VJ, Valentine RJ, Wilund KR, Antao N, Baynard T, Woods JA. Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. Am J Physiol Endocrinol Metab 2009;296: E1164-E1171
27. Kellett GL, Brot-Laroche E. Apical GLUT2: a major pathway of intestinal sugar absorption. Diabetes 2005;54:3056-3062
28. van de Wetering M, Sancho E, Verweij C, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-250
29. Yamamoto M, Acevedo-Duncan M, Chalfant CE, Patel NA, Watson JE, Cooper DR. Acute glucose-induced downregulation of PKC-betaII accelerates cultured VSMC proliferation. Am J Physiol Cell Physiol 2000;279: C587-C595
30. Li YM, Schilling T, Benisch P, et al. Effects of high glucose on mesenchymal stem cell proliferation and differentiation. Biochem Biophys Res Commun 2007;363:209-215
31. Wang B, Bobe G, LaPres JJ, Bourquin LD. High sucrose diets promote intestinal epithelial cell proliferation and tumorigenesis in APC(Min) mice by increasing insulin and IGF-I levels. Nutr Cancer 2009;61:81-93
32. Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer 2011;11:886-895
33. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006;444:840-846
34. Powell AG, Apovian CM, Aronne LJ. New drug targets for the treatment of obesity. Clin Pharmacol Ther 2011;90:40-51
35. Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet 2010;375:2267-2277
36. Henriksen EJ. Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes. Curr Diabetes Rev 2010;6:285-293
37. Takaishi S, Shibata W, Tomita H, et al. In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice. Am J Physiol Gastrointest Liver Physiol 2011;300:G334-G344
38. Hansen EN, Tamboli RA, Isbell JM, et al. Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery. Am J Physiol Gastrointest Liver Physiol 2011;300:G795-G802
39. Gautier JF, Choukem SP, Girard J. Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes Metab 2008;34(Suppl. 2): S65-S72
40. de Wit NJ, Boekschoten MV, Bachmair EM, et al. Dose-dependent effects of dietary fat on development of obesity in relation to intestinal differential gene expression in C57BL/6J mice. PLoS ONE 2011;6:e19145
41. Al-Dwairi A, Pabona JM, Simmen RC, Simmen FA. Cytosolic malic enzyme 1 (me1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PLoS One 2012;7:e46716
42. de Wit NJ, Bosch-Vermeulen H, de Groot PJ, et al. The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BMC Med Genomics 2008;1:14
43. Chen Y, Hu Y, Zhou T, et al. Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. Am J Pathol 2009;175:2676-2685
44. Anagnostou SH, Shepherd PR. Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines. Biochem J 2008; 416:211-218
45. Rosner G, Rozen P, Bercovich D, et al. A protocol for genetic evaluation of patients with multiple colorectal adenomas and without evidence of APC gene mutation. Isr Med Assoc J 2010;12:549-553
46. Rowland KJ, Trivedi S, Lee D, Wan K, Kulkarni RN, Holzenberger M, Brubaker PL. Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion. Gastroenterology 2011;141:2166-2175
47. Dubé PE, Rowland KJ, Brubaker PL. Glucagon-like peptide-2 activates beta-catenin signaling in the mouse intestinal crypt: role of insulin-like growth factor-I. Endocrinology 2008;149:291-301
48. Sinclair EM, Drucker DJ. Proglucagon-derived peptides: mechanisms of action and therapeutic potential. Physiology (Bethesda) 2005;20: 357-365
49. Baldassano S, Amato A, Cappello F, Rappa F, Mulè F. Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet. J Endocrinol 2013;217:11-20
50. Dubé PE, Forse CL, Bahrami J, Brubaker PL. The essential role of insulinlike growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice. Gastroenterology 2006;131:589-605