Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Gingras, Jacinthe ^a   Smith, Sarah ^a   Matson, David J ^a   Johnson, Danielle ^a   Nye, Kim ^a   Couture, Lauren ^a   Feric, Elma ^a   Yin, Ruoyuan ^a   Moyer, Bryan D ^a   Peterson, Matthew L ^a   Rottman, James B ^a   Beiler, Rudolph J ^a   Malmberg, Annika B ^a   McDonough, Stefan I ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHANNEL NAV1.7; SCN9A PROTEIN, MOUSE;

ADULT; ADULTHOOD; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOSMIA; ARTICLE; CONGENITAL ANALGESIA; CONTROLLED STUDY; DORSAL ROOT; FEMALE; GANGLION; GENOTYPE; HYPERALGESIA; KNOCKOUT MOUSE; LATENT PERIOD; LOCOMOTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; SENSORY NERVE CELL; SKIN NERVE; SODIUM CURRENT; SURVIVAL RATE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; GENETICS; HUMAN; NERVOUS SYSTEM; NONMYELINATED NERVE; PAIN INSENSITIVITY, CONGENITAL; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SMELLING DISORDER;

MUS;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NERVE FIBERS, UNMYELINATED; NERVOUS SYSTEM; OLFACTION DISORDERS; PAIN INSENSITIVITY, CONGENITAL; PAIN THRESHOLD; PHENOTYPE; SENSORY RECEPTOR CELLS;

EID: 84907060519     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105895     Document Type: Article

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