Paroxysmal itch caused by gain-of-function Nav1.7 mutation

Pain

Volumn 155, Issue 9, 2014, Pages 1702-1707

  Devigili, Grazia ^a   Eleopra, Roberto ^a   Pierro, Tiziana ^b   Lombardi, Raffaella ^b   Rinaldo, Sara ^a   Lettieri, Christian ^a   Faber, Catharina G ^c   Merkies, Ingemar S J ^c,d   Waxman, Stephen G ^e,f   Lauria, Giuseppe ^b  

^a SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Infection and Immunology   (Netherlands)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Burning pain; Itch; Neuropathic pain; Paroxysmal; SCN9A; Small nerve fiber; Sodium channels

Indexed keywords

PREGABALIN; SODIUM CHANNEL NAV1.7; 4 AMINOBUTYRIC ACID; ANTIPRURITIC AGENT; SCN9A PROTEIN, HUMAN;

ADULT; ARTICLE; CARDIOVASCULAR REFLEX; CASE REPORT; DNA DETERMINATION; ENVIRONMENTAL FACTOR; EXON; FEMALE; FLUSHING; GAIN OF FUNCTION MUTATION; HEAT SENSATION; HUMAN; HYPESTHESIA; HYPOALGESIA; MIDDLE AGED; MOTOR NERVE CONDUCTION; NERVE FIBER; NEUROLOGIC EXAMINATION; PAIN; PAIN THRESHOLD; PAROXYSMAL ITCH; PERCEPTIVE THRESHOLD; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PRURITUS; SENSORY EVALUATION; SKIN BIOPSY; ANALOGS AND DERIVATIVES; GENETICS; MALE; MUTATION; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; STIMULATION; TREATMENT OUTCOME;

ADULT; ANTIPRURITICS; CHILD, PRESCHOOL; DNA MUTATIONAL ANALYSIS; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MUTATION; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; PAIN; PAIN THRESHOLD; PHYSICAL STIMULATION; PRURITUS; TREATMENT OUTCOME;

EID: 84926409870     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2014.05.006     Document Type: Article

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