Inhibition of phosphoinositol 3 kinase contributes to nanoparticle-mediated exaggeration of endotoxin-induced leukocyte procoagulant activity

Nanomedicine

Volumn 9, Issue 9, 2014, Pages 1311-1326

  Ilinskaya, Anna N ^a   Man, Sonny ^a   Patri, Anil K ^a   Clogston, Jeffrey D ^a   Crist, Rachael M ^a   Cachau, Raul E ^a   Mcneil, Scott E ^a   Dobrovolskaia, Marina A ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

coagulopathy; dendrimer; disseminated intravascular coagulation; leukocyte; nanoparticle; procoagulant activity; thrombosis

Indexed keywords

AMINE; DENDRIMER; ENDOTOXIN; FLUORESCEIN ISOTHIOCYANATE; NANOPARTICLE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLSERINE; POLYPAMIDOAMINE) DENDRIMER; PROCOAGULANT; THROMBOPLASTIN; TOLL LIKE RECEPTOR 4; TRITON X 114; UNCLASSIFIED DRUG; WORTMANNIN; BLOOD CLOTTING FACTOR; CATION; ENZYME INHIBITOR; LEUKOCYTE PROCOAGULANT ACTIVITY; LIPOPOLYSACCHARIDE; POLYAMIDOAMINE; POLYAMINE;

ARTICLE; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; ENDOTOXIN DETECTION; ENDOTOXIN INDUCED LEUKOCYTE PROCOAGULANT ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; STATIC ELECTRICITY; SURFACE PROPERTY; THROMBOCYTE; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DISSEMINATED INTRAVASCULAR COAGULATION; DRUG EFFECTS; LEUKOCYTE; METABOLISM;

BLOOD COAGULATION FACTORS; CATIONS; DENDRIMERS; DISSEMINATED INTRAVASCULAR COAGULATION; ENDOTOXINS; ENZYME INHIBITORS; HUMANS; IN VITRO TECHNIQUES; LEUKOCYTES; LIPOPOLYSACCHARIDES; NANOPARTICLES; PHOSPHATIDYLINOSITOL 3-KINASES; POLYAMINES;

EID: 84907028483     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.13.137     Document Type: Article

References (60)

1. Levi M. Disseminated intravascular coagulation. Crit. Care Med. 35(9), 2191-2195 (2007
2. Levi M, Schultz M, van der Poll T. Disseminated intravascular coagulation in infectious disease. Semin. Thromb. Hemost. 36(4), 367-377 (2010
3. Franchini M, Di Minno MN, Coppola A. Disseminated intravascular coagulation in hematologic malignancies. Semin. Thromb. Hemost. 36(4), 388-403 (2010
4. Lippi G, Cervellin G. Disseminated intravascular coagulation in trauma injuries. Semin. Thromb. Hemost. 36(4), 378-387 (2010
5. Montagnana M, Franchi M, Danese E, Gotsch F, Guidi GC. Disseminated intravascular coagulation in obstetric and gynecologic disorders. Semin. Thromb. Hemost. 36(4), 404-418 (2010
6. Furie B, Furie BC. Mechanisms of thrombus formation. N. Engl. J. Med. 359(9), 938-949 (2008
7. Morrissey JH, Davis-Harrison RL, Tavoosi N et al. Protein- phospholipid interactions in blood clotting. Thromb. Res. 125(Suppl. 1), S23-S25 (2010
8. Osterud B, Bjorklid E. Tissue factor in blood cells and endothelial cells. Front. Biosci. (Elite Ed.) 4, 289-299 (2012
9. Bach RR. Tissue factor encryption. Arterioscler. Thromb. Vasc. Biol. 26(3), 456-461 (2006
10. Shaw AW, Pureza VS, Sligar SG, Morrissey JH. The local phospholipid environment modulates the activation of blood clotting. J. Biol. Chem. 282(9), 6556-6563 (2007
11. Greish K, Thiagarajan G, Herd H et al. Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles. Nanotoxicology 6, 713-723 (2012
12. Nabeshi H, Yoshikawa T, Matsuyama K et al. Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure. Nanotechnology 23(4), 045101 (2012
13. Dobrovolskaia MA, Patri AK, Potter TM, Rodriguez JC, Hall JB, McNeil SE. Dendrimer-induced leukocyte procoagulant activity depends on particle size and surface charge. Nanomedicine (Lond.) 7(2), 245-256 (2012
14. Dobrovolskaia MA, Patri AK, Simak J et al. Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro. Mol. Pharm. 9(3), 382-393 (2012
15. Jones CF, Campbell RA, Brooks AE et al. Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS Nano 6(11), 9900-9910 (2012
16. Jones CF, Campbell RA, Franks Z et al. Cationic PAMAM dendrimers disrupt key platelet functions. Mol. Pharm. 9(6), 1599-1611 (2012
17. Zhang M, Tracey KJ. Endotoxin and cancer. In: Endotoxin in Health and Disease. Brade H (Ed.). Marcel Dekker, NY, USA, 915-926 (1999
18. Engelhardt R, Otto F, Mackensen A, Mertelsmann R, Galanos C. Endotoxin (Salmonella abortus equi) in cancer patients. Clinical and immunological findings. Prog. Clin. Biol. Res. 392, 253-261 (1995
19. Engelhardt R, Mackensen A, Galanos C. Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients. Cancer Res. 51(10), 2524-2530 (1991
20. US Pharmacopeial Convention. Bacterial endotoxin test. In: US Pharmacopeia 30 National Formulary 25. US Pharmacopeial Convention, MD, USA (2007
21. Vallhov H, Qin J, Johansson SM et al The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications. Nano Lett. 6(8), 1682-1686 (2006
22. Dobrovolskaia MA, McNeil SE. Endotoxin and engineered nanomaterials. In: Handbook of Immunological Properties of Engineered Nanomaterials. Yarmush ML, Shi D (Eds). World Scientific Publishing, Singapore, 77-115 (2012
23. Jones CF, Castner DG, Grainger DW. Surface adsorbates on nanomaterial sand. Their possible roles in host inflammatory and toxocological processing. In: Handbook of Immunological Properties of Engineered Nanomaterials. Yarmush ML, Shi D (Eds). World Scientific Publishing, Singapore, 117-143 (2012
24. Inoue K. Promoting effects of nanoparticles/materials on sensitive lung inflammatory diseases. Environ. Health Prev. Med. 16(3), 139-143 (2011
25. Inoue K, Takano H, Koike E et al. Effects of pulmonary exposure to carbon nanotubes on lung and systemic inflammation with coagulatory disturbance induced by lipopolysaccharide in mice. Exp. Biol. Med. (Maywood) 233(12), 1583-1590 (2008
26. Hamilton RF, Wu N, Porter D, Buford M, Wolfarth M, Holian A. Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity. Part. Fibre Toxicol. 6, 35 (2009
27. Shi Y, Yadav S, Wang F, Wang H. Endotoxin promotes adverse effects of amorphous silica nanoparticles on lung epithelial cells in vitro. J. Toxicol. Environ. Health A 73(11), 748-756 (2010
28. Duncan R, Gaspar R. Nanomedicine(s) under the microscope. Mol. Pharm. 8(6), 2101-2141 (2011
29. Bernatowicz MS, Wu YL, Matsueda GR. 1H-pyrazole- 1-carboxamidine hydrochloride - an attractive reagent for guanylation of amines and its application to peptide-synthesis. J. Org. Chem. 57(8), 2497-2502 (1992
30. Tziveleka LA, Psarra AM, Tsiourvas D, Paleos CM. Synthesis and characterization of guanidinylated poly(propylene imine) dendrimers as gene transfection agents. J. Control. Release 117(1), 137-146 (2007
31. Arcaro A, Wymann MP. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296(Pt 2), 297-301 (1993
32. Henriksson CE, Klingenberg O, Hellum M et al. Calcium ionophore-induced de-encryption of tissue factor in monocytes is associated with extensive cell death. Thromb. Res. 119(5), 621-630 (2007
33. Nicolaou G, Goodall AH, Erridge C. Diverse bacteria promote macrophage foam cell formation via Toll-like receptor-dependent lipid body biosynthesis. J. Atheroscler. Thromb. 19(2), 137-148 (2012
34. Chu AJ, Rauci M, Nwobi OI, Mathews ST, Beydoun S. Novel anticoagulant activity of polyamino acid offsets bacterial endotoxin-induced extrinsic hypercoagulation: downregulation of monocytic tissue factor-dependent FVII activation. J. Cardiovasc. Pharmacol. 42(4), 477-483 (2003
35. Lynn WA, Golenbock DT. Lipopolysaccharide antagonists. Immunol. Today 13(7), 271-276 (1992
36. Ziegler-Heitbrock HW, Thiel E, Futterer A, Herzog V, Wirtz A, Riethmuller G. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int. J. Cancer 41(3), 456-461 (1988
37. Drexler HG, Quentmeier H, MacLeod RA. Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations. Leukemia 18(2), 227-232 (2004
38. Gebhard C, Holy EW, Camici GG et al. Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition. Thromb. Haemost. 107(5), 884-894 (2012
39. Dobrovolskaia MA, McNeil SE. In vitro assays for monitoring nanoparticle interaction with components of the immune system. In: Handbook of Immunological Properties of Engineered Nanomaterials. Yarmush ML, Shi D (Eds). World Scientific Publishing, Singapore, 581-634 (2012
40. Jones CF, Grainger DW. In vitro assessments of nanomaterial toxicity. Adv. Drug Deliv. Rev. 61(6), 438-456 (2009
41. Hong S, Bielinska AU, Mecke A et al. Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport. Bioconjug. Chem. 15(4), 774-782 (2004
42. Hong S, Leroueil PR, Janus EK et al. Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability. Bioconjug. Chem. 17(3), 728-734 (2006
43. Mecke A, Majoros IJ, Patri AK, Baker JR Jr, Holl MM, Orr BG. Lipid bilayer disruption by polycationic polymers: the roles of size and chemical functional group. Langmuir 21(23), 10348-10354 (2005
44. Lee H, Larson RG. Molecular dynamics simulations of PAMAM dendrimer-induced pore formation in DPPC bilayers with a coarse-grained model. J. Phys. Chem. B 110(37), 18204-18211 (2006
45. Mukherjee SP, Lyng FM, Garcia A, Davoren M, Byrne HJ. Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells. Toxicol. Appl. Pharmacol. 248(3), 259-268 (2010
46. Stern ST, Adiseshaiah PP, Crist RM. Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part. Fibre Toxicol. 9, 20 (2012
47. Rao LV, Kothari H, Pendurthi UR. Tissue factor: mechanisms of decryption. Front. Biosci. (Elite Ed.) 4, 1513-1527 (2012
48. Vadivel K, Bajaj SP. Structural biology of factor VIIa/tissue factor initiated coagulation. Front. Biosci. (Landmark Ed.) 17, 2476-2494 (2012
49. Egorina EM, Sovershaev MA, Bjorkoy G et al. Intracellular and surface distribution of monocyte tissue factor: application to intersubject variability. Arterioscler. Thromb. Vasc. Biol. 25(7), 1493-1498 (2005
50. Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, Gimbrone MA Jr. Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J. Exp. Med. 160(2), 618-623 (1984
51. Norris LA, Weldon S, Nugent A, Roche HM. LPS induced tissue factor expression in the THP-1 monocyte cell line is attenuated by conjugated linoleic acid. Thromb. Res. 117(4), 475-480 (2006
52. Chu AJ, Wang ZG, Walton MA, Seto A. Involvement of MAPK activation in bacterial endotoxin-inducible tissue factor upregulation in human monocytic THP-1 cells. J. Surg. Res. 101(1), 85-90 (2001
53. Kubota T, Andoh K, Sadakata H, Tanaka H, Kobayashi N. Tissue factor released from leukemic cells. Thromb. Haemost. 65(1), 59-63 (1991
54. Langer F, Amirkhosravi A, Loges S et al. An in vitro study on the mechanisms of coagulation activation in acute myelogenous leukemia (AML): role of tissue factor regulation by cytotoxic drugs and GM-CSF. Thromb. Haemost. 92(5), 1136-1146 (2004
55. Boles JC, Williams JC, Hollingsworth RM et al. Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity. Thromb. Res. 129(2), 197-203 (2012
56. Osterud B. The role of platelets in decrypting monocyte tissue factor. Dis. Mon. 49(1), 7-13 (2003
57. Bach R, Rifkin DB. Expression of tissue factor procoagulant activity: regulation by cytosolic calcium. Proc. Natl Acad. Sci. USA 87(18), 6995-6999 (1990
58. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Invest. 97, 77-89 (1968
59. Guha M, Mackman N. The phosphatidylinositol 3-kinase- Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277(35), 32124-32132 (2002
60. Steffel J, Latini RA, Akhmedov A et al. Rapamycin, but not FK-506, increases endothelial tissue factor expression: implications for drug-eluting stent design. Circulation 112(13), 2002-2011 (2005